Ghrelin uses the GHS-R1a/Gi/cAMP pathway and induces differentiation only in mature osteoblasts. This ghrelin pathway is impaired in AIS patients

Autor: Jérôme Sales de Gauzy, Nicolas Beton, Aurélie Batut, Frank Accabled, Isabelle Gennero, Jean Pierre Salles, Françoise Conte Auriol, Ronan Barre, Sara Laurencin, Maithé Tauber, Sanaa Eddiry

Publikováno v: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, 2020, 24, pp.100782-. ⟨10.1016/j.bbrep.2020.100782⟩
Biochemistry and Biophysics Reports, Vol 24, Iss, Pp 100782-(2020)

We have examined the Acylated Ghrelin (AG)/Gi pathway in different human osteoblastic cell lines. We have found that: 1) AG induces differentiation/mineralization only in mature osteoblasts; 2) the expression of GHS-R1a increases up to the mature cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72d04e8f69ee3f16ee60115d7527df0
http://europepmc.org/articles/PMC7494670

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein

Autor: Ronan Barre, Clotilde Cariven, Aline Awad, Jean Pierre Salles, Christophe Erneux, Didier Samuel, Mickaël Marin, Sokhavuth Sar, Ama Gassama-Diagne

Publikováno v: Molecular Biology of the Cell
Molecular biology of the cell, 24 (14

The main targets of hepatitis C virus (HCV) are hepatocytes, the highly polarized cells of the liver, and all the steps of its life cycle are tightly dependent on host lipid metabolism. The interplay between polarity and lipid metabolism in HCV infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b71574cb899a7230a79243806c4e63
https://pubmed.ncbi.nlm.nih.gov/23699395