Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Roni Oren"'
Autor:
Arturo Simoni-Nieves, Moshit Lindzen, Suvendu Giri, Nitin Gupta, Rishita Chatterjee, Boobash-Raj Selvadurai, Marieke Van Daele, Danielle Love, Yuya Haga, Donatella Romaniello, Tomer-Meir Salame, Mirie Zerbib, Roni Oren, Yasuo Tsutsumi, Mattia Lauriola, Ilaria Marrocco, Yosef Yarden
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101703- (2024)
Summary: Activating EGFR (epidermal growth factor receptor) mutations can be inhibited by specific tyrosine kinase inhibitors (TKIs), which have changed the landscape of lung cancer therapy. However, due to secondary mutations and bypass receptors, s
Externí odkaz:
https://doaj.org/article/92b1210a06874d6d8474c3fe51ec1d80
Autor:
Danielle Algranati, Roni Oren, Bareket Dassa, Liat Fellus-Alyagor, Alexander Plotnikov, Haim Barr, Alon Harmelin, Nir London, Guy Ron, Noa Furth, Efrat Shema
Publikováno v:
eLife, Vol 13 (2024)
Diffuse midline gliomas (DMGs) are aggressive and fatal pediatric tumors of the central nervous system that are highly resistant to treatments. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, resh
Externí odkaz:
https://doaj.org/article/d63328b5980f4190895f7d76cb98e2cf
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10781-10790 (2023)
Abstract Background Proteasome inhibitors are in use in treating certain types of cancers. These drugs inhibit the catalytic activity of the 20S proteasome, shared by all the different proteasome complexes. Inhibitors of the 26S‐associated deubiqui
Externí odkaz:
https://doaj.org/article/cefcef473a1e4113b0a1711449776b6d
Autor:
Pragati K. Prasad, Noa Eizenshtadt, Inna Goliand, Liat Fellus-Alyagor, Roni Oren, Ofra Golani, Leila Motiei, David Margulies
Publikováno v:
Materials Today Bio, Vol 20, Iss , Pp 100669- (2023)
Common methods to label cell surface proteins (CSPs) involve the use of fluorescently modified antibodies (Abs) or small-molecule-based ligands. However, optimizing the labeling efficiency of such systems, for example, by modifying them with addition
Externí odkaz:
https://doaj.org/article/3b84f0dd00f44e488e75b0b7e3076828
Autor:
Karin Eytan, Ziv Versano, Roni Oren, Jasmine Jacob-Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Amos Toren, Shoshana Paglin, Michal Yalon
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing the H3G34R mutation are sensitive to the combination of vorinostat (a hi
Externí odkaz:
https://doaj.org/article/94ed604ed6f041fd98ae25564cb832bc
Autor:
Rotem Ben-Hamo, Adi Jacob Berger, Nancy Gavert, Mendy Miller, Guy Pines, Roni Oren, Eli Pikarsky, Cyril H. Benes, Tzahi Neuman, Yaara Zwang, Sol Efroni, Gad Getz, Ravid Straussman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Predicting an individual's response to therapy is an important goal for precision medicine. Here, the authors use an algorithm that takes into account the interaction type and directionality of signalling pathways in protein–protein interactions an
Externí odkaz:
https://doaj.org/article/af440b4d64314959a421c75b7dfbd17b
Autor:
Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A. Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The response to immunotherapy of melanoma patients is heterogeneous. Here, the authors demonstrate that a high expression of the two major components of the immunoproteasome, PSMB8 and PSMB9, modulates the production of HLA peptides and it is predict
Externí odkaz:
https://doaj.org/article/c5c1da08d4014458bca5479e40d5cf1c
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models
Autor:
Ilaria Marrocco, Donatella Romaniello, Itay Vaknin, Diana Drago‐Garcia, Roni Oren, Mary Luz Uribe, Nishanth Belugali Nataraj, Soma Ghosh, Raya Eilam, Tomer‐Meir Salame, Moshit Lindzen, Yosef Yarden
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Some antibacterial therapies entail sequential treatments with different antibiotics, but whether this approach is optimal for anti‐cancer tyrosine kinase inhibitors (TKIs) remains open. EGFR mutations identify lung cancer patients who can
Externí odkaz:
https://doaj.org/article/f40e6d84396d426eb6294535a2d589ba
Autor:
Roni Oren, Liat Fellus-Alyagor, Yoseph Addadi, Filip Bochner, Hila Gutman, Shani Blumenreich, Hagit Dafni, Nava Dekel, Michal Neeman, Shlomi Lazar
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Thin section histology is limited in providing 3D structural information, particularly of the intricate morphology of the vasculature. Availability of high spatial resolution imaging for thick samples, would overcome the restriction dictated
Externí odkaz:
https://doaj.org/article/6f54c7ca5d874fb798a1a7df2d40a6fe
Publikováno v:
Cancer Medicine. 12:10781-10790