Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ronda J. Ott"'
Autor:
Deborah A. Winegar, Peter J. Brown, William O. Wilkison, Michael C. Lewis, Ronda J. Ott, W.Q. Tong, H. Roger Brown, Jurgen M. Lehmann, Steven A. Kliewer, Kelli D. Plunket, James M. Way, Noni L. Bodkin, Barbara C. Hansen
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 10, Pp 1543-1551 (2001)
Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were developed primarily on the basis of their cholesterol and triglyceride lowering in rodents.
Externí odkaz:
https://doaj.org/article/e18df182ec9643e695a1b3b91bee8a1d
Autor:
Francis X. Tavares, Paul L. Feldman, Ronda J. Ott, Kamal A. Al-Barazanji, Huiqiang Zhou, Yu C. Guo, David L. Carlton, Daniel G. Lang, Michael J. Bishop, and Andrew J. Peat, Donald L. Hertzog, Mary K. Grizzle, Aaron S. Goetz, Anthony L. Handlon, Christy S. Britt, Eric C. Bigham, Diane M. Ignar
Publikováno v:
Journal of Medicinal Chemistry. 49:7095-7107
The high expression of MCH in the hypothalamus with the lean hypophagic phenotype coupled with increased resting metabolic rate and resistance to high fat diet-induced obesity of MCH KO mice has spurred considerable efforts to develop small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba88ed96984bac23ce99ed146435ec5d
https://doi.org/10.1021/jm060572f
https://doi.org/10.1021/jm060572f
Autor:
Daniel D. Sternbach, Timothy M. Willson, Peter Brown, Kevin G. Liu, William R. Oliver, Kelli D. Plunket, Ludwig William Stuart, Millard H. Lambert, Ronda J. Ott, Lisa M. Leesnitzer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2959-2962
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa2874766cc2849260d73caca173cc
https://doi.org/10.1016/s0960-894x(01)00596-0
https://doi.org/10.1016/s0960-894x(01)00596-0
Autor:
Ronda J. Ott, James M. Way, Deborah A. Winegar, Barbara C. Hansen, Noni L. Bodkin, Jürgen M. Lehmann, W.Q. Tong, Steven A. Kliewer, H. Roger Brown, Peter Brown, William O. Wilkison, Michael C. Lewis, Kelli D. Plunket
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 10, Pp 1543-1551 (2001)
Fenofibrate is a member of the fibrate class of hypolipidemic agents used clinically to treat hypertriglyceridemia and mixed hyperlipidemia. The fibrates were developed primarily on the basis of their cholesterol and triglyceride lowering in rodents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ba2dae4565af9cc6d0fa48d8a24c78
http://www.sciencedirect.com/science/article/pii/S0022227520322070
http://www.sciencedirect.com/science/article/pii/S0022227520322070
Autor:
Ronda J. Ott, Kathleen M. Giacomini
Publikováno v:
Pharmaceutical Research. 10:1169-1173
Recent studies have suggested that certain organic cations, such as pindolol and the diastereomers, quinine and quinidine, may be stereoselectively secreted by the kidney in humans. The goal of this study was to determine if the enantiomers of pindol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::286ef681618b6e05003e52d86c4ba982
https://doi.org/10.1023/a:1018968218573
https://doi.org/10.1023/a:1018968218573
Autor:
Ronda J. Ott, Kathleen M. Giacomini, Marcelo M. Gutierrez, Claire M. Brett, Carla B. Washington
Publikováno v:
Pharmaceutical Research. 10:423-426
The therapeutic efficacy of nucleosides and nucleoside analogues as antitumor, antiviral, antiparasitic, and antiarrhythmic agents has been well documented. Pharmacokinetic studies suggest that many of these compounds are actively transported in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c008a163906cddb96b47d151d8d599ec
https://doi.org/10.1023/a:1018948608211
https://doi.org/10.1023/a:1018948608211
Autor:
Daniel D. Sternbach, Peter Brown, Ronda J. Ott, Ludwig William Stuart, Millard H. Lambert, Kevin G. Liu, Kelli D. Plunket, Timothy M. Willson, Lisa M. Leesnitzer, William R. Oliver
Publikováno v:
ChemInform. 33
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91eee1c70f13ef6937324700e3417f05
https://doi.org/10.1002/chin.200208278
https://doi.org/10.1002/chin.200208278
Publikováno v:
Journal of Biological Chemistry. 267:133-139
Many organic cations are transported across the apical membrane of the proximal tubule by specific saturable mechanisms. The goal of this study was to determine if the transporter for tetraethylammonium (TEA) in the brush border membrane of an establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8868589e096a5fcbedeba3d4580598f
https://doi.org/10.1016/s0021-9258(18)48469-4
https://doi.org/10.1016/s0021-9258(18)48469-4
Publikováno v:
American Journal of Physiology-Renal Physiology. 261:F443-F451
The renal proximal tubule is responsible for the active elimination of organic cations. Studies in brush-border membrane vesicles (BBMV) suggest that active organic cation transport is mediated by an organic cation-proton antiporter. The goals of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300cdaf417ac4ecd8f76ff486c378707
https://doi.org/10.1152/ajprenal.1991.261.3.f443
https://doi.org/10.1152/ajprenal.1991.261.3.f443
Autor:
Rosanna C. Mirabile, Carie L. Kimbrough, Charles W. Qualls, Richard T. Miller, Zhiyang Zhao, Steven P. Anderson, H. Roger Brown, M. Santostefano, Heidi M. Colton, William B. Oliver, Debie J. Hoivik, Paul N. Mudd, Ray R. Dahl, Ronda J. Ott Morgan, Alan Robert Brown, Neal F. Cariello
Publikováno v:
Carcinogenesis. 25(9)
There is little primate risk factor data in the literature evaluating the relationship between proposed mechanisms of PPAR agonist-induced hepatocarcinogenesis at clinically relevant therapeutic exposures. These studies were conducted to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e34e87dcec63939943e3f639cf1160
https://pubmed.ncbi.nlm.nih.gov/15131011
https://pubmed.ncbi.nlm.nih.gov/15131011