Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ronan P. Kelly"'
Autor:
Harshabad Singh, Kristen E. Lowder, Kevin Kapner, Ronan J. Kelly, Hui Zheng, Nadine Jackson McCleary, Thomas A. Abrams, Jennifer A. Chan, Eileen M. Regan, Samuel J. Klempner, Alison M. Hannigan, Joshua Remland, Lauren K. Brais, Elizabeth Andrews, Matthew Yurgelun, James M. Cleary, Douglas A. Rubinson, Lauren L. Ritterhouse, Garrett Maron, Andrew J. Aguirre, Jeffrey A. Meyerhardt, Emma Gardecki, Jochen K. Lennerz, Brian M. Wolpin, Peter C. Enzinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Preclinical studies suggest that simultaneous HER2/VEGF blockade may have cooperative effects in gastroesophageal adenocarcinomas. In a single-arm investigator initiated clinical trial for patients with untreated advanced HER2+ gastroesophag
Externí odkaz:
https://doaj.org/article/df43da4c105c4a28ae7e276e1e916753
Autor:
Hirsch Matani, Divya Sahu, Michael Paskewicz, Anastasia Gorbunova, Ashten N. Omstead, Rodney Wegner, Gene G. Finley, Blair A. Jobe, Ronan J. Kelly, Ali H. Zaidi, Ajay Goel
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-10 (2022)
Abstract Background Esophageal adenocarcinoma is a lethal disease. For locally advanced patients, neoadjuvant chemoradiotherapy followed by surgery is the standard of care. Risk stratification relies heavily on clinicopathologic features, particularl
Externí odkaz:
https://doaj.org/article/178cde6cc10e4888acb8aff864a4df0f
Autor:
Lipika Goyal, Smitha Krishnamurthi, Dung T Le, Ronan J Kelly, Cathy Eng, Geoffrey Ku, Manish A Shah, Marwan Fakih, Joseph Chao, Van K Morris, Katherine Bever, Kristen K Ciombor, Joleen Hubbard, Renuka Iyer, Holly T Kemberling, Mindy Mintz Mordecai, Andrew Scott Paulson, Valerie Peterson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Gastrointestinal (GI) cancers, including esophageal, gastroesophageal junction, gastric, duodenal and distal small bowel, biliary tract, pancreatic, colon, rectal, and anal cancer, comprise a heterogeneous group of malignancies that impose a signific
Externí odkaz:
https://doaj.org/article/ebebf3bf4cc94f57adb8f23cda6cee23
Publikováno v:
Cancers, Vol 15, Iss 22, p 5401 (2023)
Background: Gastroesophageal cancers (GECs) carry considerable morbidity and mortality, and demonstrate geographical histological variances in addition to molecular heterogeneity. Consequently, the immunogenicity of the different subtypes, which can
Externí odkaz:
https://doaj.org/article/fdafec2a1f5f408db2df9ed1704e9d82
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
Abstract Background The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cel
Externí odkaz:
https://doaj.org/article/2c0f82402ee7444596300a1ca0795729
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Michael Lloyd, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss , Pp 49-56 (2021)
Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity
Externí odkaz:
https://doaj.org/article/577b1f6cdaaf44fe9f8ca25ad5e49c52
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 102 (2023)
In the West, recent decades have demonstrated an epidemiological trend towards esophago-gastric adenocarcinomas (EGAC), with considerable associated mortality. Historically, chemotherapy has represented the sole systemic treatment option in the advan
Externí odkaz:
https://doaj.org/article/587fa148a1a94b66871606014f9f588c
Autor:
Douglas W. Blayney, Nafisa Albdelhafeez, Abdul Rahman Jazieh, Carlos Frederico Pinto, Adrian Udrea, Alex Roach, Devika Das, Stephen Grubbs, John Hamm, Mohammad Jahanzeb, Arif H. Kamal, Ronan J. Kelly, S. Eric Martin, Deirdre O'Mahony, Walter Birch, Ronda Bowman, Stéphanie T. S. Crist, Amy Evers, Terry Gilmore, Meredith Klein, Robert Siegel
Publikováno v:
JCO Global Oncology, Vol , Iss 6, Pp 697-703 (2020)
Externí odkaz:
https://doaj.org/article/689d6c41e9d641f3a470e74d824019e4
Autor:
Cindy Ke Zhou, Monica M Bennett, Carlos H Villa, Kendall P Hammonds, Yun Lu, Jason Ettlinger, Elisa L Priest, Robert L Gottlieb, Steven Davis, Edward Mays, Tainya C Clarke, Azadeh Shoaibi, Hui-Lee Wong, Steven A Anderson, Ronan J Kelly
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273223 (2022)
BackgroundAlthough frequently used in the early pandemic, data on the effectiveness of COVID-19 convalescent plasma (CCP) remain mixed. We investigated the effectiveness and safety of CCP in hospitalized COVID-19 patients in real-world practices duri
Externí odkaz:
https://doaj.org/article/718fc3f33d8149c7b8b0c341f2a5110c
Autor:
Adrian Murphy, Ronan J. Kelly
Publikováno v:
Gastroenterology Research and Practice, Vol 2015 (2015)
Histological classification of adenocarcinoma or squamous cell carcinoma for esophageal cancer or using the Lauren classification for intestinal and diffuse type gastric cancer has limited clinical utility in the management of advanced disease. Germl
Externí odkaz:
https://doaj.org/article/5921fc7c4e214f8d8d3a44b6fd3dfe4e