Výsledky vyhledávání - "Rong Jian Liu"

Akademický článek

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Autor: Brendan D. Hare, Ryota Shinohara, Rong Jian Liu, Santosh Pothula, Ralph J. DiLeone, Ronald S. Duman

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.

Externí odkaz: https://doaj.org/article/2d3337a5795543eab74014329bf3aa23

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Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

Autor: Kyle Williams, Rong-Jian Liu, Christopher Pittenger, Susan E. Swedo, Shaylyn Fahey, Ronald S. Duman, Flora M. Vaccarino, Luciana Romina Frick, James F. Leckman, Jian Xu

Publikováno v: American Journal of Psychiatry. 178:48-64

Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation after i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edcaa72617a7c990d483f3878ac0ccd
https://doi.org/10.1176/appi.ajp.2020.19070698

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Cell-type specific modulation of NMDA receptors triggers antidepressant actions

Autor: Golam M. I. Chowdhury, Gerard Sanacora, Danielle M. Gerhard, Ronald S. Duman, Taro Kato, Rong-Jian Liu, Alexa-Nicole Sliby, Kevin L. Behar, Pradeep Banerjee, Ryota Shinohara, Santosh Pothula, Min Wu

Publikováno v: Molecular Psychiatry. 26:5097-5111

Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can exert rapid antidepressant effects as shown in several animal and human studies. However, how this bidirectional modulation of NMDARs causes similar antidepressan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e03e141cf0ebcc1b40db308e27626af8
https://doi.org/10.1038/s41380-020-0796-3

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Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation

Autor: Catharine H. Duman, Manoela V. Fogaça, Kenichi Fukumoto, Shigeyuki Chaki, Ronald S. Duman, Xiaoyuan Li, Rong-Jian Liu

Publikováno v: Neuropsychopharmacology. 45:1725-1734

We previously reported that the serotonergic system is important for the antidepressant-like effects of ketamine, a non-competitive N-methyl-D-aspartate receptor antagonist, which produces rapid and long-lasting antidepressant effects in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4bd7611f779fc3cc60b308750bc8587
https://doi.org/10.1038/s41386-020-0705-0

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N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects

Autor: Catharine H. Duman, Tina C. Franklin, Kenichi Fukumoto, Ronald S. Duman, Ottavio V. Vitolo, Manoela V. Fogaça, Rong-Jian Liu

Publikováno v: Neuropsychopharmacology

Currently available antidepressants have a delayed onset and limited efficacy, highlighting the need for new, rapid and more efficacious agents. Ketamine, an NMDA receptor antagonist, has emerged as a new rapid-acting antidepressant, effective even i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e449fc2728124b7e6fa5063da1b9da17
https://doi.org/10.1038/s41386-019-0501-x

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Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

Autor: Manoela V. Fogaça, Rong-Jian Liu, Xiaoyuan Li, Taro Kato, Ronald S. Duman, Catharine H. Duman, Kenichi Fukumoto

Publikováno v: Proceedings of the National Academy of Sciences. 116:297-302

Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces rapid and long-lasting antidepressant effects in major depressive disorder (MDD) patients. (2R,6R)-Hydroxynorketamine [(2R,6R)-HNK], a metabolite of ketamine, is rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc2989ec18e63caf43e9398ed870cff3
https://doi.org/10.1073/pnas.1814709116

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Cell-type specific modulation of NMDA receptors triggers antidepressant actions

Autor: Santosh, Pothula, Taro, Kato, Rong-Jian, Liu, Min, Wu, Danielle, Gerhard, Ryota, Shinohara, Alexa-Nicole, Sliby, Golam M I, Chowdhury, Kevin L, Behar, Gerard, Sanacora, Pradeep, Banerjee, Ronald S, Duman

Publikováno v: Molecular psychiatry. 26(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fe6635276122f6da576f3155583a994
https://pubmed.ncbi.nlm.nih.gov/32488125

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GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

Autor: Marina R. Picciotto, Catharine H. Duman, Santosh Pothula, Seth R. Taylor, Matthew J. Girgenti, Eric Delpire, Ronald S. Duman, Xiaoyuan Li, Min Wu, Eric S. Wohleb, Danielle M. Gerhard, Rong-Jian Liu

Publikováno v: J Clin Invest

A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f676378067e3cb563623decf3515c7e8
https://europepmc.org/articles/PMC7269589/

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Dopamine D2L Receptor Deficiency Alters Neuronal Excitability and Spine Formation in Mouse Striatum

Autor: Gubbi Govindaiah, Rong-Jian Liu, Yanyan Wang

Publikováno v: Biomedicines
Biomedicines; Volume 10; Issue 1; Pages: 101
Biomedicines, Vol 10, Iss 101, p 101 (2022)

The striatum contains several types of neurons including medium spiny projection neurons (MSNs), cholinergic interneurons (ChIs), and fast-spiking interneurons (FSIs). Modulating the activity of these neurons by the dopamine D2 receptor (D2R) can gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f76512c0e99ba360bb206dd409a8d59
https://doi.org/10.3390/biomedicines10010101

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