Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ronalds Zemribo"'
Autor:
Gints Smits, Ronalds Zemribo
Publikováno v:
Organic & Biomolecular Chemistry. 18:4566-4568
A synthetic approach towards the core of a structurally unique cytotoxic indole alkaloid eleganine A has been accomplished for the first time. The synthesis features a stereoselective Ireland-Claisen rearrangement as the key step, enabling the instal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae93ee96a64a3d32bcde254802488ef
https://doi.org/10.1039/d0ob00939c
https://doi.org/10.1039/d0ob00939c
Publikováno v:
Tetrahedron Letters. 58:2426-2428
The first total synthesis of usabamycins A and C from inexpensive and readily available amino acids – homoalanine and glycine and featuring a stereoselective Ireland-Claisen rearrangement as well as a novel 7-membered ring formation reaction is des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e567f9ed9f7f18b2ddb38ed2a138e9
https://doi.org/10.1016/j.tetlet.2017.05.020
https://doi.org/10.1016/j.tetlet.2017.05.020
Publikováno v:
Tetrahedron Letters. 56:5882-5885
Quaternary gramines were found to be a suitable source of the 3-methylindole fragment for diastereoselective alkylation. The best yields and stereoselectivity were obtained for the alkylation of a chiral William’s morpholinone enolate. Based on thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d50ac5c32a29fcd64aff7a85db9f6796
https://doi.org/10.1016/j.tetlet.2015.09.017
https://doi.org/10.1016/j.tetlet.2015.09.017
Publikováno v:
European Journal of Organic Chemistry. 2015:6701-6709
The Ireland–Claisen rearrangement of 6-methylene-1,4-oxazepan-2-one-derived boron enolates leads to stereochemically defined, synthetically useful 4-(E)-ethylidene prolines. Detailed computational and experimental studies explain the stereochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5926b9588360f40f1f2761ef774f87
https://doi.org/10.1002/ejoc.201500918
https://doi.org/10.1002/ejoc.201500918
Autor:
Ronalds Zemribo, Gints Smits
Publikováno v:
Synlett. 26:2272-2276
A one-step synthesis of pyrrolo[1,4]benzodiazepine dilactams has been developed. The high yielding method involves direct coupling of unprotected anthranilic acids with proline esters. This transformation was successfully applied in the first total s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf6161a58a11f62bbff8829c66f7409
https://doi.org/10.1055/s-0034-1378877
https://doi.org/10.1055/s-0034-1378877
Autor:
Gints Smits, Ronalds Zemribo
Publikováno v:
European Journal of Organic Chemistry. 2015:3152-3156
A stereoselective total synthesis of one diastereomer of 8-deoxypumiliotoxin 193H is described. The concise total synthesis features the use of readily available natural amino acids as the starting materials and the Ireland–Claisen rearrangement as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062b41c8e084ac2dc94072d9dd99c35d
https://doi.org/10.1002/ejoc.201500063
https://doi.org/10.1002/ejoc.201500063
Autor:
Ulrich Abel, Patrick Plitt, Kai-Uwe Klein, Mirko Hechenberger, Udo Meyer, Sander G. A. van Assema, Holger Kubas, Harm W. Spexgoor, Ronalds Zemribo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6370-6376
The metabotropic glutamate receptor subtype 5 has evolved into a promising target for the treatment of various diseases of the central nervous system, such as Fragile X and l -DOPA induced dyskinesia. One of the most advanced clinical compound is Nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6397fe4ac3e1a75ee548e5012845b5
https://doi.org/10.1016/j.bmcl.2013.09.059
https://doi.org/10.1016/j.bmcl.2013.09.059
Publikováno v:
Tetrahedron Letters. 56:4767-4769
The first total syntheses of limazepines C and D were accomplished from inexpensive and readily available starting materials using an iron pentacarbonyl promoted allylamide–enamide double bond migration as a key step. The obtained limazepine C was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090f62a617f5c8960d911b3e39cf70b1
https://doi.org/10.1016/j.tetlet.2015.06.051
https://doi.org/10.1016/j.tetlet.2015.06.051
Autor:
Ronalds Zemribo, Gints Smits
Publikováno v:
Organic Letters. 15:4406-4409
Stereoselective total syntheses of Limazepine E and Barmumycin, potent, naturally occurring antitumor agents, are described. The total syntheses control the olefin geometry via a highly selective chelation-controlled Ireland-Claisen rearrangement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773b08cc1f7585f3b028fc90894ab04b
https://doi.org/10.1021/ol4019453
https://doi.org/10.1021/ol4019453
Publikováno v:
ChemInform. 47
Quaternary gramines were found to be a suitable source of the 3-methylindole fragment for diastereoselective alkylation. The best yields and stereoselectivity were obtained for the alkylation of a chiral William’s morpholinone enolate. Based on thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32abc7af61f739b85b5ac4c5e35afef
https://doi.org/10.1002/chin.201615118
https://doi.org/10.1002/chin.201615118