Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Rongguang Shao"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4477-4501 (2023)
Pancreatic cancer is a more aggressive and refractory malignancy. Resistance and toxicity limit drug efficacy. Herein, we report a lower toxic and higher effective miriplatin (MPt)-loaded liposome, LMPt, exhibiting totally different anti-cancer mecha
Externí odkaz:
https://doaj.org/article/305575cea9d248b19b2d3281f69a6827
Autor:
Wenxia Zhao, Yang Li, Hanzeng Cheng, Mengyan Wang, Zhishuo Zhang, Meilian Cai, Cong Zhao, Xiaoming Xi, Xiaojun Zhao, Wuli Zhao, Yajun Yang, Rongguang Shao
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Myofibrillogenesis regulator‐1 (MR‐1) is a multifunctional protein involved in the development of various human tumors. The study is the first to report the promoting effect of MR‐1 on the development and metastasis of non‐small cell
Externí odkaz:
https://doaj.org/article/0848ec5f7520484f947659108b28ccce
Publikováno v:
Cells, Vol 13, Iss 7, p 620 (2024)
Cancer stem cells (CSCs) are closely associated with tumor initiation, metastasis, chemoresistance, and recurrence, which represent some of the primary obstacles to cancer treatment. Targeting CSCs has become an important therapeutic approach to canc
Externí odkaz:
https://doaj.org/article/c49978ae0b2246748ebfb295b4f50e07
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Inflammation primarily influences the initiation, progression, and deterioration of many human diseases, and immune cells are the principal forces that modulate the balance of inflammation by generating cytokines and chemokines to maintain physiologi
Externí odkaz:
https://doaj.org/article/f084e6756a6f415b859b16aff8a770fa
Autor:
Wenxia Zhao, Conghui Zhang, Yiming Li, Yang Li, Yang Liu, Xiaoyu Sun, Mingyan Liu, Rongguang Shao
Publikováno v:
Hematology, Vol 27, Iss 1, Pp 367-378 (2022)
Purpose The prognostic role of TET2 and/or ASXL1 mutations which are common gene mutations in chronic myelomonocytic leukemia (CMML) remains controversial. Therefore, we conducted this meta-analysis to evaluate the prognostic efficacy of ASXL1 and TE
Externí odkaz:
https://doaj.org/article/aa6fea9a2b2a48859626bbf84d532595
Autor:
Hongjuan Yao, Wenping Song, Rui Cao, Cheng Ye, Li Zhang, Hebing Chen, Junting Wang, Yuchen Shi, Rui Li, Yi Li, Xiujun Liu, Xiaofei Zhou, Rongguang Shao, Liang Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Chemoresistance is a main limitation for the treatment of pancreatic ductal adenocarcinoma (PDAC). Here, the authors show that an antibody drug conjugate-like compound targeting both EGFR and HER2 overcomes gemcitabine resistance in PDAC preclinical
Externí odkaz:
https://doaj.org/article/75334597bd7c4267a01e7477e95fe61e
Autor:
Zhishuo Zhang, Wenxia Zhao, Yiming Li, Yang Li, Hanzeng Cheng, Liyun Zheng, Xiaoyu Sun, Hao Liu, Rongguang Shao
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-20 (2022)
Abstract Background Ubiquitination is a basic post-translational modification of intracellular proteins and can be reversed enzymatically by DUBs (deubiquitinating enzymes). More than 90 DUBs have been identified. Among them, the deubiquitinating enz
Externí odkaz:
https://doaj.org/article/8d1778f6f5f74bbfa798e6d5963a8a11
Autor:
Junxia Wang, Minghua Chen, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Xiujun Liu, Meilian Cai, Yuhan Qiu, Tianshu Zhang, Huimin Zhou, Wuli Zhao, Shuyi Si, Rongguang Shao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 210-227 (2022)
Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fung
Externí odkaz:
https://doaj.org/article/8eb8e68df71f4206b0ca6ae01cae4616
Autor:
Tianshu Zhang, Huimin Zhou, Kexin Wang, Xiaowei Wang, Mengyan Wang, Wenxia Zhao, Xiaoming Xi, Yang Li, Meilian Cai, Wuli Zhao, Yanni Xu, Rongguang Shao
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 147, Iss , Pp 112616- (2022)
Breast cancer (BC) is one of the most common malignant tumors in women globally, and its occurrence has surpassed lung cancer and become the biggest threat for women. At present, breast cancer treatment includes surgical resection or postoperative ch
Externí odkaz:
https://doaj.org/article/4bdd174840d84e998e3a6627c910f495
Autor:
Rui Cao, Wenping Song, Cheng Ye, Xiujun Liu, Liang Li, Yi Li, Hongjuan Yao, Xiaofei Zhou, Rongguang Shao
Publikováno v:
Cancer Medicine, Vol 8, Iss 2, Pp 643-655 (2019)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a refractory malignant tumor with poor prognosis, limited chemotherapeutic efficacy, and only about 5% of 5‐year survival rate. We generated a dual‐targeting ligand‐based lidamycin (DTLL) to i
Externí odkaz:
https://doaj.org/article/0519d5237e37447f86fc154baf994354