Quantitative Measurement of Rate of Targeted Protein Degradation.

Autor: Lynch TL 4th; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Marin VL; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., McClure RA; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Phipps C; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Ronau JA; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Rouhimoghadam M; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Adams AM; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Kandi S; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Wolke ML; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Shergalis AG; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Potts GK; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Nacham O; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Richardson P; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Kakavas SJ; Target Enabling Technologies, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Chhor G; Target Enabling Technologies, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Jenkins GJ; Quantitative, Translational & ADME Sciences, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Woller KR; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Warder SE; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Vasudevan A; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States., Reitsma JM; Technology & Therapeutic Platforms, AbbVie Incorporated, 1 North Waukegan Rd., North Chicago, Illinois 60064, United States.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2024 Jul 19; Vol. 19 (7), pp. 1604-1615. Date of Electronic Publication: 2024 Jul 09.

A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi.

Autor: Berk JM; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA., Lim C; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA., Ronau JA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.; Discovery, Research and Development, AbbVie, Inc., North Chicago, IL, 60064, USA., Chaudhuri A; Department of Chemistry, Yale University, New Haven, CT, 06520, USA., Chen H; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA., Beckmann JF; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.; Department of Entomology and Plant Pathology, Auburn University, Auburn, AL, 36830, USA., Loria JP; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.; Department of Chemistry, Yale University, New Haven, CT, 06520, USA., Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA. yong.xiong@yale.edu., Hochstrasser M; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA. mark.hochstrasser@yale.edu.

Publikováno v: Nature communications [Nat Commun] 2020 May 11; Vol. 11 (1), pp. 2343. Date of Electronic Publication: 2020 May 11.

The DUB blade goes snicker-snack: Novel ubiquitin cleavage by a Legionella effector protein.

Autor: Ronau JA; Departments of Molecular Biophysics &Biochemistry., Hochstrasser M; Departments of Molecular Biophysics &Biochemistry.; Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.

Publikováno v: Cell research [Cell Res] 2017 Jul; Vol. 27 (7), pp. 845-846. Date of Electronic Publication: 2017 Jun 02.

Substrate specificity of the ubiquitin and Ubl proteases.

Autor: Ronau JA; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA., Beckmann JF; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA., Hochstrasser M; Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.; Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.

Publikováno v: Cell research [Cell Res] 2016 Apr; Vol. 26 (4), pp. 441-56. Date of Electronic Publication: 2016 Mar 25.

A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis.

Autor: Ronau JA; Department of Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States., Paul LN, Fuchs JE, Liedl KR, Abu-Omar MM, Das C

Publikováno v: Biochemistry [Biochemistry] 2014 Nov 04; Vol. 53 (43), pp. 6834-48. Date of Electronic Publication: 2014 Oct 23.