Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roosa-Maria Plaketti"'
Autor:
Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti, Aurora Taira, Päivi Sulo, Tuomo Hartonen, Kashyap Dave, Bernhard Schmierer, Sandeep Botla, Maria Sokolova, Anna Vähärautio, Kornelia Gladysz, Halit Ongen, Emmanouil Dermitzakis, Jesper Bertram Bramsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen, Ari Ristimäki, Anna Lepistö, Laura Renkonen-Sinisalo, Jukka-Pekka Mecklin, Jussi Taipale, Lauri A. Aaltonen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network
Externí odkaz:
https://doaj.org/article/0d1e862be9834942b8b1513c12b2e466
Autor:
Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa‐Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen‐Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka‐Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-20 (2018)
Abstract Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite‐
Externí odkaz:
https://doaj.org/article/ef342cd752574cf1b549cf1e60ecdf37
Autor:
Ulrika A Hänninen, Riku Katainen, Tomas Tanskanen, Roosa-Maria Plaketti, Riku Laine, Jiri Hamberg, Ari Ristimäki, Eero Pukkala, Minna Taipale, Jukka-Pekka Mecklin, Linda M Forsström, Esa Pitkänen, Kimmo Palin, Niko Välimäki, Netta Mäkinen, Lauri A Aaltonen
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007200 (2018)
Small bowel adenocarcinoma (SBA) is an aggressive disease with limited treatment options. Despite previous studies, its molecular genetic background has remained somewhat elusive. To comprehensively characterize the mutational landscape of this tumor
Externí odkaz:
https://doaj.org/article/52a0787cbdd2476e9bf29a7804fc6c88
Autor:
Riku Katainen, Roosa-Maria Plaketti, Juho Kariniemi, Outi Kuismin, Pekka Romsi, Linda M. Forsström, Mervi Aavikko, Anna Kuosmanen, Iikki Donner, Lauri A. Aaltonen, Lauri J. Sipilä
Publikováno v:
Vascular. 30:842-847
Background Visceral artery aneurysms (VAAs) can be fatal if ruptured. Although a relatively rare incident, it holds a contemporary mortality rate of approximately 12%. VAAs have multiple possible causes, one of which is genetic predisposition. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbe6fbc8b71cf8bed6dfce5597d78b5
https://doi.org/10.1177/17085381211033157
https://doi.org/10.1177/17085381211033157
Autor:
Emilia Vartiainen, Laura Renkonen-Sinisalo, Kimmo Palin, Selja Koskensalo, Anna Lepistö, Jukka-Pekka Mecklin, Riku Katainen, Roosa Maria Plaketti, Mervi Aavikko, Suvi Lehtipuro, Lauri A. Aaltonen, Päivi Sulo, Janne J. Ravantti, Kirsi J. Granberg, Matti Nykter, Maarit Ahtiainen, Aurora Taira, Kristiina Rajamäki, Toni T. Seppälä, Erkki Ville Wirta, Ari Ristimäki, Jussi Taipale, Anna Kuosmanen, Jan Böhm, Niko Välimäki, Tomas Tanskanen
Publikováno v:
Gastroenterology. 161(2)
doi: 10.1053/j.gastro.2021.04.042 Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3cea3eaf283ee1179c191eadf11849
https://pubmed.ncbi.nlm.nih.gov/33930428
https://pubmed.ncbi.nlm.nih.gov/33930428
Autor:
Jiri Hamberg, Kimmo Palin, Esa Pitkänen, Riku Katainen, Netta Mäkinen, Roosa-Maria Plaketti, Minna Taipale, Riku Laine, Ulrika A. Hänninen, Lauri A. Aaltonen, Linda M. Forsström, Jukka-Pekka Mecklin, Niko Välimäki, Ari Ristimäki, Tomas Tanskanen, Eero Pukkala
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 3, p e1007200 (2018)
PLoS Genetics, Vol 14, Iss 3, p e1007200 (2018)
Small bowel adenocarcinoma (SBA) is an aggressive disease with limited treatment options. Despite previous studies, its molecular genetic background has remained somewhat elusive. To comprehensively characterize the mutational landscape of this tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ac2863de7f9f298a3d54b06c3964bd
http://europepmc.org/articles/PMC5871010
http://europepmc.org/articles/PMC5871010
Autor:
Aurora Taira, Emmanouil T. Dermitzakis, Sandeep Kumar Botla, Jussi Taipale, Päivi Sulo, Ulrika A. Hänninen, Bernhard Schmierer, Roosa-Maria Plaketti, Kashyap Dave, Niko Välimäki, Tatiana Cajuso, Torben F. Ørntoft, Anna Vähärautio, Päivi Pihlajamaa, Mervi Aavikko, Maria Sokolova, Halit Ongen, Sari Tuupanen, Johanna Kondelin, Outi Kilpivaara, Anna Lepistö, Kornelia Gladysz, Jukka-Pekka Mecklin, Esa Pitkänen, Eevi Kaasinen, Heli Rauanheimo, Marta Grau, Lauri A. Aaltonen, Mikko P. Turunen, Ari Ristimäki, Linda van den Berg, Riku Katainen, Tuomo Hartonen, Jesper B. Bramsen, Claus L. Andersen, Teemu Kivioja, Tomas Tanskanen, Kimmo Palin, Biswajyoti Sahu, Laura Renkonen-Sinisalo
Publikováno v:
Palin, K, Pitkänen, E, Turunen, M, Sahu, B, Pihlajamaa, P, Kivioja, T, Kaasinen, E, Välimäki, N, Hänninen, U A, Cajuso, T, Aavikko, M, Tuupanen, S, Kilpivaara, O, van den Berg, L, Kondelin, J, Tanskanen, T, Katainen, R, Grau, M, Rauanheimo, H, Plaketti, R-M, Taira, A, Sulo, P, Hartonen, T, Dave, K, Schmierer, B, Botla, S, Sokolova, M, Vähärautio, A, Gladysz, K, Ongen, H, Dermitzakis, E, Bramsen, J B, Ørntoft, T F, Andersen, C L, Ristimäki, A, Lepistö, A, Renkonen-Sinisalo, L, Mecklin, J-P, Taipale, J & Aaltonen, L A 2018, ' Contribution of allelic imbalance to colorectal cancer ', Nature Communications, vol. 9, 3664 . https://doi.org/10.1038/s41467-018-06132-1
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications, Vol. 9, No 1 (2018) P. 3664
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications, Vol. 9, No 1 (2018) P. 3664
Point mutations in cancer have been extensively studied but chromosomal gains and losses have been more challenging to interpret due to their unspecific nature. Here we examine high-resolution allelic imbalance (AI) landscape in 1699 colorectal cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12af55a05ccaa6e0100715add27700fa
http://urn.fi/URN:NBN:fi:jyu-201809174145
http://urn.fi/URN:NBN:fi:jyu-201809174145
Autor:
Riku Katainen, Lauri A. Aaltonen, Xiaonan Liu, Emmanouil T. Dermitzakis, Outi Kilpivaara, Alexandra E. Gylfe, Eevi Kaasinen, Minna Taipale, Esa Pitkänen, Jussi Taipale, Kristian Ovaska, Sari Tuupanen, Lilli Saarinen, Halit Ongen, Heikki Ristolainen, Pia Vahteristo, Kimmo Palin, Laura Renkonen-Sinisalo, Selja Koskensalo, Ulrika A. Hänninen, Jan Böhm, Anna Lepistö, Jiri Hamberg, Johanna Kondelin, Heli Rauanheimo, Jukka-Pekka Mecklin, Niko Välimäki, Mikko P. Turunen, Tomas Tanskanen, Sampsa Hautaniemi, Kari Salokas, Auli Karhu, Roosa-Maria Plaketti, Leena Yadav, Tatiana Cajuso, Markku Varjosalo, Mervi Aavikko
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp n/a-n/a (2018)
EMBO Molecular Medicine, Vol. 10, No 9 (2018) P. e8552
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol. 10, No 9 (2018) P. e8552
EMBO Molecular Medicine
Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953f75f6fbc45f190b7b1acf46bc547e
http://hdl.handle.net/10138/299729
http://hdl.handle.net/10138/299729