Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation

Autor: Hunt, C. Anthony, Petersen, BK, Ropella, GEP, Hunt, CA

Publikováno v: Hunt, C. Anthony; Petersen, BK; Ropella, GEP; & Hunt, CA. (2016). Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2gb0z030

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::36915e32fbb7619184e18ea311540cc8
http://www.escholarship.org/uc/item/2gb0z030

Agent-based modeling: A systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity

Autor: Hunt, C. Anthony, Hunt, CA, Kennedy, RC, Kim, SHJ, Ropella, GEP

Publikováno v: Hunt, C. Anthony; Hunt, CA; Kennedy, RC; Kim, SHJ; & Ropella, GEP. (2013). Agent-based modeling: A systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/0sm20216

A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9978d8826cd99d9cf41512e0aa87ff9b
http://www.escholarship.org/uc/item/0sm20216

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms.

Autor: Smith AK; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Ropella GEP; Tempus Dictum, Inc., Milwaukie, Oregon, United States of America., McGill MR; Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America., Krishnan P; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Dutta L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Kennedy RC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America., Jaeschke H; Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America., Hunt CA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2020 Jun 02; Vol. 16 (6), pp. e1007622. Date of Electronic Publication: 2020 Jun 02 (Print Publication: 2020).

A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation.

Autor: Smith AK; Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (A.K.S., Y.X., C.A.H.); and Tempus Dictum, Inc., Milwaukie, Oregon (G.E.P.R.)., Xu Y; Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (A.K.S., Y.X., C.A.H.); and Tempus Dictum, Inc., Milwaukie, Oregon (G.E.P.R.)., Ropella GEP; Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (A.K.S., Y.X., C.A.H.); and Tempus Dictum, Inc., Milwaukie, Oregon (G.E.P.R.)., Hunt CA; Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (A.K.S., Y.X., C.A.H.); and Tempus Dictum, Inc., Milwaukie, Oregon (G.E.P.R.) a.hunt@ucsf.edu.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Apr; Vol. 365 (1), pp. 127-138. Date of Electronic Publication: 2018 Feb 06.