Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ronan Broderick"'
Autor:
Ronan Broderick, Veronica Cherdyntseva, Jadwiga Nieminuszczy, Eleni Dragona, Maria Kyriakaki, Theodora Evmorfopoulou, Sarantis Gagos, Wojciech Niedzwiedz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Telomerase-independent cancer proliferation via the alternative lengthening of telomeres (ALT) relies upon two distinct, largely uncharacterized, break-induced-replication (BIR) processes. How cancer cells initiate and regulate these termina
Externí odkaz:
https://doaj.org/article/4c85c2750cba42c18c6c9d363e697013
Autor:
Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA s
Externí odkaz:
https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805
Autor:
Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 8: Article number: 15983 (2017); Published: 17 July 2017; Updated: 26 October 2017 In this Article, there are errors in the labelling of the y axis in Fig. 1a and Supplementary Fig. 1b. The labels ‘20’, ‘40’, ‘60’,
Externí odkaz:
https://doaj.org/article/34574dfb75be41acbdd43dc3fd63e567
Autor:
Ronan Broderick, Sivaramakrishnan Ramadurai, Katalin Tóth, Denisio M Togashi, Alan G Ryder, Jörg Langowski, Heinz Peter Nasheuer
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35537 (2012)
Eukaryotic DNA replication is a dynamic process requiring the co-operation of specific replication proteins. We measured the mobility of eGFP-Cdc45 by Fluorescence Correlation Spectroscopy (FCS) in vivo in asynchronous cells and in cells synchronized
Externí odkaz:
https://doaj.org/article/047d8be4478e45f3a39ad306bcde3cf1
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Supplementary Table from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7bde9d3ff1abb9ef60efb2134cb7ae
https://doi.org/10.1158/0008-5472.22433010
https://doi.org/10.1158/0008-5472.22433010
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Supplementary Data from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1587dcc4a0be2c2d50162b142e37df4
https://doi.org/10.1158/0008-5472.22433013
https://doi.org/10.1158/0008-5472.22433013
Autor:
Irene Y. Chong, Christopher J. Lord, Wojciech Niedzwiedz, Syed Haider, Andres Cervantes, Johann de Bono, Stephen J. Pettitt, Jyoti Choudhary, Theodoros Roumeliotis, Ana Ferreira, Ruth Riisnaes, Bora Gurel, Frank T. Zenke, Astrid Zimmermann, Rachel Brough, Ronan Broderick, Malgorzata Dylewska, Feifei Song, John Alexander, Jadwiga Nieminuszczy, Dragomir B. Krastev, Lauren I. Aronson, Marta J. Llorca-Cardenosa
Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors (ATRi), have been proposed as novel targeted agents in gastric cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e563c09a484cf966f330a341b09c73e
https://doi.org/10.1158/0008-5472.c.6514290.v1
https://doi.org/10.1158/0008-5472.c.6514290.v1
Autor:
Jadwiga Nieminuszczy, Peter R Martin, Ronan Broderick, Joanna Krwawicz, Alexandra Kanellou, Camelia Mocanu, Vicky Bousgouni, Charlotte Smith, Kuo-Kuang Wen, Beth L Woodward, Chris Bakal, Fiona Shackley, Andrés Aguilera, Grant S Stewart, Yatin M Vyas, Wojciech Niedzwiedz
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication forks. These responses rely on the formation of Replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5531b5742effadd75fbaf524f41866e4
https://doi.org/10.1101/2023.01.12.523639
https://doi.org/10.1101/2023.01.12.523639
Autor:
Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Publikováno v:
CANCER RESEARCH
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
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Gastric cancer represents the third leading cause of global cancer mortality and an area of unmet clinical need. Drugs that target the DNA damage response, including ATR inhibitors (ATRi), have been proposed as novel targeted agents in gastric cancer