Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rongze Olivia Lu"'
Autor:
Mary C. Clark, Rongze Olivia Lu, Winson S. Ho, Matheus Henrique Dias, René Bernards, Stephen J. Forman
Publikováno v:
Molecular Oncology, Vol 18, Iss 10, Pp 2333-2337 (2024)
Immune checkpoint blockade has emerged as a potent new tool in the war on cancer. However, only a subset of cancer patients benefit from this therapeutic modality, sparking a search for combination therapies to increase the fraction of responding pat
Externí odkaz:
https://doaj.org/article/08b55194efba462da941ad233f0a4083
Autor:
Zhuhao Wu, Zheng Ao, Hongwei Cai, Xiang Li, Bin Chen, Honglei Tu, Yijie Wang, Rongze Olivia Lu, Mingxia Gu, Liang Cheng, Xin Lu, Feng Guo
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Cancer immunotherapy shows promising potential for treating breast cancer. While patients may have heterogeneous treatment responses for adjuvant therapy, it is challenging to predict an individual patient’s response to cancer immunotherap
Externí odkaz:
https://doaj.org/article/681412411ac64529a06a805cee72a4a8
Autor:
Winson S. Ho, Isha Mondal, Beisi Xu, Oishika Das, Raymond Sun, Pochin Chiou, Xiaomin Cai, Foozhan Tahmasebinia, Elizabeth McFadden, Caren Yu-Ju Wu, Zhihao Wu, William Matsui, Michael Lim, Zhipeng Meng, Rongze Olivia Lu
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Stimulator of IFN genes type I (STING-Type I) IFN signaling in myeloid cells plays a critical role in effective antitumor immune responses, but STING agonists as monotherapy have shown limited efficacy in clinical trials. The mechanisms that downregu
Externí odkaz:
https://doaj.org/article/9d2712bd859049a58446ca2f3c8ebbb8
Autor:
Yunpeng Huang, Zhihui Wan, Yinglu Tang, Junxuan Xu, Bretton Laboret, Sree Nallamothu, Chenyu Yang, Boxiang Liu, Rongze Olivia Lu, Bingwei Lu, Juan Feng, Jing Cao, Susan Hayflick, Zhihao Wu, Bing Zhou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
PKAN and PD are two distinct diseases with overlapping pathophysiology. Here, authors show that their pathogenic genes PANK2 and PINK1 interact. PANK2 regulates mitophagy via CoA metabolism, while PINK1 supervises PANK2 translation on mitochondria.
Externí odkaz:
https://doaj.org/article/16fc36f4356c4cb58aa17e45fb7b1b26
Autor:
Rongze Olivia Lu, Winson S. Ho
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Glioblastoma (GBM) is the most common malignant brain cancer. Increasing evidence suggests that mitochondrial dysfunction plays a key role in GBM progression as mitochondria is essential in regulating cell metabolism, oxidative stress, and cell death
Externí odkaz:
https://doaj.org/article/3c347484997a4bceb9dd4e242ba8c6b4
Autor:
Isha Mondal, Oishika Das, Raymond Sun, Jian Gao, Bohyeon Yu, Aaron Diaz, Jinan Behnan, Abhishek Dubey, Zhipeng Meng, Emad Eskandar, Beisi Xu, Rongze Olivia. Lu, Winson S. Ho
Publikováno v:
Cancer Research.
Glioblastoma (GBM) is an immunologically “cold” tumor that does not respond to current immunotherapy. Here, we demonstrate a fundamental role for the α-isoform of the catalytic subunit of protein phosphatase-2A (PP2Ac) in regulating glioma immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc43b757fa3450551859fb75515d3db8
https://doi.org/10.1158/0008-5472.can-22-3382
https://doi.org/10.1158/0008-5472.can-22-3382
Publikováno v:
Neuro Oncol
Checkpoint immunotherapy (ICB) thus far has shown limited efficacy against brain tumors, such as medulloblastoma (MB). Its low mutational burden is thought to result in a paucity of neoantigen to trigger an effective T-cell response. Natural killer (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed79b32e13cee270bc35ff4f02fc208
https://europepmc.org/articles/PMC7651112/
https://europepmc.org/articles/PMC7651112/
Autor:
Yunpeng Huang, Zhihui Wan, Yinglu Tang, Junxuan Xu, Bretton Laboret, Sree Nallamothu, Chenyu Yang, Boxiang Liu, Rongze Olivia Lu, Bingwei Lu, Juan Feng, Jing Cao, Susan Hayflick, Zhihao Wu, Bing Zhou
Publikováno v:
Nature communications. 13(1)
Human neurodegenerative disorders often exhibit similar pathologies, suggesting a shared aetiology. Key pathological features of Parkinson’s disease (PD) are also observed in other neurodegenerative diseases. Pantothenate Kinase-Associated Neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baced42be8b41877383251ee3c032bbc
https://pubmed.ncbi.nlm.nih.gov/35786295
https://pubmed.ncbi.nlm.nih.gov/35786295