A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses.

Autor: Thimmiraju SR; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Adhikari R; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Redd JR; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Villar MJ; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Lee J; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Liu Z; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Chen YL; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Sharma S; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA., Kaur A; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Uzcategui NL; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Ronca SE; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA., Chen WH; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Kimata JT; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA., Zhan B; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Strych U; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA., Bottazzi ME; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Biology, Baylor University, Waco, TX, 76706, USA.; James A. Baker III Institute for Public Policy, Rice University, Houston, TX, 77005, USA., Hotez PJ; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.; Department of Biology, Baylor University, Waco, TX, 76706, USA.; James A. Baker III Institute for Public Policy, Rice University, Houston, TX, 77005, USA., Pollet J; Texas Children's Hospital Center for Vaccine Development, Houston, TX, 77030, USA. Jeroen.pollet@bcm.edu.; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, 77030, USA. Jeroen.pollet@bcm.edu.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA. Jeroen.pollet@bcm.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Jul 22; Vol. 9 (1), pp. 132. Date of Electronic Publication: 2024 Jul 22.

Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.

Autor: Bradley CC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Baylor College of Medicine Medical Scientist Training Program, Houston, TX, USA.; Robert and Janice McNair Foundation/ McNair Medical Institute M.D./Ph.D. Scholars program, Houston, TX, USA., Wang C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Gordon AJE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Wen AX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Baylor College of Medicine Medical Scientist Training Program, Houston, TX, USA.; Robert and Janice McNair Foundation/ McNair Medical Institute M.D./Ph.D. Scholars program, Houston, TX, USA., Luna PN; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Cooke MB; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Kohrn BF; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Kennedy SR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Avadhanula V; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA., Piedra PA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA., Lichtarge O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA., Shaw CA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ronca SE; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.; Feigin Biosafety Level 3 Facility, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Department of Pediatrics Tropical Medicine, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA., Herman C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA. herman@bcm.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 May; Vol. 9 (5), pp. 1382-1392. Date of Electronic Publication: 2024 Apr 22.

Immunogenicity phase II study evaluating booster capacity of nonadjuvanted AKS-452 SARS-Cov-2 RBD Fc vaccine.

Autor: Alleva DG; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Feitsma EA; Department of Surgery, University Medical Center Groningen (UMCG), Hanzeplein 1, 9700 RB, Groningen, The Netherlands., Janssen YF; Department of Nuclear Medicine and Molecular Imaging, UMCG, Groningen, The Netherlands., Boersma HH; Department of Nuclear Medicine and Molecular Imaging, UMCG, Groningen, The Netherlands.; Department of Clinical Pharmacy and Pharmacology, UMCG, Groningen, The Netherlands., Lancaster TM; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Sathiyaseelan T; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Murikipudi S; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Delpero AR; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Scully MM; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Ragupathy R; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Kotha S; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Haworth JR; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Shah NJ; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Rao V; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Nagre S; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA., Ronca SE; Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Baylor, College of Medicine, 1102 Bates Ave, 300.15, Houston, TX, 77030, USA., Green FM; Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Baylor, College of Medicine, 1102 Bates Ave, 300.15, Houston, TX, 77030, USA., Shaw SA; Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Baylor, College of Medicine, 1102 Bates Ave, 300.15, Houston, TX, 77030, USA., Aminetzah A; TRACER BV, Aarhusweg 2-1/2-2, 9723 JJ, Groningen, The Netherlands., Kruijff S; Department of Surgery, University Medical Center Groningen (UMCG), Hanzeplein 1, 9700 RB, Groningen, The Netherlands.; Department of Nuclear Medicine and Molecular Imaging, UMCG, Groningen, The Netherlands., Brom M; TRACER BV, Aarhusweg 2-1/2-2, 9723 JJ, Groningen, The Netherlands., van Dam GM; Department of Nuclear Medicine and Molecular Imaging, UMCG, Groningen, The Netherlands.; TRACER BV, Aarhusweg 2-1/2-2, 9723 JJ, Groningen, The Netherlands., Zion TC; Akston Biosciences Corporation, 100 Cummings Center, Suite 454C, Beverly, MA, 01915, USA. todd.zion@akstonbio.com.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Feb 21; Vol. 9 (1), pp. 40. Date of Electronic Publication: 2024 Feb 21.

Novel species of Triatoma (Hemiptera: Reduviidae) identified in a case of vectorial transmission of Chagas disease in northern Belize.

Autor: Gunter SM; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. Sm22@bcm.edu.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA. Sm22@bcm.edu.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA. Sm22@bcm.edu., Nelson A; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA., Kneubehl AR; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA., Justi SA; Walter Reed Biosystematics Unit, Smithsonian Institution, Museum Support Center, Suitland, MD, USA.; One Health Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.; Smithsonian Institution National Museum of Natural History, Washington, DC, USA., Manzanero R; Belize Ministry of Health and Wellness, Belmopan, Belize., Zielinski-Gutierrez E; Centers for Disease Control and Prevention-Central America Region, Guatemala City, Guatemala., Herrera C; Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Thompson J; Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.; Department of Biomedical Science, School of Medicine, Tulane University, New Orleans, LA, USA., Mandage R; Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Desale H; Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Maliga A; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA., Bautista K; Belize Ministry of Health and Wellness, Belmopan, Belize., Ronca SE; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA., Morey F; Belize Ministry of Health and Wellness, Belmopan, Belize., Fuentes RC; Centers for Disease Control and Prevention-Central America Region, Guatemala City, Guatemala., Lopez B; Centers for Disease Control and Prevention-Central America Region, Guatemala City, Guatemala., Dumonteil E; Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA., Morazan GH; Belize Ministry of Health and Wellness, Belmopan, Belize., Murray KO; Division of Tropical Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, USA.; National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, USA.

Publikováno v: Scientific reports [Sci Rep] 2024 Jan 16; Vol. 14 (1), pp. 1412. Date of Electronic Publication: 2024 Jan 16.

Early cellular and molecular signatures correlate with severity of West Nile virus infection.

Autor: Lee HJ; Department of Genetics and Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06520, USA., Zhao Y; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Fleming I; The Institute of Medical Science and Engineering, Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Mehta S; Department of Genetics and Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT 06520, USA., Wang X; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Wyk BV; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA., Ronca SE; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA., Kang H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chou CH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fatou B; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Smolen KK; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Levy O; Department of Infectious Disease, Precision Vaccines Program, Boston Children's Hospital, and Harvard Medical School, Boston, MA 02115, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Steen H; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA., Hafler DA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Love JC; The Institute of Medical Science and Engineering, Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Shalek AK; The Institute of Medical Science and Engineering, Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; The Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Guan L; Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA., Murray KO; Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, TX 77030, USA., Kleinstein SH; Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA., Montgomery RR; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

Publikováno v: IScience [iScience] 2023 Nov 02; Vol. 26 (12), pp. 108387. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2023).