Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ronit Shaltiel-Karyo"'
Autor:
Ronit Shaltiel-Karyo, Dan Davidi, Yotam Menuchin, Moran Frenkel-Pinter, Mira Marcus-Kalish, John Ringo, Ehud Gazit, Daniel Segal
Publikováno v:
Parkinson's Disease, Vol 2012 (2012)
Parkinson's disease is a common neurodegenerative disorder with the pathology of α-synuclein aggregation in Lewy bodies. Currently, there is no available therapy that arrests the progression of the disease. Therefore, the need of animal models to fo
Externí odkaz:
https://doaj.org/article/711965cae23a4f99a426882e84fba970
Autor:
Ronit Shaltiel-Karyo, Moran Frenkel-Pinter, Nirit Egoz-Matia, Anat Frydman-Marom, Deborah E Shalev, Daniel Segal, Ehud Gazit
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13863 (2010)
The intracellular oligomerization of α-synuclein is associated with Parkinson's disease and appears to be an important target for disease-modifying treatment. Yet, to date, there is no specific inhibitor for this aggregation process. Using unbiased
Externí odkaz:
https://doaj.org/article/0e29108f092d46c9800d83e5b2919dc0
Autor:
Yuval Ramot, Yonit Tsarfati, Rosa Anna Manno, Abraham Nyska, Oron Yacoby-Zeevi, Ronit Shaltiel-Karyo, Robert R. Maronpot, Giuseppe Sacco
Publikováno v:
Toxicologic Pathology. 45:764-773
A 90-day study in Göttingen minipigs was conducted to test the local tolerability and systemic toxicity of ND0612, a novel aqueous solution of carbidopa (CD)/levodopa (LD) intended for the treatment of Parkinson’s disease by continuous subcutaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc853824113b57247c89df4d406d23a
https://doi.org/10.1177/0192623317729891
https://doi.org/10.1177/0192623317729891
Autor:
Ronit Shaltiel-Karyo, Sheila Oren, Irena Weinstock, Oron Yacoby-Zeevi, Eduardo Zawaznik, Yoseph Caraco, Peter A. LeWitt, Mara Nemas
Publikováno v:
Clinical neuropharmacology. 42(4)
OBJECTIVES Although commercially available levodopa (LD) formulations include carbidopa (CD) or benserazide for gastrointestinal L-aromatic amino acid decarboxylase inhibition, little is known how manipulating CD delivery affects the pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee58e5c359e2c0cac12a0c550a02efa
https://pubmed.ncbi.nlm.nih.gov/31192808
https://pubmed.ncbi.nlm.nih.gov/31192808
Autor:
Anat Ezer, Ayala Lampel, Daniel L. Segal, Ehud Gazit, Ronit Shaltiel-Karyo, Yaron Bram, Roni Scherzer-Attali
Publikováno v:
Angewandte Chemie. 127:2090-2095
Amyloid deposits are pathological hallmark of a large group of human degenerative disorders of unrelated etiologies. While accumulating evidence suggests that early oligomers may account for tissue degeneration, most detection tools do not allow the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e66d9316457aa89dac5ad439a7cf52e
https://doi.org/10.1002/ange.201408744
https://doi.org/10.1002/ange.201408744
Autor:
Abraham Nyska, Irena Weinstock, Mara Nemas, Oron Yacoby-Zeevi, Ronit Shaltiel-Karyo, Eduardo Zawoznik, Yael S. Schiffenbauer, Anna Rubinski, Yuval Ramot, Yonit Tsarfati
Publikováno v:
Toxicologic pathology. 45(4)
Infusion site reactions are common following subcutaneous infusion of drugs. Such reactions can lead to discontinuation of the treatment. Therefore, assessment of such reactions is essential during preclinical safety studies, and magnetic resonance i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4349368dc894c0e4a2ce7fbcaf135be7
https://pubmed.ncbi.nlm.nih.gov/28443458
https://pubmed.ncbi.nlm.nih.gov/28443458
Autor:
Moran Frenkel-Pinter, Christina Patrick, Edward Rockenstein, Nirit Egoz-Matia, Daniel L. Segal, Eliezer Masliah, Ehud Gazit, Ronit Shaltiel-Karyo, Michal Levy-Sakin, Abigail Schiller
Publikováno v:
Journal of Biological Chemistry. 288:17579-17588
The development of disease-modifying therapy for Parkinson disease has been a main drug development challenge, including the need to deliver the therapeutic agents to the brain. Here, we examined the ability of mannitol to interfere with the aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67c1d8b84f44ecbfc461d1dadc1c9ed
https://doi.org/10.1074/jbc.m112.434787
https://doi.org/10.1074/jbc.m112.434787
Autor:
Daniel L. Segal, Ehud Gazit, Ronit Shaltiel-Karyo, Dan Davidi, Michael Ovadia, Moran Frenkel-Pinter
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1820:1628-1635
Background The oligomeriztion of α-synuclein (α-syn) into ordered assemblies is associated with the symptoms of Parkinson's Disease (PD). Yet, it is still debatable whether oligomers are formed as part of a multistep process towards amyloid fibril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27a7e86c0d16527f52630b521e8b06d
https://doi.org/10.1016/j.bbagen.2012.04.021
https://doi.org/10.1016/j.bbagen.2012.04.021
Autor:
Dorit Trudler, Tali Benromano, Itzik Cooper, Daniel L. Segal, Dorit Farfara, Ronit Shaltiel-Karyo, Niva Segev-Amzaleg, Deborah E. Shalev, M. Vientrov, Aviad Levin, Ehud Gazit, Dan Frenkel, Roni Scherzer-Attali
Publikováno v:
Neurobiology of Disease, Vol 46, Iss 3, Pp 663-672 (2012)
An increasing body of evidence indicates a role for oligomers of the amyloid-β peptide (Aβ) in the neurotoxicity of this peptide and the pathology of Alzheimer's disease (AD). Several neurotoxic oligomeric forms of Aβ have been noted ranging from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16bdc4f86206f7cae8b1a59ef4af7c8
https://doi.org/10.1016/j.nbd.2012.03.005
https://doi.org/10.1016/j.nbd.2012.03.005
Autor:
Daniel Segal, Mira Marcus-Kalish, Ronit Shaltiel-Karyo, Moran Frenkel-Pinter, Yotam Menuchin, Dan Davidi, Ehud Gazit, John Ringo
Publikováno v:
Parkinson's Disease, Vol 2012 (2012)
Parkinson's Disease
Parkinson's Disease
Parkinson's disease is a common neurodegenerative disorder with the pathology ofα-synuclein aggregation in Lewy bodies. Currently, there is no available therapy that arrests the progression of the disease. Therefore, the need of animal models to fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9b526554b0a41a8438f77b2cd3d797
https://doi.org/10.1155/2012/697564
https://doi.org/10.1155/2012/697564