Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ronit Nir"'
Autor:
Marlon S. Zambrano-Mila, Monika Witzenberger, Zohar Rosenwasser, Anna Uzonyi, Ronit Nir, Shay Ben-Aroya, Erez Y. Levanon, Schraga Schwartz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Millions of adenosines are deaminated throughout the transcriptome by ADAR1 and/or ADAR2 at varying levels, raising the question of what are the determinants guiding substrate specificity and how these differ between the two enzymes. We moni
Externí odkaz:
https://doaj.org/article/4c2d499ad67e4af4a9e51a00babc91cd
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101103- (2022)
Summary: Oligo library pools are powerful tools for systematic investigation of genetic and transcriptomic machinery such as promoter function and gene regulation, non-coding RNAs, or RNA modifications. Here, we provide a detailed protocol for clonin
Externí odkaz:
https://doaj.org/article/de0a67394fa84b1ea2758cdd5bd92fc3
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
MiRNAs are known regulators of gene expression. Here the authors perform a large-scale massively parallel reporter assay to investigate the effect of a large number of designed 3′ UTR sequences on reporter expression and asses how miRNA regulatory
Externí odkaz:
https://doaj.org/article/fb7c84a2a18049cab8a44b70a61543f4
Autor:
Alexey A Gritsenko, Shira Weingarten-Gabbay, Shani Elias-Kirma, Ronit Nir, Dick de Ridder, Eran Segal
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 9, p e1005734 (2017)
Translation of mRNAs through Internal Ribosome Entry Sites (IRESs) has emerged as a prominent mechanism of cellular and viral initiation. It supports cap-independent translation of select cellular genes under normal conditions, and in conditions when
Externí odkaz:
https://doaj.org/article/aef8145668354acebc52a826d8e5e7cd
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002632 (2012)
Drosophila melanogaster Held Out Wings (HOW) is a conserved RNA-binding protein (RBP) belonging to the STAR family, whose closest mammalian ortholog Quaking (QKI) has been implicated in embryonic development and nervous system myelination. The HOW RB
Externí odkaz:
https://doaj.org/article/c665d74f7ee14820b73c2f9b818239c4
Autor:
Anna Uzonyi, David Dierks, Ronit Nir, Oh Sung Kwon, Ursula Toth, Isabelle Barbosa, Cindy Burel, Alexander Brandis, Walter Rossmanith, Hervé Le Hir, Boris Slobodin, Schraga Schwartz
Publikováno v:
Molecular cell.
N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-uniformly distributed across the transcriptome, yet the basis for its selective deposition is unknown. Here, we propose that m6A deposition is not selective. Instead, it is exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce73dc6ab827697d8623bd5d7fe8c9f
https://pubmed.ncbi.nlm.nih.gov/36599352
https://pubmed.ncbi.nlm.nih.gov/36599352
Autor:
Ronit Nir, Thomas Philipp Hoernes, Hiromi Muramatsu, Klaus Faserl, Katalin Karikó, Matthias David Erlacher, Aldema Sas-Chen, Schraga Schwartz
Publikováno v:
Nucleic acids research. 50(9)
RNA can be extensively modified post-transcriptionally with >170 covalent modifications, expanding its functional and structural repertoire. Pseudouridine (Ψ), the most abundant modified nucleoside in rRNA and tRNA, has recently been found within mR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140901e473f6374fa77f1be754f420ec
https://pubmed.ncbi.nlm.nih.gov/35536311
https://pubmed.ncbi.nlm.nih.gov/35536311
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2192
RNA modifications are present in most cellular RNAs and are formed posttranscriptionally by enzymatic machineries that involve hundreds of enzymes and cofactors. RNA modifications impact the life cycle of the RNA, its stability, folding, cellular loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abb0f84f2bbe53c005ab46af743f1da0
https://pubmed.ncbi.nlm.nih.gov/33230769
https://pubmed.ncbi.nlm.nih.gov/33230769
Autor:
Chloe A. Briney, Ran Shachar, Sunny Sharma, Jordan L. Meier, Jesse Hartmann, Yuko Nobe, Thomas J. Santangelo, Ronit Nir, Keri M Bryson, Brett W. Burkhart, Toshiaki Isobe, Justin M. Thomas, Geraldy L. S. Liman, Masato Taoka, Ryan T. Fuchs, Laurence Florens, Schraga Schwartz, Kellie D. Nance, Qishan Lin, Aldema Sas-Chen, Moran Shalev-Benami, G. Brett Robb, Michael P. Washburn, Supuni Thalalla Gamage, Michaella J. Levy, Donna Matzov
Publikováno v:
Nature
N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA1–3. However, the distribution, dynamics and functions of cytidine acetylation have y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea11713b3b0dd3ec5d1a1c32d7e40304
Autor:
Ofir Shliefer, Noam Stern-Ginossar, Anna Uzonyi, Schraga Schwartz, Yonatan Stelzer, Ronit Nir, Erez Y. Levanon, Yaron E. Antebi
Publikováno v:
Molecular Cell. 81:2374-2387.e3
Adenosine-to-inosine editing is catalyzed by ADAR1 at thousands of sites transcriptome-wide. Despite intense interest in ADAR1 from physiological, bioengineering, and therapeutic perspectives, the rules of ADAR1 substrate selection are poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a2d8430ec9ebf7269d7e96e9d2be75
https://doi.org/10.1016/j.molcel.2021.03.024
https://doi.org/10.1016/j.molcel.2021.03.024