Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Roopesh Anand"'
Autor:
Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.
Externí odkaz:
https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee
Autor:
Ondrej Belan, George Moore, Artur Kaczmarczyk, Matthew D. Newton, Roopesh Anand, Simon J. Boulton, David S. Rueda
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100588- (2021)
Summary: Here, we describe a rapid and versatile protocol to generate gapped DNA substrates for single-molecule (SM) analysis using optical tweezers via site-specific Cas9 nicking and force-induced melting. We provide examples of single-stranded (ss)
Externí odkaz:
https://doaj.org/article/92f6855a06464360bfd83a5d6632be34
Autor:
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf
Autor:
Jun Hyun Kim, Malgorzata Grosbart, Roopesh Anand, Claire Wyman, Petr Cejka, John H.J. Petrini
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 496-507 (2017)
Summary: The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential for viability at the cellular and organismal l
Externí odkaz:
https://doaj.org/article/68d187aa74d04edcb58288f41d7cba70
Autor:
Huiming Lu, Raghavendra A. Shamanna, Guido Keijzers, Roopesh Anand, Lene Juel Rasmussen, Petr Cejka, Deborah L. Croteau, Vilhelm A. Bohr
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 161-173 (2016)
The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end resection, which is the initial and an essential step of homologous recombination (H
Externí odkaz:
https://doaj.org/article/ed1c1ede51e940ae8554082a50f5dfce
Publikováno v:
Current Opinion in Genetics & Development
Homologous recombination (HR) plays a critical role in largely error-free repair of mitotic and meiotic DNA double-strand breaks (DSBs). DSBs are one of the most deleterious DNA lesions, which are repaired by non-homologous end joining (NHEJ), homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d1b2495efbdaca7fa808615c31fa15
https://doi.org/10.1016/j.gde.2021.06.005
https://doi.org/10.1016/j.gde.2021.06.005
Autor:
Matthew D. Newton, Jacob S. Lewis, Roopesh Anand, Elizabeth P. Holmes, Alice L.B. Pyne, Simon J. Boulton
Publikováno v:
Biophysical Journal. 122:9a-10a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9138433abee8c07b0e7e013b13fb8eb
https://doi.org/10.1016/j.bpj.2022.11.282
https://doi.org/10.1016/j.bpj.2022.11.282
Autor:
Hubert Fleury, Myles K. MacEachern, Clara M. Stiefel, Roopesh Anand, Colin Sempeck, Benjamin Nebenfuehr, Benjamin Dodd, Erin Taylor, Djelika Dansoko, Raquel Ortega, Justin W. Leung, Simon J. Boulton, Nausica Arnoult
SummaryMicrohomology-mediated end-joining (MMEJ) is an intrinsically mutagenic pathway of DNA double strand break repair essential for proliferation of homologous recombination (HR) deficient tumors. While targeting MMEJ has emerged as a powerful str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::219a3739917daa93a63393cb53abfa35
https://doi.org/10.1101/2022.07.21.500989
https://doi.org/10.1101/2022.07.21.500989
Autor:
Hubert Fleury, Myles K. MacEachern, Clara M. Stiefel, Roopesh Anand, Colin Sempeck, Benjamin Nebenfuehr, Kelper Maurer-Alcalá, Kerri Ball, Bruce Proctor, Ondrej Belan, Erin Taylor, Raquel Ortega, Benjamin Dodd, Laila Weatherly, Djelika Dansoko, Justin W. Leung, Simon J. Boulton, Nausica Arnoult
Publikováno v:
Molecular Cell. 83:1429-1445.e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce86a6666cdad4c9be69dda214dece69
https://doi.org/10.1016/j.molcel.2023.03.017
https://doi.org/10.1016/j.molcel.2023.03.017
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48 (10)
Nucleic Acids Research, 48 (10)
DNA double-strand breaks are repaired by end-joining or homologous recombination. A key-committing step of recombination is DNA end resection. In resection, phosphorylated CtIP first promotes the endonuclease of MRE11–RAD50–NBS1 (MRN). Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ac4b9cb9239bb07d8373499fb90f9a
http://europepmc.org/articles/PMC7261161
http://europepmc.org/articles/PMC7261161