Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rony Nehme"'
Surface-based biophysical methods for measuring binding kinetics of molecular interactions, such as Surface Plasmon Resonance (SPR) or Grating-Coupled Interferometry (GCI), are now well established and widely used in drug discovery. Increasing throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caca8df375f7d0f6eed1a46b9112bdd0
https://doi.org/10.1101/2021.02.05.429874
https://doi.org/10.1101/2021.02.05.429874
Autor:
Rony Nehmé, Byron Carpenter, Ankita Singhal, Annette Strege, Patricia C Edwards, Courtney F White, Haijuan Du, Reinhard Grisshammer, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175642 (2017)
Mini-G proteins are the engineered GTPase domains of Gα subunits. They couple to GPCRs and recapitulate the increase in agonist affinity observed upon coupling of a native heterotrimeric G protein. Given the small size and stability of mini-G protei
Externí odkaz:
https://doaj.org/article/a5fac57f40484242b84cb93eef39e9ee
Autor:
Jennifer L Miller-Gallacher, Rony Nehmé, Tony Warne, Patricia C Edwards, Gebhard F X Schertler, Andrew G W Leslie, Christopher G Tate
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92727 (2014)
The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined the structure of an ultra-thermostable β1AR mutant bound to the weak partial agonist cy
Externí odkaz:
https://doaj.org/article/50b41481c95544ee93db8f60e8bb5d68
Autor:
Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat, Isabelle Mus-Veteau
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23834 (2011)
Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tum
Externí odkaz:
https://doaj.org/article/3dc8d928a6f24eb9bb6965f3f54ad58d