Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ronald W. McClard"'
Publikováno v:
Biochemistry. 46:14075-14086
Orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) catalyzes the Mg2+-dependent condensation of orotic acid (OA) with PRPP (5-alpha-d-phosphorylribose 1-diphosphate) to yield diphosphate (PPi) and the nucleotide OMP (orotidine 5'-monophosphate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727c736cf7403e9ff4ba7869484b9c9e
https://doi.org/10.1021/bi701023z
https://doi.org/10.1021/bi701023z
Autor:
David E. Timm, Ronald W. McClard, Thomas D. Hurley, Markus Grompe, Raynard L. Bateman, L.-J. Baker, John F. Witte, Justin Ashworth, Pullooru Bhanumoorthy
Publikováno v:
Biochemical Journal. 402:251-260
FAH (fumarylacetoacetate hydrolase) catalyses the final step of tyrosine catabolism to produce fumarate and acetoacetate. HT1 (hereditary tyrosinaemia type 1) results from deficiency of this enzyme. Previously, we prepared a partial mimic of the puta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b37ffbe71334da191b79933cdbf3a7
https://doi.org/10.1042/bj20060961
https://doi.org/10.1042/bj20060961
Autor:
Ronald W. McClard, John F. Witte
Publikováno v:
Bioorganic Chemistry. 24:29-38
d - ribo -2,5-anhydro-1,3-dideoxy-1-(((dihydroxyphosphinyl)oxy)hydroxyphosphinyl)-6-phosphorylhexitol, compound 4, along with 25% of its d -arabino epimer, was synthesized in 10 steps from 2-deoxyribonolactone. Compound 4 represents the 2-deoxy analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc08eb324fd857d09570bec4257cadab
https://doi.org/10.1006/bioo.1996.0004
https://doi.org/10.1006/bioo.1996.0004
Autor:
Markus Grompe, Gregory N. Clarke, Carl Pelz, Ronald W. McClard, Amy E. Hanlon Newell, Karsten Wursthorn, Nicole K. Paulk, Milton J. Finegold, John F. Witte, Susan B. Olson, Cary O. Harding, Annelise Haft, Raymond L Bateman
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 20(10)
Genetic fumarylacetoacetate hydrolase (Fah) deficiency is unique in that healthy gene-corrected hepatocytes have a strong growth advantage and can repopulate the diseased liver. Unfortunately, similar positive selection of gene-corrected cells is abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7f0a52955ad8db956a8e44afbcc72a
https://pubmed.ncbi.nlm.nih.gov/22871666
https://pubmed.ncbi.nlm.nih.gov/22871666
Publikováno v:
Journal of Thermal Biology. 19:111-122
1. 1.|In fatty acid supplemented E. coli auxotrophs the degree of saturation in acyl chains 18 carbons long did not influence the translocation of protein to the outer membrane under hyperthermal stress. However, in cells grown in medium supplemented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e227bc1cc07160e6aef16aa43fa598
https://doi.org/10.1016/0306-4565(94)90058-2
https://doi.org/10.1016/0306-4565(94)90058-2
Publikováno v:
ChemInform. 22
A very mild method for the preparation of synthetically useful phosphonic dichlorides has been developed and its application toward the synthesis of 2-alkyl-2-oxo-1, 3, 2-dioxophosphorinanes and 1, 3-dimethyl-2-alkyl-2-oxo-1, 3, 2-diazaphospholidines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e073c654279ad16d2c5ff40f8f37d64
https://doi.org/10.1002/chin.199128194
https://doi.org/10.1002/chin.199128194
Autor:
John F. Witte, Ronald W. McClard
Publikováno v:
ChemInform. 23
The dihydropyrrole 2 was synthesized in four steps from a protected lyxose derivative. This compound exists as one component of a complex equilibrium that may also contain the hydrated forms, 7 , as well as a dimeric form. The mixture comprises a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f2c0ab30cda74a4692eb19bcc6a6c7a
https://doi.org/10.1002/chin.199218182
https://doi.org/10.1002/chin.199218182
Autor:
Ronald W. McClard, John F. Witte
Publikováno v:
Tetrahedron Letters. 32:3927-3930
The dihydropyrrole 2 was synthesized in four steps from a protected lyxose derivative. This compound exists as one component of a complex equilibrium that may also contain the hydrated forms, 7 , as well as a dimeric form. The mixture comprises a pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0d958e2c785f9ceb26ed5466e311d6
https://doi.org/10.1016/0040-4039(91)80591-s
https://doi.org/10.1016/0040-4039(91)80591-s
Autor:
John F. Witte, Ronald W. McClard
Publikováno v:
Bioorganic Chemistry. 18:165-178
Phosphonate analogs of 5-phosphorylribose 1-α-diphosphate (PRPP), in which the anomeric oxygen has been replaced by carbon ( C -glycoside analogs), have been prepared in multistep syntheses. The exact “ribosyl” analog could not be elaborated fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478005da412bb1f7f02838eab7d198b0
https://doi.org/10.1016/0045-2068(90)90039-8
https://doi.org/10.1016/0045-2068(90)90039-8
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(23)
A mimic of the putative transition-state intermediate has been synthesized and found to be a very slow-onset inhibitor of yeast orotate phosphoribosyltransferase. The mechanism of inhibition may involve a rate-determining isomerization of the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6216e72da59a8cc9eac6a9c44050976
https://pubmed.ncbi.nlm.nih.gov/16979338
https://pubmed.ncbi.nlm.nih.gov/16979338