Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ronan, LE Bot"'
Publikováno v:
ACS Omega, Vol 9, Iss 41, Pp 42433-42447 (2024)
Externí odkaz:
https://doaj.org/article/8da51c7c4e704306ac406e0602d21e6a
Autor:
Emmanuelle David, Pierre Boyé, Maxim Egorov, Kévyn Geeraert, Jean-Yves Goujon, Laurent Marescaux, François Serres, Sébastien Cagnol, Virginie Coste, Dominique Tierny, Ronan Le Bot, Franck Floch, Quentin Pascal
Publikováno v:
Oncotarget
Boyé, P, David, E, Serres, F, Pascal, Q, Floch, F, Geeraert, K, Coste, V, Marescaux, L, Cagnol, S, Goujon, J-Y, Egorov, M, Le Bot, R & Tierny, D 2020, ' Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma ', Oncotarget, vol. 11, no. 46, pp. 4281-4292 . https://doi.org/10.18632/oncotarget.27801
Boyé, P, David, E, Serres, F, Pascal, Q, Floch, F, Geeraert, K, Coste, V, Marescaux, L, Cagnol, S, Goujon, J-Y, Egorov, M, Le Bot, R & Tierny, D 2020, ' Phase I dose escalation study of 12b80 (hydroxybisphosphonate linked doxorubicin) in naturally occurring osteosarcoma ', Oncotarget, vol. 11, no. 46, pp. 4281-4292 . https://doi.org/10.18632/oncotarget.27801
PURPOSE: 12b80 combines doxorubicin bound to a bone targeting hydroxybisphosphonate vector using a pH-sensitive linker, designed to specifically trigger doxorubicin release in an acidic bone tumor microenvironment. This phase I study aimed to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132fd476b57b5582d4e05d13256f7d5a
http://europepmc.org/articles/PMC7679038
http://europepmc.org/articles/PMC7679038
Autor:
Marie Sicard, Françoise Rédini, Emmanuelle David, Maxim Egorov, Samuel Pairel, Jean-Yves Goujon, Laëtitia Morandeau, Christelle Moal, Charlène Benesteau, Dominique Heymann, Julien Taurelle, François Gouin, Sébastien Cagnol, Ronan Le Bot
Publikováno v:
Bioconjugate Chemistry. 30:1665-1676
To reply to as yet unmet medical needs to treat osteosarcoma, a form of primary bone cancer, we conceived the 12b80 compound by covalently conjugating antineoplastic compound doxorubicin to a bone targeting hydroxybisphosphonate vector and turned it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7629eee0abf9ac2671439b64eb1889c
https://doi.org/10.1021/acs.bioconjchem.9b00210
https://doi.org/10.1021/acs.bioconjchem.9b00210
Autor:
Alexandrine Luseau, Emmanuelle David, David Monderer, Ronan Le Bot, Marie-Françoise Heymann, François Gouin, Marine Biger, Françoise Rédini, Laurence Lode, Marc G. Denis, Dominique Heymann, Stéphanie Ponsolle, Amelie Bellec, Sylvain Bercegeay, Frédéric Blanchard, Soraya Saiagh, Philippe Piloquet
Publikováno v:
Laboratory Investigation. 93:1100-1114
Chondrosarcomas are cartilage-forming, poorly vascularized tumors. They represent the second malignant primary bone tumor of adults after osteosarcoma, but in contrast to osteosarcoma they are resistant to chemotherapy and radiotherapy, surgical exci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b34a56314271062804f4bda96364e4
https://doi.org/10.1038/labinvest.2013.101
https://doi.org/10.1038/labinvest.2013.101
Autor:
Arnaud Bondon, Maxim Egorov, Ronan Le Bot, Yves François Pouchus, Marieke Vansteelandt, Fabien Petit, Olivier Grovel, Loïc Toupet, Fabrice Monteau, Bruno Le Bizec, Elodie Blanchet, Olivier P. Thomas
Publikováno v:
Journal of Natural Products
Journal of Natural Products, American Chemical Society, 2013, 76 (2), pp.297-301. ⟨10.1021/np3007364⟩
Journal of Natural Products, 2013, 76 (2), pp.297-301. ⟨10.1021/np3007364⟩
Journal of Natural Products, American Chemical Society, 2013, 76 (2), pp.297-301. ⟨10.1021/np3007364⟩
Journal of Natural Products, 2013, 76 (2), pp.297-301. ⟨10.1021/np3007364⟩
International audience; A new chlorinated sesquiterpenoid analogue of fumagillin, ligerin (1), was isolated from a marine-derived strain of Penicillium, belonging to the subgenus Penicillium, along with the known compounds penicillic acid (2), orcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8c9caec950aa1b5717ea6d1d262c40
https://doi.org/10.1021/np3007364
https://doi.org/10.1021/np3007364
Publikováno v:
Hand Surgery and Rehabilitation. 36:431-432
Les chambres de regeneration nerveuse sont utilisees pour diminuer la morbidite des sites donneurs des greffes. Nous proposons un biomateriau securise issu d’une artere ombilicale retournee de placenta humain contenant de la gelee de Wharton riche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f79cba4c4670183af9394300339781b
https://doi.org/10.1016/j.hansur.2017.10.017
https://doi.org/10.1016/j.hansur.2017.10.017
Autor:
Stéphanie Ponsolle, Ronan Le Bot, Anne Riet, Carl D. Richards, Pierre J. Guihard, Séverine Battaglia, Frédéric Blanchard, Françoise Rédini, Céline Charrier, Dominique Heymann, François Gouin, Bénédicte Brounais, Emmanuelle David
Publikováno v:
International Journal of Cancer. 128:1822-1835
The cytokine Oncostatin M (OSM) is cytostatic, pro-apoptotic and induces differentiation of osteosarcoma cells into osteocytes, suggesting new adjuvant treatment for these bone-forming sarcomas. However, OSM systemic over-expression could lead to adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6f3a06a96db7f413c9f57285eabb05
https://doi.org/10.1002/ijc.25776
https://doi.org/10.1002/ijc.25776
Autor:
Marieke Vansteelandt, Olivier Grovel, Elodie Blanchet, Maxim Egorov, Yves François Pouchus, Yann Guitton, Ronan Le Bot
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 79, pp.244-250. ⟨10.1016/j.ejmech.2014.04.012⟩
European Journal of Medicinal Chemistry, 2014, 79, pp.244-250. ⟨10.1016/j.ejmech.2014.04.012⟩
European Journal of Medicinal Chemistry, Elsevier, 2014, 79, pp.244-250. ⟨10.1016/j.ejmech.2014.04.012⟩
European Journal of Medicinal Chemistry, 2014, 79, pp.244-250. ⟨10.1016/j.ejmech.2014.04.012⟩
International audience; Ligerin is a natural chlorinated merosesquiterpenoid related to fumagillin exhibiting a selective antiproliferative activity against osteosarcoma cell lines and an in vivo antitumor activity in a murine model. Semisynthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba82f9ec5d05271b848d4997d4fdbc
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03279261
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03279261
Autor:
Florence, Daubine, Ronan, LE Bot, Marcela, Márquez, Sten, Nilsson, Torbjörn, Schröder, Anders R, Holmberg
Publikováno v:
Anticancer research. 31(12)
To investigate the in vivo efficacy of a novel polybisphosphonate (ODX) in the treatment of bone metastasis from prostate cancer.A rat prostatic carcinoma model was used. Forty-two rats (21 control, 21 treatment) had induction of bone lesions through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d04fccdc4520c02f1611fb2512b693e9
https://pubmed.ncbi.nlm.nih.gov/22199272
https://pubmed.ncbi.nlm.nih.gov/22199272