Výsledky vyhledávání

Monitoring the real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

Autor: Tarasov, A, Galvanovskis, J, Rorsman, O, Hamilton, A, Vergari, E, Johnson, P, Reimann, F, Ashcroft, F, Rorsman, P

High-content real-time imaging of hormone secretion in tissues or cell populations is a challenging task, which is unlikely to be resolved directly, despite immense translational value. We approach this problem indirectly, using compensatory endocyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::880c697d8ee89dcc6d1dcbf07425eddf
https://europepmc.org/articles/PMC6250124/

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AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and reveal an endosomal pathway that spatially-directs G-protein selectivity

Autor: Gorvin, C, Rogers, A, Hastoy, B, Tarasov, A, Frost, M, Sposini, S, Inoue, A, Whyte, M, Rorsman, O, Hanyaloglu, A, Breitwieser, G, Thakker, R

Publikováno v: Cell Reports. 22(4)

Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8ed6115de5cf32f7c82e46a29a1b3b1c
http://ora.ox.ac.uk/objects/uuid:

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δ- and β-cells are electrically coupled and regulate α-cell activity via somatostatin

Autor: Briant, L, Reinbothe, T, Spiliotis, I, Miranda, C, Rodriguez, B, Rorsman, O

Publikováno v: Journal of Physiology.

Glucagon, the body’s principal hyperglycaemic hormone, is released from the α-cells of the pancreatic islet. The secretion of this hormone is dysregulated in type 2 diabetes mellitus but the mechanisms controlling secretion are not well understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::965249ab4ee05fe22de016f72a38d759
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Functional identification of islet cell types by electrophysiological fingerprinting

Autor: Briant, L, Zhang, Q, Vergari, E, Kellard, J, Rodriguez, B, Ashcroft, F, Rorsman, O

Publikováno v: Journal of the Royal Society Interface. 14(128)

The α-, β- and δ-cells of the pancreatic islet exhibit different electrophysiological features. We used a large dataset of whole-cell patch-clamp recordings from cells in intact mouse islets (N=288 recordings) to investigate whether it is possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9b66832f84349931589200859fb6a4f9
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Akademický článek

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Glucagon and glucose counterregulation: pancreatic α-cell function and dysfunction during hypoglycaemia

Autor: Hamilton, A

The glucagon-secreting α-cell is vital for the maintenance of glucose homeostasis and prevention of hypoglycaemia. Despite its importance many aspects of α-cell physiology are disputed. Thus, in this thesis, I aimed to elucidate several features of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::0bd00bd2d51972e3d20bcd9034d09dea
https://ora.ox.ac.uk/objects/uuid:a2faab53-07b0-45ca-ad20-8ebfdbd54371

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