Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ronan M. Kelly"'
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
Abstract Background The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cel
Externí odkaz:
https://doaj.org/article/2c0f82402ee7444596300a1ca0795729
Autor:
Laura Bryan, Michael Henry, Ronan M. Kelly, Michael Lloyd, Christopher C. Frye, Matthew D. Osborne, Martin Clynes, Paula Meleady
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss , Pp 49-56 (2021)
Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity
Externí odkaz:
https://doaj.org/article/577b1f6cdaaf44fe9f8ca25ad5e49c52
Publikováno v:
Protein Expression and Purification. 207:106269
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2305501f484f8e6edc2d54025c9daf1e
https://doi.org/10.1016/j.pep.2023.106269
https://doi.org/10.1016/j.pep.2023.106269
Autor:
Matthew D. Osborne, Ronan M. Kelly, Martin Clynes, Christopher C. Frye, Michael Henry, Michael E. Lloyd, Laura Bryan, Paula Meleady
Publikováno v:
Current Research in Biotechnology, Vol 3, Iss, Pp 49-56 (2021)
Understanding the biology of CHO cells at a cellular level is extremely valuable to the pharmaceutical industry, as it presents the opportunity to rationally engineer clonally derived cell lines (CDCLs) with elevated recombinant specific productivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c79b82f1d7683b96a0f04fa4574d724
http://www.sciencedirect.com/science/article/pii/S259026282100006X
http://www.sciencedirect.com/science/article/pii/S259026282100006X
Autor:
Michael Henry, Laura Bryan, Matthew D. Osborne, Ronan M. Kelly, Christopher C. Frye, Paula Meleady, Martin Clynes
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
BMC Biotechnology, Vol 21, Iss 1, Pp 1-21 (2021)
Background The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant protein yields, reduce host cell impurit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94ee106dba105b6e839b2d08b4e6f8e
https://doi.org/10.1186/s12896-021-00704-8
https://doi.org/10.1186/s12896-021-00704-8
Autor:
Michael Henry, Paula Meleady, Niall Barron, Clair Gallagher, Martin Clynes, Laura Bryan, Christopher C. Frye, Matthew D. Osborne, Ronan M. Kelly
Publikováno v:
Biotechnology Letters
Objectives We used miRNA and proteomic profiling to understand intracellular pathways that contribute to high and low specific productivity (Qp) phenotypes in CHO clonally derived cell lines (CDCLs) from the same cell line generation project. Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393fa236acf55412bafece999beefcca
https://pubmed.ncbi.nlm.nih.gov/34131805
https://pubmed.ncbi.nlm.nih.gov/34131805
Autor:
Michael Henry, Paula Meleady, Martin Clynes, Christopher C. Frye, Ciaran P. Brady, Niall Barron, Clair Gallagher, Ronan M. Kelly, Matthew D. Osborne
Publikováno v:
Journal of Biotechnology. 281:21-30
Product degradation, such as clipping, is a common quality issue in the production of Fc-fusion proteins from Chinese hamster ovary (CHO) cells. Degradation of proteins is mainly due to the action of either intracellular or extracellular host cell pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d11043883c87492e496e6a45bc4006d
https://doi.org/10.1016/j.jbiotec.2018.05.018
https://doi.org/10.1016/j.jbiotec.2018.05.018
Publikováno v:
Current opinion in biotechnology. 53
Biopharmaceuticals such as monoclonal antibodies have revolutionised the treatment of a variety of diseases. The production of recombinant therapeutic proteins, however, remains expensive due to the manufacturing complexity of mammalian expression sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a28ad2402c4469af0d2adefdefe83b3
https://pubmed.ncbi.nlm.nih.gov/29471208
https://pubmed.ncbi.nlm.nih.gov/29471208
Autor:
Beth A. Strifler, Derrick R. Witcher, Christopher C. Frye, Ronald L. Kowle, Zhirui Lian, Ronan M. Kelly, Tongtong Wang, Bhavin S. Parekh
Publikováno v:
Biotechnology and bioengineering. 115(3)
Cross-linking of the Fcγ receptors expressed on the surface of hematopoietic cells by IgG immune complexes triggers the activation of key immune effector mechanisms, including antibody-dependent cell mediated cytotoxicity (ADCC). A conserved N-glyca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2b93382bb9262a7ce0858d21e8bbbb
https://pubmed.ncbi.nlm.nih.gov/29150961
https://pubmed.ncbi.nlm.nih.gov/29150961
Autor:
Ákos Szekrényes, Niclas G. Karlsson, András Guttman, Ronan M. Kelly, Barbara Adamczyk, Pauline M. Rudd, Michael Schomberg, Tharmala Tharmalingam-Jaikaran
Publikováno v:
Carbohydrate Research
Carbohydrate Research; Vol 389
Carbohydrate Research; Vol 389
The IgG N-glycome provides sufficient complexity and information content to serve as an excellent source for biomarker discovery in mammalian health. Since oligosaccharides play a significant role in many biological processes it is very important to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebedc48430a0fb6915af44364b618aa