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Akademický článek

Flavaglines alleviate doxorubicin cardiotoxicity: implication of Hsp27.

Autor: Yohann Bernard, Nigel Ribeiro, Frédéric Thuaud, Gülen Türkeri, Ronan Dirr, Mounia Boulberdaa, Canan G Nebigil, Laurent Désaubry

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25302 (2011)

BackgroundDespite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that fl

Externí odkaz: https://doaj.org/article/97ec74df58f24b0f91c10728b83b956b

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Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes

Autor: Laurent Désaubry, Cyril Anthaume, Ronan Dirr

Publikováno v: Tetrahedron Letters. 49:4588-4590

An efficient approach to unsymmetrical halogenated resorcinol diethers has been developed. This synthesis consists of two subsequent nucleophilic aromatic substitutions (S N Ar) of unsymmetrical difluoroarenes by alkoxides. The novelty of this approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a26e42be7e84b480d93a038bdfcc7db
https://doi.org/10.1016/j.tetlet.2008.05.091

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Flavaglines alleviate doxorubicin cardiotoxicity: implication of Hsp27

Autor: Ronan Dirr, Laurent Désaubry, Yohann Bernard, Nigel Ribeiro, Frédéric Thuaud, Canan G. Nebigil, Mounia Boulberdaa, Gulen Turkeri

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25302 (2011)
PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (10), pp.e25302. ⟨10.1371/journal.pone.0025302⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530936a1d90ab5140d19f9d31ab4d9a3
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22065986/pdf/?tool=EBI

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Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12

Autor: Yohann Bernard, Laurent Désaubry, Canan G. Nebigil, Ronan Dirr, Catherine Tomasetto, Frédéric Thuaud, Nahum Sonenberg, Aurélie Baguet, Geneviève Aubert, Gulen Turkeri, Yuri V. Svitkin, Thierry Cresteil

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (16), pp.5176-5187. ⟨10.1021/jm900365v⟩

Flavaglines constitute a family of natural anticancer compounds. We present here 3 (FL3), the first synthetic flavagline that inhibits cell proliferation and viability (IC(50) approximately 1 nM) at lower doses than did the parent compound, racemic r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0c0ad6bf0d644a505fefe2ccb42cbb
https://hal.archives-ouvertes.fr/hal-00467437

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ChemInform Abstract: Regioselectivity of Fluorine Substitution by Alkoxides on Unsymmetrical Difluoroarenes

Autor: Ronan Dirr, Laurent Désaubry, Cyril Anthaume

Publikováno v: ChemInform. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dda59fa5ce939d523c01fda1d894afea
https://doi.org/10.1002/chin.200844063

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Corrigendum to 'Regioselectivity of fluorine substitution by alkoxides on unsymmetrical difluoroarenes' [Tetrahedron Lett. 49 (2008) 4588]

Autor: Laurent Désaubry, Ronan Dirr, Cyril Antheaume

Publikováno v: Tetrahedron Letters. 49:7083

0040-4039/$ - see front matter 2008 Elsevier Ltd. All rights reserved.doi:10.1016/j.tetlet.2008.09.121DOI of original article: 10.1016/j.tetlet.2008.05.091* Corresponding author. Tel.: +33 90 244 141; fax: +33 390 244 310.E-mail address: desaubry@chi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e03ef63c7e29e057e795d3e76ce91c6
https://doi.org/10.1016/j.tetlet.2008.09.121

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Akademický článek

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12.

Autor: Frédéric Thuaud, Yohann Bernard, Gülen Türkeri, Ronan Dirr, Geneviève Aubert, Thierry Cresteil, Aurélie Baguet, Catherine Tomasetto, Yuri Svitkin, Nahum Sonenberg, Canan G. Nebigil, Laurent Désaubry

Publikováno v: Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 16, p5176-5187, 12p

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