Výsledky vyhledávání - "Ronda D. Schaadt"

In Vitro Activity of TR-700, the Active Ingredient of the Antibacterial Prodrug TR-701, a Novel Oxazolidinone Antibacterial Agent

Autor: Dean L. Shinabarger, Gary E. Zurenko, Ronda D. Schaadt, Debora Sweeney

Publikováno v: Antimicrobial Agents and Chemotherapy. 53:3236-3239

TR-701 is the prodrug of the microbiologically active molecule TR-700, a novel orally and intravenously administered oxazolidinone antibacterial agent. The in vitro activity of TR-700 was evaluated against 1,063 bacterial clinical isolates including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb327708465baf65e0153d37a1d9d3ea
https://doi.org/10.1128/aac.00228-09

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In Vitro Activity of TR-700, the Antibacterial Moiety of the Prodrug TR-701, against Linezolid-Resistant Strains

Autor: Vickie Brown-Driver, Dean L. Shinabarger, Karen Joy Shaw, Gary E. Zurenko, Chris M. Pillar, John T. Finn, S. Poppe, Ronda D. Schaadt

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:4442-4447

TR-701 is the orally active prodrug of TR-700, a novel oxazolidinone that demonstrates four- to eightfold-greater activity than linezolid (LZD) against Staphylococcus and Enterococcus spp. In this study evaluating the in vitro sensitivity of LZD-resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e80b4c184dadc7ae40e60a2568a351
https://doi.org/10.1128/aac.00859-08

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New Antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:4209-4212

Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2c3baddccd9423c1209ad56d9a34c7
https://doi.org/10.1016/j.bmcl.2003.07.022

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Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials

Autor: Betty H. Yagi, Judith C. Hamel, Judy K. Moerman, Ronda D. Schaadt, Gary E. Zurenko, Douglas Stapert, Paul Adrian Aristoff, Paul D. Johnson, Ford Charles W

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:4197-4200

Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f412553a393313c530f61f78d80adeb3
https://doi.org/10.1016/j.bmcl.2003.07.017

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Publikováno v: Journal of Medicinal Chemistry. 46:284-302

A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as important new therapeutic agents for the treatment of infections caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b367ff99342ae88e0043e780292f449
https://doi.org/10.1021/jm020248u

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Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Autor: Gary E. Zurenko, Betty H. Yagi, Douglas K Hutchinson, D E Emmert, David R. Graber, Jackson B. Hester, Stuart A. Garmon, Judith C. Hamel, Michael R Barbachyn, Ronda D. Schaadt, Michael J. Genin, Douglas Stapert, Joel Morris, David J. Anderson, Debra A. Allwine, R J Reischer, Charles W. Ford, Kevin C. Grega

Publikováno v: Journal of Medicinal Chemistry. 43:953-970

A series of new nitrogen-carbon-linked (azolylphenyl)oxazolidinone antibacterial agents has been prepared in an effort to expand the spectrum of activity of this class of antibiotics to include Gram-negative organisms. Pyrrole, pyrazole, imidazole, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5d651f8d650b464d8029599199ad82
https://doi.org/10.1021/jm990373e

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Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Potent Antibacterial Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

Autor: Charles W. Ford, Gary E. Zurenko, Hutchinson Douglas K, Betty H. Yagi, Janice M. Friis, D E Emmert, Michael J. Genin, Shobe Em, Jackson B. Hester, Stuart A. Garmon, Debra A. Allwine, Wade J. Adams, Ronda D. Schaadt, Judith C. Hamel, Douglas Stapert

Publikováno v: Journal of Medicinal Chemistry. 41:5144-5147

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ede7a71ce1717fa630e0f97cc748d9
https://doi.org/10.1021/jm980546k

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Ribosomes from an Oxazolidinone-Resistant Mutant Confer Resistance to Eperezolid in a Staphylococcus aureus Cell-Free Transcription-Translation Assay

Autor: Gary E. Zurenko, Ronda D. Schaadt, Robert W. Murray, Keith R. Marotti

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:947-950

Oxazolidinone-resistant mutants of Staphylococcus aureus , isolated with a spiral plating technique, had a 16-fold higher MIC (2 versus 32 μg/ml) of eperezolid when compared to the parental sensitive strain. Eperezolid inhibited in vitro protein tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bf19a4e13432c46f8c0e058c1119fc
https://doi.org/10.1128/aac.42.4.947

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