Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Rony, Nuydens"'
Autor:
Jan R. Detrez, Hervé Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat, Bart Roucourt, Fred Van Leuven, Sarah Baatout, Peter Larsen, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 398-409 (2019)
We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the three-dimensional spreading pattern of hyperphosphorylated tau in the brain of an aging Tau.P301L
Externí odkaz:
https://doaj.org/article/119ac8d690064ea99cc5b5a136436f56
Autor:
Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Therapeutic developments for neurodegenerative disorders are redirecting their focus to the mechanisms that contribute to neuronal connectivity and the loss thereof. Using a high-throughput microscopy pipeline that integrates morphological a
Externí odkaz:
https://doaj.org/article/3252747729954b5db9d630506798f41d
Autor:
Jan R. Detrez, Inès R.H. Ben-Nejma, Kristof Van Kolen, Debby Van Dam, Peter Paul De Deyn, Erik Fransen, Marleen Verhoye, Jean-Pierre Timmermans, Rony Nuydens, Annemie Van der Linden, Georgios A. Keliris, Winnok H. De Vos
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 105011- (2020)
Progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including Alzheimer's disease. However, to date, the functional effects of tau pathology on brain network connectivity remain poorly understood.
Externí odkaz:
https://doaj.org/article/54d1381527f14dc9bf057304685b4ec7
Autor:
Peter Verstraelen, Gerardo Garcia-Diaz Barriga, Marlies Verschuuren, Bob Asselbergh, Rony Nuydens, Peter H. Larsen, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101542- (2020)
Summary: Most neurological disorders display impaired synaptic connectivity. Hence, modulation of synapse formation may have therapeutic relevance. However, the high density and small size of synapses complicate their quantification. To improve synap
Externí odkaz:
https://doaj.org/article/594e61b4f8c74d69baf9ff38d56cc205
Autor:
Peter Verstraelen, Michiel Van Dyck, Marlies Verschuuren, Nachiket D. Kashikar, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic connectivity. In dementia, synapse dysfunction precedes neu
Externí odkaz:
https://doaj.org/article/41e91a41f5c24492985beb2d16e0b9c1
Autor:
Peter Verstraelen, Jan R. Detrez, Marlies Verschuuren, Jacobine Kuijlaars, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on
Externí odkaz:
https://doaj.org/article/585479908afb4390bea4001ce61e977f
Publikováno v:
Journal of Pain Research, Vol 2009, Iss default, Pp 59-66 (2009)
Sandra Leo1,2, Rony Nuydens1, Theo F Meert11Pain and Neurology, CNS Department, Johnson and Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica N.V, Beerse, Belgium; 2Laboratory of Biological Psychology, University of
Externí odkaz:
https://doaj.org/article/7133d1a4923b4a19b765606c121d4c3e
Autor:
Nathalie Van Acker, Michael Ragé, Hilde Vermeirsch, Dorien Schrijvers, Rony Nuydens, Geert Byttebier, Maarten Timmers, Stefanie De Schepper, Johannes Streffer, Luc Andries, Léon Plaghki, Patrick Cras, Theo Meert
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161441 (2016)
The in vivo cutaneous nerve regeneration model using capsaicin is applied extensively to study the regenerative mechanisms and therapeutic efficacy of disease modifying molecules for small fiber neuropathy (SFN). Since mismatches between functional a
Externí odkaz:
https://doaj.org/article/9b9286a1bea5424e90b5ec9cadb63903
Autor:
Samir Kumar-Singh, Ann Julliams, Rony Nuydens, Chantal Ceuterick, Christine Labeur, Sally Serneels, Krist'l Vennekens, Peter Van Osta, Hugo Geerts, Bart De Strooper, Christine Van Broeckhoven
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 330-340 (2002)
Mutations in the β-amyloid (Aβ) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes. While patients with the Dutch APP mutation (E693Q) have predominantly hemorrhagic strokes, Flemish APP (A692G) patients d
Externí odkaz:
https://doaj.org/article/9dad1697dacf48c3833b0f7b8bcacb3a
Autor:
Steven Biesmans, Theo F. Meert, Jan A. Bouwknecht, Paul D. Acton, Nima Davoodi, Patrick De Haes, Jacobine Kuijlaars, Xavier Langlois, Liam J. R. Matthews, Luc Ver Donck, Niels Hellings, Rony Nuydens
Publikováno v:
Mediators of Inflammation, Vol 2013 (2013)
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In t
Externí odkaz:
https://doaj.org/article/311938837c58467bba910192a119c888