Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Roni Chau"'
Autor:
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick CG Haddick, Kirk R Henne, Martin Larhammar, Amy W-S Leung, Romeo Maciuca, Bahram Memarzadeh, Hoang N Nguyen, Alicia A Nugent, Maksim Osipov, Yingqing Ran, Kevin Rebadulla, Elysia Roche, Thomas Sandmann, Jing Wang, Joseph W Lewcock, Kimberly Scearce-Levie, Lesley A Kane, Pascal E Sanchez
Publikováno v:
eLife, Vol 12 (2024)
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores cellular homeostasis, intense or prolonged ISR ac
Externí odkaz:
https://doaj.org/article/6521500dd1424027bebffc6920eba56b
Autor:
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnörich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified decades ago, but the field is still in search of transformative therapies for patients. While mouse models based on overexpression of mutated transge
Externí odkaz:
https://doaj.org/article/9eb417ef38964cb082e476c72c827f5f
Autor:
Robert A. Craig, Brian M. Fox, Cheng Hu, Katrina W. Lexa, Maksim Osipov, Arun P. Thottumkara, Martin Larhammar, Takashi Miyamoto, Anil Rana, Lesley A. Kane, Ernie Yulyaningsih, Hilda Solanoy, Hoang Nguyen, Roni Chau, Timothy Earr, Yuji Kajiwara, Daniel Fleck, Anthony Lucas, Patrick C. G. Haddick, Ryan H. Takahashi, Vincent Tong, Jing Wang, Mark J. Canet, Suresh B. Poda, Kimberly Scearce-Levie, Ankita Srivastava, Zachary K. Sweeney, Musheng Xu, Rui Zhang, Jianrong He, Yanan Lei, Zheng Zhuo, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 65:16290-16312
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative diseases. Herein, we
Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme
Autor:
Annie Arguello, Cathal S. Mahon, Meredith E.K. Calvert, Darren Chan, Jason C. Dugas, Michelle E. Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A. Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C. Ullman, Junhua Wang, Mark S. Dennis, Dolores Diaz, Kannan Gunasekaran, Kirk R. Henne, Joseph W. Lewcock, Pascal E. Sanchez, Matthew D. Troyer, Jeffrey M. Harris, Kimberly Scearce-Levie, Lu Shan, Ryan J. Watts, Robert G. Thorne, Anastasia G. Henry, Mihalis S. Kariolis
Publikováno v:
Journal of Experimental Medicine. 219
Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytos
Autor:
Ryan J. Watts, Kathryn M. Monroe, Junhua Wang, Melina Lenser, Jennifer Hsiao-Nakamoto, Hoang Nguyen, Todd P. Logan, Do Jin Kim, Fen Huang, Ritesh Ravi, Gilbert Di Paolo, Anil Rana, Kannan Gunasekaran, Yaneth Robles-Colmenares, Gerald M. Cherf, Buyankhishig Tsogtbaatar, Ceyda Llapashtica, Kirk R. Henne, Hilda Solanoy, Pascal E. Sanchez, Yashas Rajendra, Mihalis Kariolis, Ray Lieh Yoon Low, Roni Chau, Laralynne Przybyla, Michelle E. Pizzo, Chi-Lu Chiu, Meng Fang, Anastasia G. Henry, Giuseppe Astarita, Mark S. Dennis, Adam L. Boxer, Sarah L. DeVos, Sonnet S. Davis, Hilary W. Heuer, René Meisner, Joseph W. Lewcock, Devendra B. Srivastava, Bradley F. Boeve, Meredith E. K. Calvert, Katrina W. Lexa, Rachel Prorok, Lukas L. Skuja, Dolores Diaz, Akhil Bhalla, Matthew Simon, Jung H. Suh, Ankita Srivastava, Timothy K. Earr, Howard J. Rosen, Joseph Duque, Bettina Van Lengerich, Elizabeth W. Sun
Publikováno v:
Cell
Cell, vol 184, iss 18
Cell, vol 184, iss 18
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn(−/−) mice exhibit a global deficiency in bis(monoacylglycero)phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8760616b55660b5a69ea73b7ad6da
https://europepmc.org/articles/PMC8489356/
https://europepmc.org/articles/PMC8489356/
Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme
Autor:
Kirk R. Henne, Kimberly Scearce-Levie, Annie Arguello, Ullman Julie, Mihalis Kariolis, Tina Giese, Jeffrey M. Harris, Matthew D. Troyer, Kannan Gunasekaran, Meredith E. K. Calvert, Dolores Diaz, Anastasia G. Henry, Elliot R. Thomsen, Buyankhishig Tsogtbaatar, Roni Chau, Isabel Lopez, Joseph W. Lewcock, Cathal Mahon, Michelle E. Pizzo, Lu Shan, Darren Chan, Meng Fang, Pascal E. Sanchez, Robert G. Thorne, Timothy K. Earr, Ryan J. Watts, Joseph Duque, Lorna A. Damo, Mark S. Dennis, Hoang N. Nguyen, Do Jin Kim, Junhua Wang, Nicholas Liang, Hilda Solanoy, Jason C. Dugas
Delivery of biotherapeutics across the blood-brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae90ba1655eaabdb89b5f77c6a55a6f
https://doi.org/10.1101/2021.05.21.445035
https://doi.org/10.1101/2021.05.21.445035
Autor:
Dylan Garceau, Jennifer D. Whitesell, Julie A. Harris, Hilda Solanoy, Hoang Nguyen, Gilbert Di Paolo, Connie W.Y. Ha, Robert G. Thorne, Meredith E. K. Calvert, Joseph W. Lewcock, Karin Lin, Roni Chau, Thomas Sandmann, Sarah L. DeVos, Steve Lianoglou, Michael Sasner, Michelle E. Pizzo, Richard H. Liang, Jason C. Dugas, Jung H. Suh, Elliot R. Thomsen, Timothy K. Earr, Chia-Ching Lin, Kimberly Scearce-Levie, Dan Xia, Sonnet S. Davis, Shababa T. Masoud, Pascal E. Sanchez, Ernie Yulyaningsih
Microglial dysfunction is believed to play a pathogenic role in Alzheimer’s disease (AD). Here, we characterize the amyloid-β related pathology and microglial responses in an engineered APP knock-in mouse model of familial AD. This model recapitul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740621cd30fb1a8feec1aa4ace66f9b6
https://doi.org/10.1101/2021.01.19.426731
https://doi.org/10.1101/2021.01.19.426731
Autor:
Hoang Nguyen, Elizabeth Sun, Yashas Rajendra, Gerald Maxwell Cherf, Jennifer Hsiao-Nakamoto, Todd P. Logan, Joseph Duque, Anil Rana, Fen Huang, Matthew J. Simon, Kannan Gunasekaran, Pascal E. Sanchez, Junhua Wang, Mihalis Kariolis, Kirk R. Henne, Zachary Kevin Sweeney, Sofia Mosesova, Sonnet S. Davis, Bettina Van Lengerich, Do Jin Kim, Hai L. Tran, Rachel Prorok, Darren Chan, Mark S. Dennis, Kathryn M. Monroe, Yuda Zhu, Ray Low, Akhil Bhalla, Gilbert Di Paolo, Ankita Srivastava, Giuseppe Astarita, Timothy K. Earr, Joseph W. Lewcock, Roni Chau, Sarah L. DeVos, Ryan J. Watts, Melina Lenser
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
The FASEB Journal. 26