Elucidating molecular mechanisms of actinobacterial polyketide alkaloid biosynthesis

Autor: Ronan, Jade L.

Coelimycin P1 is a yellow-pigmented alkaloid with a unique 1,5-oxathiocane ring, produced by Streptomyces coelicolor M145. Recently, it was demonstrated that a type I modular polyketide synthase (PKS) with a C-terminal thioester reductase (TR) domain

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731420

Supplementary Material: Desferrioxamine biosynthesis: Diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC

Autor: Ronan, Jade L., Kadi, Nadia, McMahon, Stephen A., Naismith, James H., Alkhalaf, Lona M., Challis, Gregory L.

Experimental procedures and supporting data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f453bb20cc8817a3ae1eb0b9b35c591

Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

Autor: Ronan JL; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK., Kadi N; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK., McMahon SA; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK., Naismith JH; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK., Alkhalaf LM; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK., Challis GL; Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK g.l.challis@warwick.ac.uk.

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2018 Jun 05; Vol. 373 (1748).