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Akademický článek

A-type EGCG dimer, a new proanthocyanidins dimer from persimmon fruits, interacts with the amino acid residues of Aβ40 which possessed high aggregation-propensity and strongly inhibits its amyloid fibrils formation

Autor: Rong-zu Nie, Mei-zhu Dang, Kai-kai Li, Jin-ming Peng, Jing Du, Meng-ying Zhang, Chun-mei Li

Publikováno v: Journal of Functional Foods, Vol 52, Iss , Pp 492-504 (2019)

A-type EGCG dimer is a new proanthocyanidins dimer from persimmon fruits. In the present study, we firstly examined the effects of EGCG and A-type EGCG dimer on Aβ40-fibrillization, and then the detailed mechanisms behind the inhibitory effects of p

Externí odkaz: https://doaj.org/article/9edd73895f724f86a2bd514019579a73

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Molecular insights into the inhibitory mechanisms of gallate moiety on the Aβ1–40 amyloid aggregation: A molecular dynamics simulation study

Autor: Yu Bo, Bao Honghui, Rui Zhou, Rong-zu Nie, Liu Chuanju, Tang Shangwen, Huo Yinqiang

Publikováno v: International Journal of Biological Macromolecules. 156:40-50

Alzheimer's disease is the most common form of neurodegenerative disease and the formation of Aβ amyloid aggregates has been widely demonstrated to be the principal cause of Alzheimer's disease. Our previous study and other studies suggested that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0ed4bb94b5b34e6036982d6084ca90
https://doi.org/10.1016/j.ijbiomac.2020.04.007

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Molecular insights into the very early steps of Aβ1-42 pentameric protofibril disassembly by PGG: A molecular dynamics simulation study

Autor: Rong-zu Nie, Shuang Cai, Bo Yu, Wen-ying Fan, Huan-huan Li, Shang-wen Tang, Yin-qiang Huo

Publikováno v: Journal of Molecular Liquids. 361:119638

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ff36039fd832a33a6730d6d678f7a79
https://doi.org/10.1016/j.molliq.2022.119638

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Influence of the gallate moiety on the interactions between green tea polyphenols and lipid membranes elucidated by molecular dynamics simulations

Autor: Yu Bo, Zhen-zhen Ge, Mei-zhu Dang, Huo Yinqiang, Rong-zu Nie, Tang Shangwen

Publikováno v: Biophysical chemistry. 274

Previous studies suggested that naturally occurring EGCG primarily acted on the bacterial cell membrane then damaged the membrane and the gallate moiety in EGCG was very important to its anti-bacterial activity. However, the detailed mechanisms were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f860a04c169cae13233f8f5fc5659374
https://pubmed.ncbi.nlm.nih.gov/33887572

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Molecular insights into the inhibitory mechanisms of gallate moiety on the Aβ

Autor: Rong-Zu, Nie, Yin-Qiang, Huo, Bo, Yu, Chuan-Ju, Liu, Rui, Zhou, Hong-Hui, Bao, Shang-Wen, Tang

Publikováno v: International journal of biological macromolecules. 156

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d0782c8ca85546482cde37d7621100e
https://pubmed.ncbi.nlm.nih.gov/32275992

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Interactions of chlorogenic acid and isochlorogenic acid A with model lipid bilayer membranes: Insights from molecular dynamics simulations

Autor: Zhen-zhen Ge, Mei-zhu Dang, Yu Bo, Tang Shangwen, Huo Yinqiang, Rong-zu Nie

Publikováno v: Chemistry and Physics of Lipids. 240:105136

Because of the negative side-effects of synthetic preservatives, the naturally-occurring polyphenols aroused intense interest of researchers. It has been suggested that chlorogenic acid (CA) and isochlorogenic acid A (iso-CAA) were good candidates to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18397deafd6dbf696d5da72dc757362b
https://doi.org/10.1016/j.chemphyslip.2021.105136

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