Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rong-Hong Zhang"'
Autor:
Yu-Chan Wang, Wen-Li Zhang, Rong-Hong Zhang, Chun-Hua Liu, Yong-Long Zhao, Guo-Yi Yan, Shang-Gao Liao, Yong-Jun Li, Meng Zhou
Publikováno v:
Molecules, Vol 28, Iss 24, p 8020 (2023)
As an important antiviral target, HIV-1 integrase plays a key role in the viral life cycle, and five integrase strand transfer inhibitors (INSTIs) have been approved for the treatment of HIV-1 infections so far. However, similar to other clinically u
Externí odkaz:
https://doaj.org/article/a18ade77fd9b4a40a49cb3dcbfef6aa6
Autor:
Yu-Chan Wang, Rong-Hong Zhang, Sheng-Cao Hu, Hong Zhang, Dan Yang, Wen-Li Zhang, Yong-Long Zhao, Dong-Bing Cui, Yong-Jun Li, Wei-Dong Pan, Shang-Gao Liao, Meng Zhou
Publikováno v:
Molecules, Vol 27, Iss 13, p 4040 (2022)
As a typical dibenzylisoquinoline alkaloid, tetrandrine (TET) is clinically used for the treatment of silicosis, inflammatory pulmonary, and cardiovascular diseases in China. Recent investigations have demonstrated the outstanding anticancer activity
Externí odkaz:
https://doaj.org/article/5cbc304a38dc42d48c5927a384947217
Autor:
Li-Juan Chen, Ai-Hua Peng, Jing-Xiang Qiu, Fei Peng, Guang-Cheng Wang, Jin-Ying Chen, Neng Qiu, Liang Ma, Shi-Chao He, Qin-Yuan Xu, Rong-Hong Zhang, Tao Chen
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6249-6268 (2012)
Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4,
Externí odkaz:
https://doaj.org/article/fd163b9f84554322941558af5bb7dd29
Autor:
Rong-Hong Zhang, Guo-Qi Chen, Weilin Wang, Yu-Chan Wang, Wen-Li Zhang, Ting Chen, Qian-Qian Xiong, Yong-Long Zhao, Shang-Gao Liao, Yong-Jun Li, Guo-Yi Yan, Meng Zhou
Publikováno v:
RSC Advances; 2024, Vol. 14 Issue 13, p9020-9031, 12p
Publikováno v:
Asian Journal of Organic Chemistry. 10:429-452
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f103a6a9141482e03c9a63e60daac55
https://doi.org/10.1002/ajoc.202000690
https://doi.org/10.1002/ajoc.202000690
Autor:
Rong-Hong, Zhang, Dan, Yang, Xiang-Ming, Liao, Hong, Zhang, Guo-Qi, Chen, Wen-Li, Zhang, Yu-Chan, Wang, Cong, Wang, Shang-Gao, Liao, Meng, Zhou, Yong-Lin, Wang, Yong-Jun, Li
Publikováno v:
European journal of medicinal chemistry. 238
As one of the most important features of myocardial ischemia reperfusion (MI/R) injury, the overproduction of reactive oxygen species (ROS) overwhelms the intrinsic antioxidant and impairs the function of mitochondria and, finally, leads to cardiomyo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59cd3f9025efd76eb0cb2cd2ea8edacd
https://pubmed.ncbi.nlm.nih.gov/35605360
https://pubmed.ncbi.nlm.nih.gov/35605360
Autor:
Dan Yang, Yongjun Li, Meng Zhou, Yong-Long Zhao, Yu-Chan Wang, Liao Xiangming, Hong Zhang, Liao Shanggao, Xu Guobo, Rong-Hong Zhang, Chun-Hua Liu
Publikováno v:
Journal of medicinal chemistry. 64(13)
Timely myocardial reperfusion salvages ischemic myocardium from infarction, whereas reperfusion itself induces cardiomyocyte death, which is called myocardial ischemia/reperfusion (MI/R) injury. Herein, β-carboline derivative 17c was designed and sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e421800a3b354c5234c94c67ad921c4c
https://pubmed.ncbi.nlm.nih.gov/34132541
https://pubmed.ncbi.nlm.nih.gov/34132541
Autor:
Dan Yang, Guoyi Yan, Wang Shan, Hong Zhang, Guo-Bo Xu, Yu-Chan Wang, Rong-Hong Zhang, Dong-Bing Cui, Guan Huanyu, Yong-Long Zhao, Yan-Hua Zhou, Yongjun Li, Meng Zhou, Shang-Gao Liao, Ting Liu
Publikováno v:
European journal of medicinal chemistry. 222
A series of 2,4-diamino pyrimidine (DAPY) derivatives were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymatic activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2310025d75fb7f33fe3109a03dcd33d5
https://pubmed.ncbi.nlm.nih.gov/34091209
https://pubmed.ncbi.nlm.nih.gov/34091209
Autor:
Guo-Bo Xu, Wang Lei, Meng Zhou, Yan-Hua Zhou, Wang Shan, Yong-Lin Wang, Yongjun Li, Shang-Gao Liao, Jie-Lin Liu, Hong Zhang, Yong-Long Zhao, Jun-Jie Lan, Wei-Dong Pan, Rong-Hong Zhang
Publikováno v:
Bioorganic chemistry. 101
Metastatic progression of cancer is a complex and clinically daunting process, with migration, invasion and angiogenesis being the key features. Tetrandrine (TET) is a typical dibenzylisoquinoline alkaloid with promising anti-tumor activity. In our p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16826341fabb278c8955529a5da7281
https://pubmed.ncbi.nlm.nih.gov/32599368
https://pubmed.ncbi.nlm.nih.gov/32599368
Autor:
Rong-Hong Zhang, Guoyi Yan, Shang-Gao Liao, Rong-Hua Luo, Guo-Bo Xu, Hong Zhang, Yong-Lin Wang, Yong-Tang Zheng, Wang Shan, Yong-Long Zhao, Yongjun Li, Rui Li, Meng Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126638
Viral infectivity factor (Vif) is one of the accessory protein of human immunodeficiency virus type I (HIV-1) that inhibits host defense factor, APOBEC3G (A3G), mediated viral cDNA hypermutations. Previous work developed a novel Vif inhibitor 2-amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da6754b6ea91adddbe359570630626e
https://doi.org/10.1016/j.bmcl.2019.126638
https://doi.org/10.1016/j.bmcl.2019.126638