Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Rong Fong Shen"'
Autor:
Thomas G. Biel, Talia Faison, Alicia M. Matthews, Uriel Ortega‐Rodriguez, Vincent M. Falkowski, Edward Meek, Xin Bush, Matthew Flores, Sarah Johnson, Wells W. Wu, Mari Lehtimaki, Rong‐Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Janice E. Chambers, Tongzhong Ju
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 5, Pp n/a-n/a (2024)
Abstract Organophosphate (OP) toxicants remain an active threat to public health and to warfighters in the military. Current countermeasures require near immediate administration following OP exposure and are reported to have controversial efficacies
Externí odkaz:
https://doaj.org/article/47e008f8779e454493107a0ed1b19182
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Autor:
So Jin Bing, Sune Justesen, Wells W. Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 255-267 (2022)
Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle. Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of eff
Externí odkaz:
https://doaj.org/article/1b0e9853740c409c867ea3011ba44dc8
Autor:
Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, a
Externí odkaz:
https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
Autor:
Xiaoping Sun, Thomas Nguyen, Achouak Achour, Annette Ko, Jeffrey Cifello, Chen Ling, Jay Sharma, Toyoko Hiroi, Yongqing Zhang, Chee W. Chia, William Wood III, Wells W. Wu, Linda Zukley, Je-Nie Phue, Kevin G. Becker, Rong-Fong Shen, Luigi Ferrucci, Nan-ping Weng
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
A diverse T cell receptor (TCR) repertoire is essential for protection against a variety of pathogens, and TCR repertoire size is believed to decline with age. However, the precise size of human TCR repertoires, in both total and subsets of T cells,
Externí odkaz:
https://doaj.org/article/be9e3fbb629f4693b28c5ccd2679bf6e
Autor:
Mamatha Garige, Sarah Poncet, Alexis Norris, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Jacob W. Greenberg, Louis Spencer Krane, Carole Sourbier
Publikováno v:
Life, Vol 13, Iss 5, p 1196 (2023)
Opioids are commonly prescribed for extended periods of time to patients with advanced clear cell renal cell carcinoma to assist with pain management. Because extended opioid exposure has been shown to affect the vasculature and to be immunosuppressi
Externí odkaz:
https://doaj.org/article/f08346a3867445ad98755d9aec163075
Autor:
Mamatha Garige, Susmita Ghosh, Alexis Norris, Guangyuan Li, Sarah Poncet, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Carole Sourbier
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The immune checkpoint programmed death-ligand 1 (PD-L1) is expressed on the cell surface of tumor cells and is key for maintaining an immunosuppressive microenvironment through its interaction with the programmed death 1 (PD-1). Clear cell renal cell
Externí odkaz:
https://doaj.org/article/f478bab173b34a1bb08f1f2d8c0707c4
Autor:
Francesca Mascia, Ilya Mazo, Wei-Lun Alterovitz, Konstantinos Karagiannis, Wells W Wu, Rong-Fong Shen, Julia A Beaver, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262134 (2022)
Autophagy drives drug resistance and drug-induced cancer cell cytotoxicity. Targeting the autophagy process could greatly improve chemotherapy outcomes. The discovery of specific inhibitors or activators has been hindered by challenges with reliably
Externí odkaz:
https://doaj.org/article/f0155e8dbb3f4fd0956c34821514efd1
Autor:
Erica McGrath, Hyunsu Shin, Linyi Zhang, Je-Nie Phue, Wells W. Wu, Rong-Fong Shen, Yoon-Young Jang, Javier Revollo, Zhaohui Ye
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.
Externí odkaz:
https://doaj.org/article/af712862da014df4afe9e07f5f556c66
Autor:
Lai Xu, Helen Luo, Rong Wang, Wells W. Wu, Je-Nie Phue, Rong-Fong Shen, Hartmut Juhl, Leihong Wu, Wei-lun Alterovitz, Vahan Simonyan, Lorraine Pelosof, Amy S. Rosenberg
Publikováno v:
BMC Medical Genetics, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Reference genes are often interchangeably called housekeeping genes due to 1) the essential cellular functions their proteins provide and 2) their constitutive expression across a range of normal and pathophysiological conditions.
Externí odkaz:
https://doaj.org/article/4139dfba11ea48ae9b6493a2f0e9f38d