Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria

Autor: Wirongrong Chierakul, Sornchai Looareesuwan, Cyril Mounier, Nicholas J. White, Arjen M. Dondorp, Alan Brockman, Jean-François Chaulet, Paul N. Newton, Ronatrai Ruangveerayuth

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ebfe89774518fb56a2741ed40138da
https://doi.org/10.1128/aac.49.4.1622-1625.2005

Prognostic significance of reduced red blood cell deformability in severe falciparum malaria

Autor: Adrianus M. Dondorp, Piet A. Kager, Ronatrai Ruangveerayuth, Nicholas J. White, Max R. Hardeman, Kesinee Chotivanich, Brian Angus, Kamdrat Silamut, J Vreeken

Publikováno v: Scopus-Elsevier
American journal of tropical medicine and hygiene, 57(5), 507-511. American Society of Tropical Medicine and Hygiene

Severe falciparum malaria is associated with microvascular obstruction resulting from sequestration of erythrocytes containing mature stages of the parasite. Since reduced red blood cell deformability (RBC-D) can contribute to impaired microcirculato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8069e5f0ea0569b171416f03c11394
https://ora.ox.ac.uk/objects/uuid:b478838a-ced7-4953-b63e-6669b59d3184

Randomized Comparison of Artesunate and Quinine in the Treatment of Severe Falciparum Malaria

Autor: Sornchai Looareesuwan, Yupin Suputtamongkol, Brian Angus, Arjen M. Dondorp, Pramote Teerapong, Wirongrong Chierakul, Paul N. Newton, Ronatrai Ruangveerayuth, Kamolrat Silamut, Nicholas J. White

Publikováno v: Clinical Infectious Diseases. 37:7-16

A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria in western Thailand. Mortality was 12% with artesunate and 22% with quinine treatment (relative risk, 0.53; 95% confid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0171748a498a675337d52ce4d2e9ec8f
https://doi.org/10.1086/375059

The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria

Autor: Alicia Evans, Nicholas J. White, Karen I. Barnes, Wirongrong Chierakul, Pete Smith, Paul N. Newton, Ronatrai Ruangveerayuth

Publikováno v: European journal of clinical pharmacology. 62(12)

OBJECTIVE: Intravenous artesunate is commonly used in the emergency treatment of patients with severe falciparum malaria in Asia. The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intrav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf151cc11db5bbcb04598d13b345be38
https://pubmed.ncbi.nlm.nih.gov/17089111

A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes

Autor: Sornchai Looareesuwan, Kesinee Chotivanich, Kamolrat Silamut, Paul N. Newton, Wirongrong Chierakul, Nicholas J. White, Pramote Teerapong, Ronatrai Ruangveerayuth

Publikováno v: Blood. 98(2)

Ring-infected erythrocyte surface antigen (RESA)-positive,Plasmodium falciparum–negative red blood cells (RBCs) are cells from which the malaria parasite has been removed by the host without the destruction of the erythrocyte (“pitting”). The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca70bd74b3abd4e6dbdc8f4a8d7c1d3f
http://ora.ox.ac.uk/objects/uuid:badf1aac-69cd-4b88-8225-c479f68cf871