Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ronnie L. Yeager"'
Autor:
Prathap Kumar S. Mahalingaiah, Rita Ciurlionis, Bhupinder Bawa, Michael J. Liguori, Terry R. Van Vleet, Binu K. Philip, Kenneth R. Durbin, Ronnie L. Yeager, Srinivasa R. Mantena, Brian P. Enright
Publikováno v:
Pharmacology & Therapeutics. 200:110-125
Antibody-drug conjugates (ADCs) are a promising therapeutic modality for oncology indications. The concept of an ADC platform is to increase the therapeutic index (TI) of chemotherapeutics through more selective delivery of cytotoxic agents to tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275e67fbf57becdf447bb218d67a52af
https://doi.org/10.1016/j.pharmthera.2019.04.008
https://doi.org/10.1016/j.pharmthera.2019.04.008
Publikováno v:
Regulatory Toxicology and Pharmacology. 60:40-45
Cynomolgus monkeys are an important and widely used species in preclinical toxicology studies. During the in-life phase of study, body weight effects may be indicative of toxicity; however, trends in body weight and body weight variability are often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364a8bf640ec0883556f402e83514d59
https://doi.org/10.1016/j.yrtph.2011.02.001
https://doi.org/10.1016/j.yrtph.2011.02.001
Publikováno v:
Toxicology and Applied Pharmacology. 245:326-334
Oxidative stress has been proposed as an important promoter of the progression of fatty liver diseases. The current study investigates the potential functions of the Nrf2-Keap1 signaling pathway, an important hepatic oxidative stress sensor, in a rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39839761ce431ffb86090df5280677a8
https://doi.org/10.1016/j.taap.2010.03.016
https://doi.org/10.1016/j.taap.2010.03.016
Publikováno v:
Toxicological Sciences. 111:238-246
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces genes via the transcription factor aryl hydrocarbon receptor (AhR), including Cyp1a1, NAD(P)H:quinone oxidoreductase 1 (Nqo1), UDP-glucuronosyltransferase 1a6 (Ugt1a6), and glutathione S-transferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d888c8d2a4af48449c67ca06c714f63b
https://doi.org/10.1093/toxsci/kfp115
https://doi.org/10.1093/toxsci/kfp115
Publikováno v:
Toxicological Sciences. 109:24-30
Sulfobromophthalein (BSP) is used to study hepatobiliary excretory function. BSP is conjugated with glutathione (GSH), whereas its dibrominated analog disulfobromophthalein (DBSP) is not conjugated with GSH prior to biliary excretion. In addition, bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cdaa6d24e70b507d5b8c2b9ef39746
https://doi.org/10.1093/toxsci/kfp045
https://doi.org/10.1093/toxsci/kfp045
Publikováno v:
BioScience. 57:673-679
In scientific investigations, performing initial exploratory studies can help in generating hypotheses and deciding what to study in more detail later. Little-known modern graphical methods can be powerful tools for exploration of complex data. We il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5053f9ce769ff52621effe5d0cd6713
https://doi.org/10.1641/b570807
https://doi.org/10.1641/b570807
Autor:
Ronnie L. Yeager, Ruth A. Sanders, Deanna A. Oleske, Janis T. Eells, John B. Watkins, Diane S. Henshel
Publikováno v:
Medical Hypotheses. 69:372-376
Melatonin is well recognized for its role as a potent antioxidant and is directly implicated in the free radical theory of aging [1] [Reiter RJ, Pablos MI, Agapito TT, Guerrero JM. Melatonin in the context of the free radical theory of aging. Ann N Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8204edf6800bdcf5e80ecf3f6cea9ebe
https://doi.org/10.1016/j.mehy.2006.12.041
https://doi.org/10.1016/j.mehy.2006.12.041
Autor:
David A. Paz, Rina Das, Ronnie L. Yeager, Mary P. Connelly, Lisa J. Gould, Margaret T.T. Wong-Riley, Huan Ling Liang, Kristina D Desmet, Deborah S. Millsap, Jinhwan Lim, Janis T. Eells, Harry T. Whelan, Brian D. Hodgson, Jesse J Corry, Marti Jett, Ellen Buchmann, Michele M. Henry, Diane S. Henshel, Julia V Dovi, David A. Margolis
Publikováno v:
Photomedicine and Laser Surgery. 24:121-128
This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various in vitro and in vivo models. Low-intensity light therapy, commonly referred to as "photobiomodulation," uses light in the far-red to near-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313a2c74f8b01b5b5dc8b59772b5803b
https://doi.org/10.1089/pho.2006.24.121
https://doi.org/10.1089/pho.2006.24.121
Autor:
Ashley V. Jasevicius, Diane S. Henshel, Deborah S. Millsap, Harry T. Whelan, Janis T. Eells, John B. Watkins, Jinhwan Lim, Ronnie L. Yeager, Ruth A. Sanders
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 20:271-278
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an acutely toxic anthropogenic chemical. Treatment with a red to near-infrared (630-1000 nm) light-emitting diode (LED) attenuates the toxicant-induced oxidative stress and energy deficit in neuronal cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c0c431d9e2803f3dde9cc1318cd94f
https://doi.org/10.1002/jbt.20146
https://doi.org/10.1002/jbt.20146
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 130(2)
During pregnancy, proper hepatobiliary transport and bile acid synthesis protect the liver from cholestatic injury and regulate the maternal and fetal exposure to bile acids, drugs, and environmental chemicals. The objective of this study was to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3c6306f2884c3b8c7587893404276f
https://pubmed.ncbi.nlm.nih.gov/22903823
https://pubmed.ncbi.nlm.nih.gov/22903823