Complete Protection against Influenza Virus H1N1 Strain A/PR/8/34 Challenge in Mice Immunized with Non-Adjuvanted Novirhabdovirus Vaccines.

Autor: Ronan N Rouxel, Emilie Mérour, Stéphane Biacchesi, Michel Brémont

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164245 (2016)

Novirhabdoviruses like Viral Hemorrhagic Septicemia Virus (VHSV) and Infectious Hematopoietic Necrosis Virus (IHNV) are fish-infecting Rhabdoviruses belonging to the Mononegavirales order. By reverse genetics, we previously showed that a recombinant

Externí odkaz: https://doaj.org/article/7d0a2adf5c8c44b7a2c8d0b8c1daa58e

Chimeric Hemagglutinin-Based Influenza Virus Vaccines Induce Protective Stalk-Specific Humoral Immunity and Cellular Responses in Mice

Autor: Badiaa Bouzya, Klaus-Daniel Cortés Franco, Marie Van der Wielen, Ronan N. Rouxel, Roland Mainil, Florian Krammer, Arvind Rajabhathor, Bruce L. Innis, Peter Palese, Michael Schotsaert, Corey P. Mallett, Raffael Nachbagauer, Daniel Stadlbauer, Angela Choi, Adolfo García-Sastre

Publikováno v: ImmunoHorizons. 3(4)

The high variation of the influenza virus hemagglutinin (HA), particularly of its immunodominant head epitopes, makes it necessary to reformulate seasonal influenza virus vaccines every year. Novel influenza virus vaccines that redirect the immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d505a1027caad5ceb14e885ccd198f8
https://pubmed.ncbi.nlm.nih.gov/31032479

Chimeric hemagglutinin supra-seasonal universal influenza vaccine candidates administered sequentially by the intramuscular route are locally and systemically well-tolerated in rabbits

Autor: Catherine Thirion-Delalande, Corey P. Mallett, Badiaa Bouzya, Ronan N. Rouxel, Eric Destexhe, Emilie Grosdidier, Adèle Bouhraoua, Judith Baumeister

Publikováno v: Regulatory Toxicology and Pharmacology. 113:104625

Sequential intramuscular immunization with chimeric hemagglutinins (cHA) composed of the same conserved HA stalk domain and distinct HA heads is a proposed strategy to produce a supra-seasonal universal influenza vaccine. To evaluate the local tolera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d7c69819fd8fdca29997cb531c1731
https://doi.org/10.1016/j.yrtph.2020.104625

Attenuated infectious hematopoietic necrosis virus with rearranged gene order as potential vaccine

Autor: Ronan N. Rouxel, Stéphane Biacchesi, Carolina Tafalla, Michel Brémont, Emilie Mérour, Esther Leal

Publikováno v: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
Journal of Virology
Journal of Virology, American Society for Microbiology, 2016, 90 (23), pp.10857-10866. ⟨10.1128/JVI.01024-16⟩
Journal of Virology 23 (90), 10857-10866. (2016)
INIA: Repositorio de Resultados de Investigación del INIA

The genome of infectious hematopoietic necrosis virus (IHNV), a salmonid novirhabdovirus, has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo . By reverse genetics, eight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2fea75b7bb1b487ee5c1e44e1569ef

A chimeric measles virus with canine distemper envelope protects ferrets from lethal distemper challenge

Autor: Nicholas Svitek, Veronika von Messling, Ronan N. Rouxel

Publikováno v: Vaccine. 27:4961-4966

CDV infects a broad range of carnivores, and over the past decades it has caused outbreaks in a variety of wild carnivore populations. Since the currently available live-attenuated vaccine is not sufficiently safe in these highly susceptible species,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11e4faec5408de90a7732048cd3f0bc
https://doi.org/10.1016/j.vaccine.2009.05.096