Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Autor: Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, Jacco van Rheenen

Publikováno v: Cell Reports, Vol 14, Iss 10, Pp 2281-2288 (2016)

Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations artificially

Externí odkaz: https://doaj.org/article/2e0a3ea64e264b71986d59629f1e2f8d

Cellular drivers of injury response and regeneration in the adult zebrafish heart

Autor: Ronny Schäfer, Jan Philipp Junker, B. Hu, Mariana G. Simões, Daniela Panáková, S. Lelek, Fabian J. Theis, Bastiaan Spanjaard, Hananeh Aliee

Myocardial infarction is a leading cause of death worldwide, as the adult human heart does not have the ability to regenerate efficiently after insults. In contrast, the adult zebrafish heart has a high capacity for regeneration, and understanding th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dd5457afef8181857dab3cbc798e084
https://doi.org/10.1101/2021.01.07.425670

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Autor: Carrie Maynard, Emile E. Voest, Evelyne Beerling, Alexander van Oudenaarden, Jacco van Rheenen, Daphne L. van der Velden, Paul J. van Diest, Lennart Kester, Ronny Schäfer, Elzo de Wit, Nienke Vrisekoop, Danielle Seinstra

Publikováno v: Cell Reports [E], 14(10), 2281. Cell Press
Cell Reports
Cell Reports, Vol 14, Iss 10, Pp 2281-2288 (2016)
Cell Reports, 14(10), 2281-8. Cell Press

Summary Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations arti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b383fa9db1e00f3c63f26c621bcd5f9e
https://dspace.library.uu.nl/handle/1874/336874

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis

Autor: Nienke Vrisekoop, Danielle Seinstra, Laila Ritsma, Ton N. Schumacher, Jacco van Rheenen, Cindy J.M. Loomans, Ronny Schäfer, Anoek Zomer, Eelco J.P. de Koning, Léon van Gurp, Anko M. de Graaff, Danielle A.E. Raats, Onno Kranenburg, Inne H.M. Borel Rinkes, Evelyne Beerling, Carmen Gerlach, Ernst J.A. Steller

Publikováno v: Science Translational Medicine, 4(158). American Association for the Advancement of Science (AAAS)
Science Translational Medicine, 4(158)

Cell dynamics in subcutaneous and breast tumors can be studied through conventional imaging windows with intravital microscopy. By contrast, visualization of the formation of metastasis has been hampered by the lack of long-term imaging windows for m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35237b666d9ab7043c312b4d9c4c1109
https://pure.knaw.nl/portal/en/publications/5dae2d30-5823-4db8-ba69-3e12d407bb19

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

Autor: Dieter Wicher, Marcus C. Stensmyr, Ronny Schäfer, Regine Heller, Stefan H. Heinemann, René Bauernfeind, Bill S. Hansson

Publikováno v: Nature. 452(7190)

From worm to man, many odorant signals are perceived by the binding of volatile ligands to odorant receptors that belong to the G-protein-coupled receptor (GPCR) family. They couple to heterotrimeric G-proteins, most of which induce cAMP production.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5ddb8dc3c1bca335b3731760f943d8
https://pubmed.ncbi.nlm.nih.gov/18432233