Výsledky vyhledávání - "Ronaldo F. Hashimoto"

Akademický článek

A dynamic Boolean network reveals that the BMI1 and MALAT1 axis is associated with drug resistance by limiting miR-145-5p in non-small cell lung cancer

Autor: Shantanu Gupta, Daner A. Silveira, Gabriel P.S. Piedade, Miguel P. Ostrowski, José Carlos M. Mombach, Ronaldo F. Hashimoto

Publikováno v: Non-coding RNA Research, Vol 9, Iss 1, Pp 185-193 (2024)

Patients with non-small cell lung cancer (NSCLC) are often treated with chemotherapy. Poor clinical response and the onset of chemoresistance limit the anti-tumor benefits of drugs such as cisplatin. According to recent research, metastasis-associate

Externí odkaz: https://doaj.org/article/24586555d16442aa80f64832dd5278eb

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Akademický článek

The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: A Boolean model of cell death

Autor: Shantanu Gupta, Daner A. Silveira, José Carlos M. Mombach, Ronaldo F. Hashimoto

Publikováno v: Non-coding RNA Research, Vol 8, Iss 4, Pp 605-614 (2023)

Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical cancer. Although it was found that the microRNA-16-5p (miR-16), which is kno

Externí odkaz: https://doaj.org/article/699461c02e434c4480b5fcbd518adb39

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Akademický článek

Network analysis reveals that the tumor suppressor lncRNA GAS5 acts as a double-edged sword in response to DNA damage in gastric cancer

Autor: Shantanu Gupta, Pritam Kumar Panda, Wei Luo, Ronaldo F. Hashimoto, Rajeev Ahuja

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract The lncRNA GAS5 acts as a tumor suppressor and is downregulated in gastric cancer (GC). In contrast, E2F1, an important transcription factor and tumor promoter, directly inhibits miR-34c expression in GC cell lines. Furthermore, in the corre

Externí odkaz: https://doaj.org/article/d5a43429976b4c7da90cad35f700f803

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Akademický článek

Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

Autor: Shantanu Gupta, Pritam Kumar Panda, Ronaldo F. Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr. Verma, Yogendra Kumar Mishra, Rajeev Ahuja

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been shown to influence autophagy in cervical cancer. However, the function of mi

Externí odkaz: https://doaj.org/article/e929325d5a1f40f7aef68c332f6fea5b

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Akademický článek

Quadra-Stable Dynamics of p53 and PTEN in the DNA Damage Response

Autor: Shantanu Gupta, Pritam Kumar Panda, Daner A. Silveira, Rajeev Ahuja, Ronaldo F. Hashimoto

Publikováno v: Cells, Vol 12, Iss 7, p 1085 (2023)

Cell fate determination is a complex process that is frequently described as cells traveling on rugged pathways, beginning with DNA damage response (DDR). Tumor protein p53 (p53) and phosphatase and tensin homolog (PTEN) are two critical players in t

Externí odkaz: https://doaj.org/article/4cda6be44015427f8f0b2077cf8d2863

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Akademický článek

A Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells

Autor: Shantanu Gupta, Daner A. Silveira, Ronaldo F. Hashimoto, Jose Carlos M. Mombach

Publikováno v: Biology, Vol 11, Iss 4, p 480 (2022)

The long non-coding RNA X inactivate-specific transcript (lncRNA XIST) has been verified as an oncogenic gene in non-small cell lung cancer (NSCLC) whose regulatory role is largely unknown. The important tumor suppressors, microRNAs: miR-449a and miR

Externí odkaz: https://doaj.org/article/3aa5a2f4822b4df383a002b659774dce

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Akademický článek

Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer

Autor: Shantanu Gupta, Ronaldo F. Hashimoto

Publikováno v: Biomolecules, Vol 12, Iss 3, p 420 (2022)

Long non-coding RNA (lncRNA) such as ANRIL and UFC1 have been verified as oncogenic genes in non-small cell lung cancer (NSCLC). It is well known that the tumor suppressor microRNA-34a (miR-34a) is downregulated in NSCLC. Furthermore, miR-34a induces

Externí odkaz: https://doaj.org/article/f09da447848a4047a5ed4910f90f4ead

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Interactive image manipulation using morphological trees and spline-based skeletons

Autor: Jieying Wang, Dennis J. Silva, Jiří Kosinka, Alexandru Telea, Ronaldo F. Hashimoto, Jos B.T.M. Roerdink

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Computers & Graphics, 108, 61-73. PERGAMON-ELSEVIER SCIENCE LTD

The ability to edit an image using intuitive commands and primitives is a desired feature for any image editing software. In this paper, we combine recent results in medial axes with the well-established morphological tree representations to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc258772b1222311a6283d9997e862e
https://hdl.handle.net/11370/a922861b-49f9-4f03-b110-12d663aa3a24

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