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Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.

Autor: Yarbro JM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; These authors contributed equally., Han X; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; These authors contributed equally., Dasgupta A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Current address: Department of Computer Science and Engineering, SRM University AP, Andhra Pradesh 522240, India.; These authors contributed equally., Yang K; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; These authors contributed equally., Liu D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Shrestha HK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zaman M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yu K; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lee DG; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vanderwall D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Niu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Sun H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Xie B; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen PC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Jiao Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zhang X; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Fu Y; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Li Y; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang X; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA., Poudel S; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vagnerova B; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA., He Q; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA., Tang A; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA., Ronaldson PT; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA., Chang R; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA., Yu G; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Liu Y; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.; Yale Cancer Research Institute, Yale University School of Medicine, West Haven, CT, 06516, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.

Candesartan restores blood-brain barrier dysfunction, mitigates aberrant gene expression, and extends lifespan in a knockin mouse model of epileptogenesis.

Autor: Hammer MF; BIO5 Institute, University of Arizona, Tucson, AZ, U.S.A.; Department of Neurology, University of Arizona, Tucson, AZ, U.S.A., Bahramnejad E; BIO5 Institute, University of Arizona, Tucson, AZ, U.S.A.; Department of Pharmacology, University of Arizona, Tucson, AZ, U.S.A., Watkins JC; Department of Mathematics, University of Arizona, Tucson, AZ, U.S.A., Ronaldson PT; Department of Pharmacology, University of Arizona, Tucson, AZ, U.S.A.

Publikováno v: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2024 Sep 04; Vol. 138 (17), pp. 1089-1110.