Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta

Autor: Chandrakanthan, Vashe, Rorimpandey, Prunella, Zanini, Fabio, Chacon, Diego, Olivier, Jake, Joshi, Swapna, Kang, Young Chan, Knezevic, Kathy, Huang, Yizhou, Qiao, Qiao, Oliver, Rema A, Unnikrishnan, Ashwin, Carter, Daniel R, Lee, Brendan, Brownlee, Chris, Power, Carl, Brink, Robert, Mendez-Ferrer, Simon, Enikolopov, Grigori, Walsh, William, Göttgens, Berthold, Taoudi, Samir, Beck, Dominik, Pimanda, John E

Funder: Wellcome Trust
Mouse haematopoietic stem cells (HSCs) first emerge at embryonic day 10.5 (E10.5), on the ventral surface of the dorsal aorta, by endothelial-to-haematopoietic transition. We investigated whether mesenchymal stem cells, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a3df952f2624837cbe8afee4cdd0f5

Mesoderm-derived PDGFRA+cells regulate the emergence of hematopoietic stem cells in the dorsal aorta

Autor: Chandrakanthan, Vashe, Rorimpandey, Prunella, Zanini, Fabio, Chacon, Diego, Olivier, Jake, Joshi, Swapna, Kang, Young Chan, Knezevic, Kathy, Huang, Yizhou, Qiao, Qiao, Oliver, Rema A., Unnikrishnan, Ashwin, Carter, Daniel R., Lee, Brendan, Brownlee, Chris, Power, Carl, Brink, Robert, Mendez-Ferrer, Simon, Enikolopov, Grigori, Walsh, William, Göttgens, Berthold, Taoudi, Samir, Beck, Dominik, Pimanda, John E.

Publikováno v: Nature Cell Biology; August 2022, Vol. 24 Issue: 8 p1211-1225, 15p

Mesoderm-derived PDGFRA ⁺ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta.

Autor: Chandrakanthan V; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. v.chandrakanthan@unsw.edu.au.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia. v.chandrakanthan@unsw.edu.au., Rorimpandey P; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia., Zanini F; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.; Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia.; UNSW Futures Institute for Cellular Genomics, Sydney, Australia., Chacon D; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia., Olivier J; School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW, Australia., Joshi S; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia., Kang YC; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia., Knezevic K; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia., Huang Y; School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.; School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Qiao Q; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Oliver RA; Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW, Australia., Unnikrishnan A; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia., Carter DR; School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.; School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Lee B; Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Brownlee C; Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Power C; Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia., Brink R; Garvan Institute of Medical Research, Sydney, NSW, Australia.; UNSW Sydney, Sydney, NSW, Australia., Mendez-Ferrer S; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK., Enikolopov G; Center for Developmental Genetics and Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA., Walsh W; Surgical & Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW, Australia., Göttgens B; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK., Taoudi S; Epigenetics and development division, Walter and Eliza Hall Institute, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Beck D; Centre for Health Technologies and the School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia., Pimanda JE; Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; Department of Pathology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; Department of Haematology, The Prince of Wales Hospital, Sydney, NSW, Australia. jpimanda@unsw.edu.au.

Publikováno v: Nature cell biology [Nat Cell Biol] 2022 Aug; Vol. 24 (8), pp. 1211-1225. Date of Electronic Publication: 2022 Jul 28.