Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Rongya Tao"'
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101703- (2023)
Objective: Body weight change and obesity follow the variance of excess energy input balanced against tightly controlled EE (energy expenditure). Since insulin resistance can reduce energy storage, we investigated whether genetic disruption of hepati
Externí odkaz:
https://doaj.org/article/95d2d99252ed4ec6817c94084abdae15
Autor:
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show tha
Externí odkaz:
https://doaj.org/article/718976e80f5648f99659b5ea904f47e5
Autor:
Mengyao Ella Li, Hans P. M. M. Lauritzen, Brian T. O’Neill, Chih-Hao Wang, Weikang Cai, Bruna B. Brandao, Masaji Sakaguchi, Rongya Tao, Michael F. Hirshman, Samir Softic, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Diabetes is associated with decreased PI3K activation in skeletal muscle. Here, the authors show that p110a is the predominant PI3K subunit in muscle, and show that its ablation in muscle, but not ablation of p110beta, leads to insulin resistance, in
Externí odkaz:
https://doaj.org/article/dd1ee7415b94490ba84eaa4f18e22335
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108893- (2021)
Summary: Fgf21 (fibroblast growth factor 21) is a regulatory hepatokine that, in pharmacologic form, powerfully promotes weight loss and glucose homeostasis. Although “Fgf21 resistance” is inferred from higher plasma Fgf21 levels in insulin-resis
Externí odkaz:
https://doaj.org/article/59d3d218444147f78a799541e8a70b29
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2745-2753 (2013)
Cholesterol homeostasis is crucial for cellular function and organismal health. The key regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein (SREBP)-2. The biochemical process and physiological function of SREBP-2 h
Externí odkaz:
https://doaj.org/article/bf53d7a77fde4148b87283476cac0cd8
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71997 (2013)
Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of the mitochondrial pyruvate dehydrogenase complex especially when blood glucose levels are low and pyruvate can be conserved for gluconeogenesis. Under diabetic conditio
Externí odkaz:
https://doaj.org/article/3b40615f220941d793df83f1fbc523f0
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74340 (2013)
Forkhead transcription factors FoxO1/3/4 have pleiotrophic functions including anti-oxidative stress and metabolism. With regard to glucose metabolism, most studies have been focused on FoxO1. To further investigate their hepatic functions, we genera
Externí odkaz:
https://doaj.org/article/068bb8e808a84ddb91913a1a0d2deb08
Autor:
Emily J Dhurandhar, Rashmi Krishnapuram, Vijay Hegde, Olga Dubuisson, Rongya Tao, X Charlie Dong, Jianping Ye, Nikhil V Dhurandhar
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47813 (2012)
Hepatic steatosis often accompanies obesity and insulin resistance. The cornerstones of steatosis treatment include reducing body weight and dietary fat intake, which are marginally successful over the long term. Ad36, a human adenovirus, may offer a
Externí odkaz:
https://doaj.org/article/d881abf1213546f7a18ee4b35ddce774
Autor:
Yoo Kim, Lee, Junsik M., Youngah Han, Rongya Tao, White, Morris F., Renyan Liu, Sang Won Park
Publikováno v:
Journal of Endocrinology; Sep2023, Vol. 258 Issue 3, p1-12, 12p
Autor:
Kyle D. Copps, Rongya Tao
Publikováno v:
Gastroenterology
BACKGROUND AND AIMS: Insulin signaling is known to regulate essential proteostasis mechanisms. METHODS: The analyses here examined effects of insulin-signaling in the PiZ mouse model of α1-antitrypsin deficiency (ATD) in which hepatocellular accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fec20b499ff547964d7b38b4ecf97d
https://doi.org/10.1053/j.gastro.2022.04.044
https://doi.org/10.1053/j.gastro.2022.04.044