Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rongtong Zhao"'
Autor:
Yuena Wang, Rongtong Zhao, Chuan Wan, Wei Kang, Rui Wang, Chengyao Chiang, Xiaochun Guo, Qi Chang, Zhanfeng Hou, Yuxin Ye, Qinhong Luo, Ziyuan Zhou, Jianbo Liu, Shuiming Li, Dongyuan Wang, Feng Yin, Zigang Li
Publikováno v:
CCS Chemistry. 5:1433-1442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6dbcac2299160f2b43e800ee1b40af
https://doi.org/10.31635/ccschem.022.202201985
https://doi.org/10.31635/ccschem.022.202201985
Autor:
Yuena Wang, Rongtong Zhao, Chuan Wan, Xiaochun Guo, Fenfang Yang, Zhanfeng Hou, Rui Wang, Shuiming Li, Tiejian Feng, Feng Yin, Zigang Li
Publikováno v:
Organic Letters. 24:7205-7209
The ligand-directed (LD) chemistry provides powerful tools for site-specific modification of proteins. We utilized a peptide with an appended methionine (Met) as a ligand; then, the Met thioether was modified into sulfonium which enabled a proximity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f30c4e1183e40966072662f03475e5
https://doi.org/10.1021/acs.orglett.2c02974
https://doi.org/10.1021/acs.orglett.2c02974
Autor:
Zigang Li, Feng Yin, Wei Liang, Qi Fang, Fei Lu, Mingsheng Xie, Hui Zhao, Yuan Tian, Na Liu, Longjian Chen, Rongtong Zhao, Wenjun Li, Dongyuan Wang
Figure S1：HDAC distribution in HeLa cells. Figure S2：Enzyme activity of peptides in SIRT1. Figure S3: CD spectra of peptide 16cyc-HxA, 16lin-HxA, 13cyc-HxA and 13lin-HxA. Figure S4: Enzyme activity of peptides in HDAC1, 3, 6, 8. Figure S5:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f71f2c8420e66d68612e4c051138cd
https://doi.org/10.1158/0008-5472.22422306.v1
https://doi.org/10.1158/0008-5472.22422306.v1
Autor:
Zigang Li, Feng Yin, Wei Liang, Qi Fang, Fei Lu, Mingsheng Xie, Hui Zhao, Yuan Tian, Na Liu, Longjian Chen, Rongtong Zhao, Wenjun Li, Dongyuan Wang
FDA-approved HDAC inhibitors exhibit dose-limiting adverse effects; thus, we sought to improve the therapeutic windows for this class of drugs. In this report, we describe a new class of peptide-based HDAC inhibitors derived from the HDAC1-specific s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c86f68b601c489fc5f1f8a63c10cf4
https://doi.org/10.1158/0008-5472.c.6511176
https://doi.org/10.1158/0008-5472.c.6511176
Autor:
Zigang Li, Rongtong Zhao, Na Liu, Di Li, Licheng Tu, Chenshan Lian, Feng Yin, Shuiming Li, Jianbo Liu, Huilin Zhu, Yichi Zhang, Mengying Yu, Chuan Wan, Dongyuan Wang
Publikováno v:
ChemBioChem. 22:340-344
Anti-apoptotic B cell lymphoma 2 (BCL-2) family proteins are proven targets for human cancers. Targeting the BH3-binding pockets of these anti-apoptotic proteins could reactivate apoptosis in BCL-2-depedent cancers. BFL-1 is a BCL-2 family protein ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102877d81b1785c20c7d4db80f51d8c5
https://doi.org/10.1002/cbic.202000473
https://doi.org/10.1002/cbic.202000473
Autor:
Feng Yin, Rongtong Zhao, Chenshan Lian, Zhanfeng Hou, Yang Li, Chuan Wan, Zigang Li, Yue Ma, Dongyuan Wang
Publikováno v:
The Journal of Organic Chemistry. 85:1698-1705
We report a facile thiol-yne type reaction triggered by the sulfonium center. After facile propargylation of thiolethers, the resulting sulfonium could undergo facile addition with thiols in aqueous media at ambient temperature. Further applying this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957355a8f06286c142c656f7199a4637
https://doi.org/10.1021/acs.joc.9b02505
https://doi.org/10.1021/acs.joc.9b02505
Autor:
Zigang Li, Rui Wang, Shuiming Li, Feng Yin, Dongyuan Wang, Yang Li, Chuan Wan, Rongtong Zhao, Wanjin Zhong, Chenshan Lian, Wang Yuena, Zhanfeng Hou
Publikováno v:
Chemical Communications. 56:3741-3744
Continuous efforts have been invested in the selective modification of proteins. Herein, we first report the construction of sulfonium tethered cyclic peptides via an intramolecular cyclization by an aliphatic halide. This cyclization could enhance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d3de6fd677d1671005dec3b374afdf
https://doi.org/10.1039/d0cc00377h
https://doi.org/10.1039/d0cc00377h
Publikováno v:
Journal of peptide science : an official publication of the European Peptide SocietyREFERENCES. 28(3)
Herein, we report a novel strategy for diversity-oriented lysine modification of cyclic peptides based on the orthogonal alkylation of the lysine residues. All steps can be achieved in the solid phase with satisfying conversions. Notably, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0450ca8ab7b3a603e4b1d68209782158
https://pubmed.ncbi.nlm.nih.gov/34643009
https://pubmed.ncbi.nlm.nih.gov/34643009
Publikováno v:
Current Topics in Medicinal Chemistry. 18:2380-2394
Epigenetics process is the heritable change in gene function that does not involve changes in the DNA sequence. Until now, several types of epigenetic mechanisms have been characterized, including DNA methylation, histone modification (acetylation, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e916ec3bbec95585f546afd3ee187f
https://doi.org/10.2174/1568026618666181115092623
https://doi.org/10.2174/1568026618666181115092623
Autor:
Xuan Qin, Rongtong Zhao, Meimiao Zhan, Yue Ma, Ziyuan Zhou, Xiaodong Shi, Licheng Tu, Feng Yin, Zigang Li
Publikováno v:
Chemical Communications. 55:4198-4201
Peptides that induced autophagy at micromolar concentrations with improved proteolytic resistance properties were generated using the facile methionine bis-alkylation method. Notably, a short bicyclic peptide 7f was proven to be the most potent one a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aadc4ec751575c9bcc258715b702aa2
https://doi.org/10.1039/c9cc01027k
https://doi.org/10.1039/c9cc01027k