Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Ronen, Alon"'
Autor:
Anita Sapoznikov, Stav Kozlovski, Nehora Levi, Sara W. Feigelson, Ofer Regev, Natalia Davidzohn, Shifra Ben-Dor, Rebecca Haffner-Krausz, Ester Feldmesser, Noa Wigoda, Ekaterina Petrovich-Kopitman, Moshe Biton, Ronen Alon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112864- (2023)
Summary: Lymphocyte priming in lymph nodes (LNs) was postulated to depend on the formation of stable T cell receptor (TCR)-specific immune synapses (ISs) with antigen (Ag)-presenting dendritic cells (DCs). The high-affinity LFA-1 ligand ICAM-1 was im
Externí odkaz:
https://doaj.org/article/67139ba272364b81bc07233d20deeb03
Autor:
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
αLβ2 (LFA-1) mediated interactions with ICAM-1 and ICAM-2 predominate leukocyte-vascular interactions, but their functions in extravascular cell-cell communications is still debated. The roles of these two ligands in leukocyte trafficking, lymphocy
Externí odkaz:
https://doaj.org/article/42ff2249db14402eaf642c4f20e2336e
Autor:
Ofer Regev, Marina Kizner, Francesco Roncato, Maya Dadiani, Massimo Saini, Francesc Castro-Giner, Olga Yajuk, Stav Kozlovski, Nehora Levi, Yoseph Addadi, Ofra Golani, Shifra Ben-Dor, Zvi Granot, Nicola Aceto, Ronen Alon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Breast tumors and their derived circulating cancer cells express the leukocyte β2 integrin ligand Intercellular adhesion molecule 1 (ICAM-1). We found that elevated ICAM-1 expression in breast cancer cells results in a favorable outcome and prolonge
Externí odkaz:
https://doaj.org/article/d9e88f61fbda4bd2a272841d63826b3e
Publikováno v:
Cell Adhesion & Migration, Vol 15, Iss 1, Pp 166-179 (2021)
Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-st
Externí odkaz:
https://doaj.org/article/05da4d02cdf44c868b794f0b53c1568d
Autor:
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the authors show that LPS or Salmonella infection enhances glycolytic metabolism in bone marrow neutrophils, resulting in lactate production, which increas
Externí odkaz:
https://doaj.org/article/fd9905e2c6a74145a36f74cbae797fa7
Publikováno v:
Cell Adhesion & Migration, Vol 13, Iss 1, Pp 314-320 (2019)
It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturatin
Externí odkaz:
https://doaj.org/article/5cc387acedf745ec8c71bb10581837c8
Autor:
Panagiota Bouti, Steven D. S. Webbers, Susanna C. Fagerholm, Ronen Alon, Markus Moser, Hanke L. Matlung, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the innate immune response against invading bacterial and fungal pathogens, while recent emerging evidence also demonstrates their role in cancer progression
Externí odkaz:
https://doaj.org/article/572fb513c6ea41069fe1f4be174f5cf2
Autor:
Cristina Peligero-Cruz, Tal Givony, Arnau Sebé-Pedrós, Jan Dobeš, Noam Kadouri, Shir Nevo, Francesco Roncato, Ronen Alon, Yael Goldfarb, Jakub Abramson
Publikováno v:
eLife, Vol 9 (2020)
Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitu
Externí odkaz:
https://doaj.org/article/03a010dc029243e1bd1fd7afe17ebdb1
Autor:
Shirsendu Ghosh, Vincenzo Di Bartolo, Liron Tubul, Eyal Shimoni, Elena Kartvelishvily, Tali Dadosh, Sara W. Feigelson, Ronen Alon, Andres Alcover, Gilad Haran
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3434-3447.e6 (2020)
Summary: T cell surfaces are covered with microvilli, actin-rich and flexible protrusions. We use super-resolution microscopy to show that ≥90% of T cell receptor (TCR) complex molecules TCRαβ and TCRζ, as well as the co-receptor CD4 (cluster of
Externí odkaz:
https://doaj.org/article/f150b30a4f764bdbae634a217f5fa452
Autor:
Francesco Roncato, Fatlum Rruga, Elena Porcù, Elisabetta Casarin, Roberto Ronca, Federica Maccarinelli, Nicola Realdon, Giuseppe Basso, Ronen Alon, Giampietro Viola, Margherita Morpurgo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The nature of the linker is known to affect the efficacy of antibody–drug conjugate (ADC). Here the authors show cetuximab-guided Avidin-Nucleic-Acid-Nanoassemblies to be superior to cetuximab-doxorubicin conjugate, and show its efficacy in KRAS mu
Externí odkaz:
https://doaj.org/article/5b9f1af1b8e049f592c27421c329d673