Multi-Drug Therapy Schedules for SARS-COV-2: Smart Repurposing of Old Drugs

Autor: Godefridus J. Peters, Azhar Ansari, Ronney A. De Abreu, Chris J. J. Mulder, Ahmed B. Bayoumy

Publikováno v: Journal of Exploratory Research in Pharmacology. :1-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef3cdd7a223b1bb0ad3edf1281bbb9a
https://doi.org/10.14218/jerp.2020.00022

Pharmacogenetic and clinical aspects of dihydropyrimidine dehydrogenase deficiency

Autor: André B.P. van Kuilenburg, Albert H. van Gennip, Ronney A. De Abreu

Publikováno v: Annals of clinical biochemistry. 40(Part 1):41-45

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU). A deficiency of DPD is increasingly being recognized as the cause of an important pharmacogenetic syndrome. The importance of DPD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd462669c7c45242cc44339ad924582
https://doi.org/10.1258/000456303321016150

Assessment of Mercaptopurine (6Mp) Metabolites and 6Mp Metabolic Key-Enzymes in Childhood Acute Lymphoblastic Leukemia

Autor: C. Brouwer, Valerie de Haas, Jos P.M. Bökkerink, Gertjan L. Kaspers, Ronney A. De Abreu, Anna Wojtuszkiewicz, Ana Barcelos, Jacqueline Cloos, Boas Dubbelman, G.J. Peters, Gerrit Jansen, Hester A. de Groot-Kruseman

Publikováno v: Wojtuszkiewicz, A M, Barcelos, A, Dubbelman, B, Abreu, R, Brouwer, C, Bokkerink, JP, de Haas, V, de Groot-Kruseman, H, Jansen, G, Kaspers, G J L, Cloos, J & Peters, G J 2014, ' Assessment of Mercaptopurine (6Mp) Metabolites and 6Mp Metabolic Key-Enzymes in Childhood Acute Lymphoblastic Leukemia ', Nucleosides, Nucleotides and Nucleic Acids, vol. 33, no. 4-6, pp. 422-433 . https://doi.org/10.1080/15257770.2014.904519
Nucleosides, Nucleotides and Nucleic Acids, 33, 4-6, pp. 422-33
Nucleosides, Nucleotides and Nucleic Acids, 33(4-6), 422-433. Taylor and Francis Ltd.
Nucleosides, Nucleotides and Nucleic Acids, 33, 422-33

Item does not contain fulltext Pediatric acute lymphoblastic leukemia (ALL) is treated with combination chemotherapy including mercaptopurine (6MP) as an important component. Upon its uptake, 6MP undergoes a complex metabolism involving many enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a634983a5d45686c81982871af117977
https://research.vumc.nl/en/publications/e61593f5-8d5a-4302-ba92-a095986a4fa1

Reduced thiopurine methyltransferase activity and development of side effects of azathioprine treatment in patients with rheumatoid arthritis

Autor: Wim Hissink Muller, Boerbooms Am, Ronney A. De Abreu, Henk J. Van Beusekom, J. Stolk, Leo B A van de Putte, Diana G. M. de Koning

Publikováno v: Arthritis & Rheumatism. 41:1858-1866

Objective To investigate thiopurine enzyme activities for their possible value in predicting the development of azathioprine (AZA)-related toxicity in patients with rheumatoid arthritis (RA). Methods Patients with longstanding RA (n = 33) were enroll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::893d85452135ffdf03a98004b0617579
https://doi.org/10.1002/1529-0131(199810)41:10<1858::aid-art19>3.0.co

Kinetics of adenylate metabolism in human and rat myocardium

Autor: Ronney A. De Abreu, Andrzej C. Skladanowski, Jan Willem De Jong, Monique Tavenier

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1244:351-356

Pathways producing and converting adenosine have hardly been investigated in human heart, contrasting work in other species. We compared the kinetics of enzymes associated with purine degradation and salvage in human and rat heart cytoplasm assaying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc4660e7585c89b0321482305db45ec
https://doi.org/10.1016/0304-4165(95)98595-c