Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ronnell Cabuslay"'
Autor:
Ellen Sanford, Roopa Rai, Steven M. Torkelson, William D. Shrader, Ronnell Cabuslay, Bradley A. Katz, Paul A. Sprengeler, Tony Ton, Aleksandr Kolesnikov, Robin Stephens, Wendy B. Young, Christine Yu, John Hendrix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2270-2273
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c66e188d0e81cf4dc4e2d539122d536
https://doi.org/10.1016/j.bmcl.2006.01.017
https://doi.org/10.1016/j.bmcl.2006.01.017
Autor:
Erik Gjerstadt, Ellen Sanford, William D. Shrader, Ellen M. Leahy, Paul A. Sprengeler, Steve Torkelson, Roopa Rai, Juthamas Sukbuntherng, Huiyong Hu, Dange Vijaykumar, Ronnell Cabuslay, Colin O’Bryan, Jennifer R. Riggs, Liang Liu, Wendy B. Young, Tony Ton, Michael B. Shaghafi
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(14)
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0763c6af115b95efd98bed0abab2d60
https://pubmed.ncbi.nlm.nih.gov/16650987
https://pubmed.ncbi.nlm.nih.gov/16650987