Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex

Autor: Rodolfo Ghirlando, Myung Soo Lee, Kiyoshi Mizuuchi, Michael Krause, Robert Craigie, Ronglan Zheng

Publikováno v: Proceedings of the National Academy of Sciences. 97:8997-9002

Barrier-to-autointegration factor (BAF) is a highly conserved cellular protein that was identified by its activity in protecting retroviral DNA against autointegration. We show that BAF has the property of bridging double-stranded DNA in a highly ord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db0620e1df3696b782fffb5ecc230cc
https://doi.org/10.1073/pnas.150240197

Solution structure of the His12 --Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium

Autor: Michael Caffrey, Angela M. Gronenborn, G M Clore, Ronglan Zheng, Mengli Cai, Ying Huang, Robert Craigie

Publikováno v: Protein science : a publication of the Protein Society. 7(12)

The solution structure of His12 --> Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3242998f47cc34c0460af8264defc30
https://pubmed.ncbi.nlm.nih.gov/9865962

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

Autor: Timothy M. Jenkins, Ronglan Zheng, Robert Craigie

The N-terminal domain of HIV-1 integrase contains a pair of His and Cys residues (the HHCC motif) that are conserved among retroviral integrases. Although His and Cys residues are often involved in binding zinc, the HHCC motif does not correspond to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d0d996d6a75379f05dc1bcd7393b51
https://europepmc.org/articles/PMC19383/

Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein...

Autor: Ronglan Zheng, Ghirlando, Rodolfo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 08/01/2000, Vol. 97 Issue 16, p8997, 6p, 5 Diagrams, 1 Chart, 1 Graph