Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ronit Rafaeloff"'
Autor:
Ronit Rafaeloff-Phail, Laura J. Conner, Kimberlee J. Emerson, Don B. McClure, Wu-Kuang Yeh, Harold B. Brooks, Haihong Guo, Liyun Ding
Publikováno v:
Journal of Biological Chemistry. 279:52934-52939
AMP-activated protein kinase (AMPK) serves as an energy-sensing protein kinase that is activated by a variety of metabolic stresses that lower cellular energy levels. When activated, AMPK modulates a network of metabolic pathways that result in net i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da641f3127dddbc9b6329e2f337b157
https://doi.org/10.1074/jbc.m409574200
https://doi.org/10.1074/jbc.m409574200
Autor:
Robert Alan Gadski, Lisa Selsam Beavers, Ronit Rafaeloff-Phail, Helena Corominola, Laura J. Conner, Jose F. Caro, Dwayne Johnson
Publikováno v:
Diabetes. 50:2822-2830
Obesity is associated with an increased risk for developing type 2 diabetes, insulin resistance, hypertension, dyslipidemia, cardiovascular disease, respiratory dysfunction, and certain forms of cancer. Insulin resistance in many type 2 diabetic pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e910e1a751e59e2d5f90e09f8a6d02e8
https://doi.org/10.2337/diabetes.50.12.2822
https://doi.org/10.2337/diabetes.50.12.2822
Autor:
Craig D. Hammond, Michael A. Statnick, Jose F. Caro, Eric Ravussin, Thomas W. Seng, Robert Alan Gadski, Lisa Selsam Beavers, Todd M. Suter, Helena Corominola, Ronit Rafaeloff-Phail, James P. Sluka, Dwayne Johnson, Laura J. Conner
Publikováno v:
International journal of experimental diabetes research
We have screened a subtracted cDNA library in order to identify differentially expressed genes in omental adipose tissue of human patients with Type 2 diabetes. One clone (#1738) showed a marked reduction in omental adipose tissue from patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a66d52e6af8f8b220e10b88c1a95f7c
https://doi.org/10.1155/edr.2000.81
https://doi.org/10.1155/edr.2000.81
Autor:
G L Pittenger, Ronit Rafaeloff, W P Duguid, B Yan, Lawrence Rosenberg, Scott W. Barlow, Vinik Ai, X F Qin
Publikováno v:
Journal of Clinical Investigation. 99:2100-2109
Induction of islet neogenesis by cellophane wrapping (CW) reverses streptozotocin-induced (STZ) diabetes. Administration of Ilotropin, a protein extract isolated from CW pancreata, causes recapitulation of normal islet ontogeny and reverses STZ diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5432a66842e2894eda59d526d3a44107
https://doi.org/10.1172/jci119383
https://doi.org/10.1172/jci119383
Publikováno v:
Diabetologia. 39:256-262
Partial pancreatic duct obstruction in the hamster leads to the induction of endocrine-cell differentiation and new islet formation. We prepared cytosolic extracts from the partially obstructed pancreas and identified one, which when administered i.p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a82f29316c2bafac1ee44ffeb308e9
https://doi.org/10.1007/bf00418339
https://doi.org/10.1007/bf00418339
Publikováno v:
The Yale Journal of Biology and Medicine
We have established a model in which cellophane wrapping induces reiteration of the normal ontogeny of beta-cell differentiation from ductal tissue. The secretion of insulin is physiologic and coordinated to the needs of the animal. Streptozotocin-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459386847e962127846727f42cb54f50
https://doi.org/10.1159/000217834
https://doi.org/10.1159/000217834
Publikováno v:
Biochemical and Biophysical Research Communications. 188:318-322
We studied the binding of mutant insulins to both the normal human insulin receptor and an insulin receptor in which the sequence 240–250 of the receptor a subunit was mutated to provide an additional net positive charge. One mutant insulin (AspB 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8493292ea0de2a52bdb70f24ba5de6
https://doi.org/10.1016/0006-291x(92)92387-d
https://doi.org/10.1016/0006-291x(92)92387-d
Autor:
K Y Wong, Vincenzo Trischitta, Ira D. Goldfine, D M Hawley, Ronit Rafaeloff, Paolo Sbraccia, Antonio Brunetti
Publikováno v:
Scopus-Elsevier
We examined the effect of insulin treatment on HTC cells transfected with large numbers of either normal insulin receptors (HTC-IR) or insulin receptors defective in tyrosine kinase (HTC-IR/M-1030). In both HTC-IR and HTC-IR/M-1030 cells, 20 h of ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4b6dc3829f10fe7b266ae4be89de52
https://doi.org/10.1016/s0021-9258(19)34059-1
https://doi.org/10.1016/s0021-9258(19)34059-1
Autor:
William P. Duguid, Ronit Rafaeloff, David Clas, Gary L. Pittenger, Vinik Ai, Yoichiro Kakugawa, Lawrence Rosenberg
Publikováno v:
Pancreas. 13(1)
Partial obstruction of the adult hamster pancreas leads to islet cell differentiation and new islet formation. From morphologic and morphometric observations, we have tentatively identified the source of the new islet tissue to be from cells in the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72492feab3701c054f63593ba5207f0b
https://pubmed.ncbi.nlm.nih.gov/8783332
https://pubmed.ncbi.nlm.nih.gov/8783332
Publikováno v:
Diabetologia. 38(8)
We have reported previously that cellophane wrapping of the hamster pancreas is a stimulus that leads to the induction of duct epithelial cell proliferation, followed by endocrine cell differentiation and new islet formation. Reg is a candidate gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda4bb663fa2234f34591c95be107494
https://pubmed.ncbi.nlm.nih.gov/7589875
https://pubmed.ncbi.nlm.nih.gov/7589875