Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Ronil Patel"'
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Akademický článek
Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells
Autor: Stanley F. Bazarek, Mentor Thaqi, Patrick King, Amol R. Mehta, Ronil Patel, Clark A. Briggs, Emily Reisenbigler, Jonathon E. Yousey, Elis A. Miller, Grace E. Stutzmann, Robert A. Marr, Daniel A. Peterson
Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)
Adult tissue stem cells contribute to tissue homeostasis and repair but the long-lived neurons in the human adult cerebral cortex are not replaced, despite evidence for a limited regenerative response. However, the adult cortex contains a population
Externí odkaz: https://doaj.org/article/73fb503078e64d9f8f65f691539b2b12
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Second-Generation Human Immunodeficiency Virus Integrase Inhibitors Induce Differentiation Dysregulation and Exert Toxic Effects in Human Embryonic Stem Cell and Mouse Models
Autor: Marie-Soleil R Smith, Haneesha Mohan, Abhinav Ajaykumar, Anthony Y Y Hsieh, Lou Martineau, Ronil Patel, Izabella Gadawska, Christopher Sherwood, Lena Serghides, James M Piret, Hélène C F Côté
Publikováno v: J Infect Dis
Background Each year, approximately 1.1 million children are exposed in utero to human immunodeficiency virus antiretrovirals, yet their safety is often not well characterized during pregnancy. The Tsepamo study reported a neural tube defect signal i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76017f204e4f83ef3047c6304ac145b0
https://doi.org/10.1093/infdis/jiac386
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Regional Anesthesia in the Combat Setting: Are ACGME Requirements Enough?
Autor: James K. Aden, Daniel M Nguyen, Robert H. Burch, Ronil Patel, Sandeep T Dhanjal, Chester C. Buckenmaier, Christopher V. Maani, Danielle M Santos, Krista B. Highland
Publikováno v: Military Medicine. 184:745-749
IntroductionUpdated Joint Trauma System Clinical Practice Guidelines (CPG) indicate regional anesthesia and pain management (RAAPM) are important for combat casualty care. However, it is unclear whether military anesthesiology residents are receiving
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc11cce53b8948a9492cc7a73addb0f
https://doi.org/10.1093/milmed/usz007
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Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation
Autor: Harshani R. Lawrence, Ernst Schönbrunn, Ronil Patel, Yunting Luo, Said M. Sebti, Nicholas J. Lawrence, Harsukh Gevariya, Uwe Rix, Hua Yang, Aslamuzzaman Kazi
Publikováno v: Oncotarget
$('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); Hua Yang 1 , Harshani R. Lawrence 3 , Aslamuzzaman Kazi 1 , Harsukh Gevariya 1 , Ronil Patel 1 , Yunting Luo 3 , Uwe Rix 1 , 2 , 4 , Ernst Schonbrunn 1 , 2 , 4 , Nicholas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850badda5324af5348af523740ef7783
https://doi.org/10.18632/oncotarget.1615
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Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities
Autor: Ronil Patel, Said M. Sebti, Binglin Wang, Yan Liu, Rongshi Li
Publikováno v: Oncogene
ROCK1 and ROCK2 mediate important processes such as cell migration, invasion and metastasis, making them good targets for the development of antitumor agents. Recently, using a fragment-based approach and X-ray crystallography, we reported on the des
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbd593fb6e07684c3b97a99c9efd4f5
https://doi.org/10.1038/onc.2012.634
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6
RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Autor: Nan Sun, Ronil Patel, Said M. Sebti, Ying Sun, Roberta Pireddu, Kara D. Forinash, Ernst Schönbrunn, Mathew P. Martin, Nicholas J. Lawrence
Publikováno v: Cancer Research. 72:5025-5034
The Rho-associated kinases ROCK1 and ROCK2 are critical for cancer cell migration and invasion, suggesting they may be useful therapeutic targets. In this study, we describe the discovery and development of RKI-1447, a potent small molecule inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d2bee5c8f4b9dffbd8e763d8bbcc63
https://doi.org/10.1158/0008-5472.can-12-0954
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7
Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors
Autor: Nicholas J. Lawrence, Ronil Patel, Jiannong Li, Roberta Pireddu, Said M. Sebti, Eric B. Haura, Ernst Schönbrunn, Rongshi Li, Mathew P. Martin, Wayne C. Guida, Jin-Yi Zhu, Shen Shu Sung, Yan Liu, Binglin Wang, Nan Sun
Publikováno v: Journal of Medicinal Chemistry. 55:2474-2478
Using high concentration biochemical assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 was equipotent for ROCK1 (IC(50) = 650 nM) and ROCK2 (IC(50) = 670 nM), wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dddbb3f59bb4df4a03c3a56c709450
https://doi.org/10.1021/jm201289r
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10
Akt2 and acid ceramidase cooperate to induce cell invasion and resistance to apoptosis
Autor: Norbert Berndt, Said M. Sebti, Maria E. Balasis, Ronil Patel, Hua Yang
Both Akt 2 and acid ceramidase (ASAH1) are found aberrantly overexpressed in cancer cells, but whether these two enzymes cooperate to induce malignant transformation is not known. We found that in immortalized, non-transformed cells, ectopic co-expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1941362360ebccd45698b0753fce58
https://europepmc.org/articles/PMC3737305/
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