Výsledky vyhledávání - "Ronan J. Walsh"

Clinical findings in MuSK-antibody positive myasthenia gravis: A U.S. experience

Publikováno v: Muscle & Nerve. 41:370-374

We performed a retrospective chart review on 53 muscle-specific kinase antibody (MuSK-Ab)-positive myasthenia gravis (MG) patients at nine university-based centers in the U.S. Of these, 66% were Caucasian, 85% were women, and age of onset was 9-79 ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4a360c71e80edd241354ed81937b10
https://doi.org/10.1002/mus.21533

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Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy

Autor: Jack L. Pinkus, Ronan J. Walsh, Anthony A. Amato, Brandon W. Higgs, Steven A. Greenberg, Mohammad Salajegheh, Bryan Krastins, Remedios Nazareno, Chris Morehouse, Sek Won Kong, David A. Sarracino, Yihong Yao, Bahija Jallal, Anne Liao, Kenneth C. Parker

Publikováno v: Annals of Neurology. 67:53-63

Dermatomyositis (DM) is an autoimmune disease of unknown cause primarily affecting skeletal muscle and skin. The characteristic muscle pathology of DM is notable for capillary abnormalities and small, abnormal appearing muscle fibers around the perip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbe4292823119e49294fa3d05c7eab9
https://doi.org/10.1002/ana.21805

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Characterization of Human Skeletal Muscle Biopsy Samples Using Shotgun Proteomics

Autor: David A. Sarracino, Ronan J. Walsh, Mohammad Salajegheh, Steven A. Greenberg, Anthony A. Amato, Bryan Krastins, Kenneth C. Parker

Publikováno v: Journal of Proteome Research. 8:3265-3277

We characterized the human muscle proteome by studying muscle biopsy specimens through four different workflows, using 1 or 2D peptide separation, SDS gels, or differential solubilization. By performing MS/MS analyses of 178 4-h LC separations derive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d21b9df9d4b9b35cb1af47479bd688
https://doi.org/10.1021/pr800873q

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Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO-029

Autor: Lisa S. Krivickas, Ronan J. Walsh, Anthony A. Amato

Publikováno v: Muscle & Nerve. 39:3-9

Myostatin inhibitors are being investigated as treatments for myopathies. We assessed single muscle fiber contractile properties before and after 6 months of study drug in 6 patients with facioscapulohumeral, Becker, and limb-girdle muscular dystroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3d5a8ab971cc021b750876e0f23f47
https://doi.org/10.1002/mus.21200

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Type I interferon–inducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis

Autor: Ronan J. Walsh, Jack L. Pinkus, Steven A. Greenberg, Bahija Jallal, Alan H. Beggs, Yihong Yao, Sek Won Kong, Peter A. Kiener, Anthony A. Amato

Publikováno v: Arthritis & Rheumatism. 56:3784-3792

Objective To apply gene expression profiling to the study of peripheral blood mononuclear cells from patients with inflammatory myopathies, in order to provide insight into disease pathogenesis and identify potential biomarkers associated with diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1bea15507b5318c5e85e80544538a7
https://doi.org/10.1002/art.22928

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Molecular diagnosis of inheritable neuromuscular disorders. Part II: Application of genetic testing in neuromuscular disease

Autor: Ronan J. Walsh, Steven A. Greenberg

Publikováno v: Muscle & Nerve. 31:431-451

Molecular genetic advances have led to refinements in the classification of inherited neuromuscular disease, and to methods of molecular testing useful for diagnosis and management of selected patients. Testing should be performed as targeted studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c005628f6b824b4bdffeecc6a37f87
https://doi.org/10.1002/mus.20279

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Molecular diagnosis of inheritable neuromuscular disorders. Part I: Genetic determinants of inherited disease and their laboratory detection

Autor: Steven A. Greenberg, Ronan J. Walsh

Publikováno v: Muscle & Nerve. 31:418-430

Understanding of the genetic basis of inheritable neuromuscular disorders has grown rapidly over the last decade, resulting in improved classification and understanding of their pathogenesis. A consequence of these advances has been the development o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ea51eef8e578154aeb018c32332586
https://doi.org/10.1002/mus.20278

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Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis

Autor: Steven A. Greenberg, Philip Brohawn, Yihong Yao, Bahija Jallal, Christopher Morehouse, Ronan J. Walsh, Peter A. Kiener, Anthony A. Amato, Wei Zhu, Mohammad Salajegheh, S Won Kong, Brandon W. Higgs, Barbara White

Publikováno v: Genes and immunity. 13(3)

The objective of this study was to evaluate the relationship between blood mRNA, disease activity and treatment effects in a longitudinal study of patients with dermatomyositis (DM) or polymyositis (PM). In all, 24 patients with DM or PM were followe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce73a607840b4fc81f2fd3d13336cd52
https://pubmed.ncbi.nlm.nih.gov/21881594

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