Exercise Hemodynamics and Mitochondrial Oxidative Capacity in Disease Stages of Wild‐Type Transthyretin Amyloid Cardiomyopathy

Autor: Bertil Ladefoged, Anders Dahl Pedersen, Jacob Seefeldt, Bent Roni Ranghøj Nielsen, Hans Eiskjær, Emil Lichscheidt, Tor Clemmensen, Julian David Gillmore, Steen Hvitfeldt Poulsen

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)

Background Wild‐type transthyretin amyloid (ATTRwt) cardiomyopathy is increasingly recognized in the development of heart failure. The link between cardiac performance, hemodynamics, and mitochondrial function in disease stages of ATTRwt has not pr

Externí odkaz: https://doaj.org/article/36e4897fdd884b93ac55e5daa71d5e5b

Investigating effects of sodium beta‐hydroxybutyrate on metabolism in placebo‐controlled, bilaterally infused human leg with focus on skeletal muscle protein dynamics

Autor: Henrik Holm Thomsen, Jonas Franck Olesen, Rasmus Aagaard, Bent Roni Ranghøj Nielsen, Thomas Schmidt Voss, Mads Vandsted Svart, Mogens Johannsen, Niels Jessen, Jens Otto L. Jørgensen, Nikolaj Rittig, Ermina Bach, Niels Møller

Publikováno v: Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)

Abstract Systemic administration of beta‐hydroxybutyrate (BHB) decreases whole‐body protein oxidation and muscle protein breakdown in humans. We aimed to determine any direct effect of BHB on skeletal muscle protein turnover when administered loc

Externí odkaz: https://doaj.org/article/8132f763b5bd45d786d79ddae11579b7

Myocardial perfusion imaging by 15O-H2O positron emission tomography predicts clinical revascularization procedures in symptomatic patients with previous coronary artery bypass graft

Autor: Mazen Vester, Simon Madsen, Mette Louise Gram Kjærulff, Lars Poulsen Tolbod, Bent Roni Ranghøj Nielsen, Steen Dalby Kristensen, Evald Høj Christiansen, Per Hostrup Nielsen, Jens Sörensen, Lars Christian Gormsen

Publikováno v: Vester, M, Madsen, S, Kjærulff, M L G, Tolbod, L P, Nielsen, B R R, Kristensen, S D, Christiansen, E H, Nielsen, P H, Sörensen, J & Gormsen, L C 2023, ' Myocardial perfusion imaging by 15O-H 2O positron emission tomography predicts clinical revascularization procedures in symptomatic patients with previous coronary artery bypass graft. ', European Heart Journal Open, vol. 3, no. 3, pp. oead044 . https://doi.org/10.1093/ehjopen/oead044

Aims We wanted to assess if 15O-H2O myocardial perfusion imaging (MPI) in a clinical setting can predict referral to coronary artery catheterization [coronary angiography (CAG)], execution of percutaneous coronary intervention (PCI), and post-PCI ang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bf9e61c5e9d4c5f3d96f5592d5e303
https://doi.org/10.1093/ehjopen/oead044

SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial

Autor: Henrik Wiggers, Niels Møller, Jakob Hansen, Bent Roni Ranghøj Nielsen, Katrine M Lauritsen, Troels Krarup Hansen, Mogens Johannsen, Lars Poulsen Tolbod, Lars C. Gormsen, Esben Søndergaard

Publikováno v: Lauritsen, K M, Nielsen, B R R, Tolbod, L P, Johannsen, M, Hansen, J, Hansen, T K, Wiggers, H, Møller, N, Gormsen, L C & Søndergaard, E 2021, ' SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, But Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes-a Randomized Double-Blind, Placebo-Controlled Crossover Trial ', Diabetes, vol. 70, no. 3, pp. 800-808 . https://doi.org/10.2337/db20-0921

Sodium-glucose cotransporter 2 (SGLT2) inhibition reduces cardiovascular morbidity and mortality in individuals with type 2 diabetes. Beneficial effects have been attributed to increased ketogenesis, reduced cardiac fatty acid oxidation and diminishe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314259642f5634dd488aefc29498f6e1
https://doi.org/10.2337/db20-0921

Echocardiographic parameters during prolonged targeted temperature Management in out-of-hospital Cardiac Arrest Survivors to predict neurological outcome - a post-hoc analysis of the TTH48 trial

Autor: Thomas Hvid Jensen, Hans Kirkegaard, Bent Roni Ranghøj Nielsen, Johan Heiberg, Christophe Henri Valdemar Duez, Peter Juhl-Olsen, Anni Nørgaard Jeppesen, Anders Morten Grejs, Christian Alcaraz Frederiksen

Publikováno v: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Jensen, T H, Juhl-Olsen, P, Nielsen, B R R, Heiberg Engel, P J, Duez, C H V, Jeppesen, A N, Frederiksen, C A, Kirkegaard, H & Grejs, A M 2021, ' Echocardiographic parameters during prolonged targeted temperature Management in out-of-hospital Cardiac Arrest Survivors to predict neurological outcome – a post-hoc analysis of the TTH48 trial ', Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 29, no. 1, 37 . https://doi.org/10.1186/s13049-021-00849-7
Jensen, T H, Juhl-Olsen, P, Nielsen, B R R, Heiberg, J, Duez, C H V, Jeppesen, A N, Frederiksen, C A, Kirkegaard, H & Grejs, A M 2021, ' Echocardiographic parameters during prolonged targeted temperature Management in out-of-hospital Cardiac Arrest Survivors to predict neurological outcome – a post-hoc analysis of the TTH48 trial ', Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol. 29, no. 1, 37 . https://doi.org/10.1186/s13049-021-00849-7
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 29, Iss 1, Pp 1-10 (2021)

Background Transthoracic echocardiographic (TTE) indices of myocardial function among survivors of out-of-hospital cardiac arrest (OHCA) have been related to neurological outcome; however, results are inconsistent. We hypothesized that changes in ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a8d5f0dbd3b04319d9c20b8960c1f3
https://pubmed.ncbi.nlm.nih.gov/33608045