Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ronan P Hanley"'
Autor:
Ronan P. Hanley, David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K. Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M. Szewczyk, Peter J. Brown, Dalia Barsyte-Lovejoy, Laura E. Herring, Gang Greg Wang, Jonathan D. Licht, Masoud Vedadi, Cheryl H. Arrowsmith, Lindsey I. James
Publikováno v:
Journal of the American Chemical Society. 145:8176-8188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95bc98e1fc4dc9f993866f26284bf64e
https://doi.org/10.1021/jacs.3c01421
https://doi.org/10.1021/jacs.3c01421
Autor:
Frances M. Bashore, Caroline A. Foley, Han Wee Ong, Justin M. Rectenwald, Ronan P. Hanley, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Christine A. Mills, Kenneth H. Pearce, Laura E. Herring, Dmitri Kireev, Stephen V. Frye, Lindsey I. James
Publikováno v:
ACS Chemical Biology. 18:494-507
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f07a145587e308b683ae0e8ff599158
https://doi.org/10.1021/acschembio.2c00804
https://doi.org/10.1021/acschembio.2c00804
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29b52d0f1e30e6d3bd73de3c2a5989b
https://doi.org/10.1038/s41589-021-00898-0
https://doi.org/10.1038/s41589-021-00898-0
Autor:
Derek J Blevins, Fraser Hof, Trevor Bolduc, David A. Powell, Ronan P. Hanley, Michael C. Gignac, Mark D. Carr, Jeremy E. Wulff, Kayleigh Walker
Publikováno v:
ACS Med Chem Lett
[Image: see text] The programmed cell death protein 1 (PD-1) signaling axis is among the most important therapeutic targets in modern oncology. Aurigene Discovery Technologies Ltd. (Aurigene) has patented a series of peptidomimetic small molecules de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb19ca7dea14ef35a8bba6bb8d93313
https://doi.org/10.1021/acsmedchemlett.9b00221
https://doi.org/10.1021/acsmedchemlett.9b00221
Autor:
Jinrong Min, Matthew R. Marunde, Dmitri Kireev, Jack Greenblatt, Ferreira de Freitas R, Tigran M. Abramyan, Cheryl H. Arrowsmith, Peter Brown, Magda Szewczyk, Irene Chau, A. Dong, Kazemzadeh S, Dalia Barsyte-Lovejoy, Ronan P Hanley, Mengqi Zhou, Y. Liu, Michael-Christopher Keogh, Lindsey I. James, Edyta Marcon, Matthieu Schapira, David Dilworth, Ming Lei, Popova Ik, Albina Bolotokova, Marcus A. Cheek, Masoud Vedadi, Elisa Gibson, Suzanne Ackloo, Su Qin, Matthew J. Meiners, Nathan W. Hall, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two PWWP and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c6ef23b32f1b09d83b9d0588c0ec9
https://doi.org/10.1101/2021.03.05.433782
https://doi.org/10.1101/2021.03.05.433782
Autor:
Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Jinrong Min, Ronan P Hanley, Rima Al-awar, Matthieu Schapira, Lindsey I. James, Renato Ferreira de Freitas, Magdalena M. Szewczyk, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li, Carlos Zepeda-Velázquez, Elisa Gibson, David McLeod, Yanli Liu, Peter Brown, David Dilworth
Publikováno v:
J Med Chem
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date. Here, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8b7c6e44c401bcb2e89319bec3ca4f
https://pubmed.ncbi.nlm.nih.gov/33522809
https://pubmed.ncbi.nlm.nih.gov/33522809
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:973-977
Given the importance of high-throughput screening in drug discovery, the identification of compounds that interfere with assay readouts is crucial. The pursuit of false positives wastes time and money, while distracting development teams from more pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beba8e1b7986719cb58b284f9415a38f
https://doi.org/10.1016/j.bmcl.2015.12.050
https://doi.org/10.1016/j.bmcl.2015.12.050
Autor:
Ronan P. Hanley, Natasha F. O’Rourke, Anna R. Patten, Brian R. Christie, Ana Lúcia S. Rodrigues, Jeremy E. Wulff, Karthik Gopalakrishnan, Luis E.B. Bettio, Samantha Kennedy, Joana Gil-Mohapel
Publikováno v:
Neuroscience. 332
Adult hippocampal neurogenesis can be modulated by various physiological and pathological conditions, including stress, affective disorders, and several neurological conditions. Given the proposed role of this form of structural plasticity in the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0ceb042564ae9aa7b64c5b0a0f53f2
https://pubmed.ncbi.nlm.nih.gov/27373772
https://pubmed.ncbi.nlm.nih.gov/27373772