Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Rongan Zhang"'
Autor:
Ricardo A Garcia, Mujing Yan, Debra Search, Rongan Zhang, Nancy L Carson, Carol S Ryan, Constance Smith-Monroy, Joanna Zheng, Jian Chen, Yan Kong, Huaping Tang, Samuel E Hellings, Judith Wardwell-Swanson, Joseph E Dinchuk, George C Psaltis, David A Gordon, Peter W Glunz, Peter S Gargalovic
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111385 (2014)
BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lac
Externí odkaz:
https://doaj.org/article/226e843b35fe4bc7b87247e99442f01e
Autor:
Ricardo A García, Debra J Search, John A Lupisella, Jacek Ostrowski, Bo Guan, Jian Chen, Wen-Pin Yang, Amy Truong, Aiqing He, Rongan Zhang, Mujing Yan, Samuel E Hellings, Peter S Gargalovic, Carol S Ryan, Linda M Watson, Robert A Langish, Petia A Shipkova, Nancy L Carson, Joseph R Taylor, Richard Yang, George C Psaltis, Thomas W Harrity, Jeffrey A Robl, David A Gordon
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e53192 (2013)
BACKGROUND: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by
Externí odkaz:
https://doaj.org/article/6bd68584051f4497b56fefb3bbb8522c
Autor:
John Lupisella, Stéphane St-Onge, Marilyn Carrier, Erica M. Cook, Tao Wang, Chi Sum, Gayani Fernando, Kendra Apgar, Rongan Zhang, Nancy Carson, Bradley J. Snyder, Carol S. Ryan, Xiuying Ma, Elizabeth A. Dierks, Sean Little, Ellen K. Kick, Nicholas R. Wurtz, Michel Bouvier, Madeleine Héroux, Ricardo A. Garcia
Publikováno v:
ACS pharmacologytranslational science. 5(10)
Formyl peptide receptor 2 (FPR2) plays an integral role in the transition of macrophages from a pro-inflammatory program to one that is pro-resolving. FPR2-mediated stimulation of resolution post myocardial infarction has demonstrated efficacy in rod
Autor:
Claudia Generaux, Heather Finlay, Susan R. Arthur, Mei-Yin Hsu, Roy Haskell, Peter S. Gargalovic, Joelle M. Onorato, Michael Basso, Rongan Zhang, Kimberley A. Lentz, Anne Rose, Carrie Xu, Lei Zhao, Jeffrey S. Bostwick, Gayani Fernando, Ricardo Garcia, Xue-Qing Chen, James Hennan, Michael C. Myers, R. Michael Lawrence, Petia Shipkova, Samuel Hellings
Publikováno v:
Analytical Biochemistry. 568:41-50
Apelin, the endogenous ligand for the APJ receptor, has generated interest due to its beneficial effects on the cardiovascular system. Synthesized as a 77 amino acid preproprotein, apelin is post-translationally cleaved to a series of shorter peptide
Autor:
Moises Muratt Bustamante-Pozo, Rongan Zhang, Nancy L. Carson, Madeleine Héroux, Michel Bouvier, Jian Chen, David A. Gordon, Bruce R. Ito, Stéphane St.-Onge, Gayani Fernando, Marilyn Carrier, Francisco Villarreal, Zhaoqing Wang, Alejandra Garate-Carrillo, Carol S. Ryan, Jignesh Nagar, Jacek Ostrowski, John A. Lupisella, Ricardo Garcia, Shailesh Dudhgaonkar, Debra Search, Ellen K. Kick, Xiuying Ma, Ruth R. Wexler, Mei-Yin Hsu, Elizabeth A. Dierks, Nicholas R. Wurtz, John Allocco
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Autor:
Rongan Zhang, Gayani Fernando, Francisco Villarreal, Bruce R. Ito, Elizabeth A. Dierks, Nicholas R. Wurtz, Mei-Yin Hsu, Ricardo Garcia, John A. Lupisella, Y Kohno, Jacek Ostrowski, Carol S. Ryan, Nancy L. Carson, Zhaoqing Wang, Y Asahina
Publikováno v:
European Heart Journal. 40
Background/Introduction Dysregulated inflammation following myocardial infarction (MI) can lead to maladaptive infarct healing, myocardial damage and heart failure. Formyl peptide receptor 2 (FPR2) plays an important role in the ligand-dependent regu
Autor:
Joelle M, Onorato, Carrie, Xu, Xue-Qing, Chen, Anne V, Rose, Claudia, Generaux, Kimberley, Lentz, Petia, Shipkova, Susan, Arthur, James K, Hennan, Roy, Haskell, Michael C, Myers, R Michael, Lawrence, Heather J, Finlay, Michael, Basso, Jeffrey, Bostwick, Gayani, Fernando, Ricardo, Garcia, Samuel, Hellings, Mei-Yin, Hsu, Rongan, Zhang, Lei, Zhao, Peter, Gargalovic
Publikováno v:
Analytical biochemistry. 568
Apelin, the endogenous ligand for the APJ receptor, has generated interest due to its beneficial effects on the cardiovascular system. Synthesized as a 77 amino acid preproprotein, apelin is post-translationally cleaved to a series of shorter peptide
Autor:
Lisa Salvador, Richard Martin, Raju Mohan, Philip Wastall, Zhaoqing Wang, John A. Lupisella, Kamelia Behnia, Paul G. Sleph, Todd G. Kirchgessner, Petia Shipkova, Gayani Fernando, Jane Zhang, Carol S. Ryan, Rongan Zhang, Shuyan Du, Tong Li, Harold Malone, Ellen K. Kick, Glenn H. Cantor, Jun Zhu, Yu Chen Barrett, Jacek Ostrowski, Long Yuan, Denise Grimm, Aiqing He, John S. Lee, Robert J.A. Frost, Mohit D. Gandhi, Ricardo Garcia, Robert J. Garmise, Xiaoqin Liu
Publikováno v:
Cell Metabolism. 24:223-233
The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the effects of an LXR agonist on lipid and lipoprotein metabolism and neutrophils in human subje
Autor:
Doree F. Sitkoff, Ming Chang, Carolyn A Cuff, Bang-Chi Chen, Cort S. Madsen, Xiaohong Yin, Saleem Ahmad, Evan B. Janovitz, Richard A. Reeves, Thomas Harrity, Lawrence J. Kennedy, Carol S. Ryan, Hossain Monshizadegan, Van Nguyen-Tran, Tong Li, Robert Zahler, Michael A. Blanar, Khehyong Ngu, Philip D. Stein, Rongan Zhang, Sharon N. Bisaha, Christine Huang, Joel C. Barrish, Eileen Bird, Debra Search, Celia D’Arienzo, Mary Giancarli, Robert Setters, Rulin Zhao, Jeffrey A. Robl, Xing Chen, Shaobin Zhuang
Publikováno v:
Journal of Medicinal Chemistry. 51:2722-2733
3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating hypercholesterolemia. Although statins are regarded as generally safe, they are known to cause myopathy and, in
Autor:
Laurie Seliger, Jian Wang, Ronald Pongrac, Helen J. Mason, Bruce Beyer, Andrew Henwood, John Krupinski, Ximao Wu, John E. Macor, Saeho Chong, Rongan Zhang, Pam Ferrer, Diane E. Normandin, Guixue Yu, Leonard P. Adam, William G. Humphrey, Bin He
Publikováno v:
Journal of Medicinal Chemistry. 46:457-460
Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and selective PDE5 inhibitor than sildenafil (1). It is as efficacious as sildenafil in in vitro an