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Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis.

Autor: Maciej-Hulme ML; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Van Gemst JJ; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Sanderson P; Department of Chemistry, University of Georgia, Athens, GA, United States., Rops ALWMM; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Berden JH; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Smeets B; Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Amster IJ; Department of Chemistry, University of Georgia, Athens, GA, United States., Rabelink TJ; Department of Nephrology, Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Van Der Vlag J; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

Publikováno v: Frontiers in molecular biosciences [Front Mol Biosci] 2023 Jun 01; Vol. 10, pp. 1177560. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).

Differential binding of chemokines CXCL1, CXCL2 and CCL2 to mouse glomerular endothelial cells reveals specificity for distinct heparan sulfate domains.

Autor: van Gemst JJ; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., Kouwenberg M; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., Rops ALWMM; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., van Kuppevelt TH; Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., Berden JH; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., Rabelink TJ; Department of Nephrology and Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Loeven MA; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands., van der Vlag J; Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

Publikováno v: PloS one [PLoS One] 2018 Sep 24; Vol. 13 (9), pp. e0201560. Date of Electronic Publication: 2018 Sep 24 (Print Publication: 2018).

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Autor: Verkaar F; Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands.; Merck Research Laboratories, Molecular Pharmacology & DMPK, Oss, The Netherlands., van Offenbeek J; Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands.; Merck Research Laboratories, Molecular Pharmacology & DMPK, Oss, The Netherlands., van der Lee MMC; Merck Research Laboratories, Molecular Pharmacology & DMPK, Oss, The Netherlands., van Lith LHCJ; Merck Research Laboratories, Molecular Pharmacology & DMPK, Oss, The Netherlands., Watts AO; Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Rops ALWMM; Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands., Aguilar DC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA, USA., Ziarek JJ; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., van der Vlag J; Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands., Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA, USA., Volkman BF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Proudfoot AEI; Merck Serono Geneva Research Centre, Geneva, Switzerland., Vischer HF; Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands., Zaman GJR; Netherlands Translational Research Center B.V. (NTRC), Oss, The Netherlands., Smit MJ; Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, Amsterdam, The Netherlands.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Apr 15; Vol. 192 (8), pp. 3908-3914. Date of Electronic Publication: 2014 Mar 17.