Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ronan M.T. Fleming"'
Autor:
Ines Thiele, Ronan M.T. Fleming
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4098-4109 (2022)
We aimed at investigating host-virus co-metabolism during SARS-CoV-2 infection. Therefore, we extended comprehensive sex-specific, whole-body organ resolved models of human metabolism with the necessary reactions to replicate SARS-CoV-2 in the lung a
Externí odkaz:
https://doaj.org/article/5994886de1c7473ab425026880569dd0
Autor:
Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1144-1154 (2017)
Research on human brain development and neurological diseases is limited by the lack of advanced experimental in vitro models that truly recapitulate the complexity of the human brain. Here, we describe a robust human brain organoid system that is hi
Externí odkaz:
https://doaj.org/article/1f250250cc794665b371c2344ef28541
Autor:
Johannes Hertel, Amy C. Harms, Almut Heinken, Federico Baldini, Cyrille C. Thinnes, Enrico Glaab, Daniel A. Vasco, Maik Pietzner, Isobel D. Stewart, Nicholas J. Wareham, Claudia Langenberg, Claudia Trenkwalder, Rejko Krüger, Thomas Hankemeier, Ronan M.T. Fleming, Brit Mollenhauer, Ines Thiele
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1767-1777.e8 (2019)
Summary: Parkinson’s disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched controls with co
Externí odkaz:
https://doaj.org/article/5e5f0680757b4363b9d61648d5f1837f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 484-491 (2015)
One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical
Externí odkaz:
https://doaj.org/article/80f6f0fc2cc045cbbfd1488d0bc05c29
Autor:
German Preciat, Agnieszka B. Wegrzyn, Edinson Lucumi Moreno, Cornelius C.W. Willacey, Jennifer Modamio, Fatima L. Monteiro, Diana El Assal, Alissa Schurink, Miguel A.P. Oliveira, Zhi Zhang, Ben Cousins, Hulda S. Haraldsdóttir, Siham Hachi, Susanne Zach, German Leparc, Yin Tat Lee, Bastian Hengerer, Santosh Vempala, Michael A. Saunders, Amy Harms, Enrico Glaab, Jens C. Schwamborn, Ines Thiele, Thomas Hankemeier, Ronan M.T. Fleming
Patient-derived cellular models are a powerful approach to study human disease, especially neurode-generative diseases, such as Parkinson’s disease, where affected primary neurons, e.g., substantia nigra dopaminergic neurons, are almost inaccessibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bcc67eaf5b3fd1d397e56bcd6b6b301
https://doi.org/10.1101/2021.06.30.450562
https://doi.org/10.1101/2021.06.30.450562
